Journal ArticleDOI
One-pot strategy for thiazole tethered 7-ethoxy quinoline hybrids: Synthesis and potential antimicrobial agents as dihydrofolate reductase (DHFR) inhibitors with molecular docking study
Yousry A. Ammar,Sondos M.A. Abd El-Hafez,Sadia A. Hessein,Abeer M. Ali,Ahmed A. Askar,Ahmed Ragab +5 more
Reads0
Chats0
TLDR
Molecular docking study against DHFR enzyme (1DLS) was carried out, and the active derivatives bind to some the nearly the same amino acid residues as MTX that support the hypothesis that quinoline antibiotic class can be solved by discovering new targets and inhibitors.About:
This article is published in Journal of Molecular Structure.The article was published on 2021-10-15. It has received 29 citations till now. The article focuses on the topics: Dihydrofolate reductase & Quinoline.read more
Citations
More filters
Journal ArticleDOI
Hydrazonoyl bromide precursors as DHFR inhibitors for the synthesis of bis-thiazolyl pyrazole derivatives; antimicrobial activities, antibiofilm, and drug combination studies against MRSA.
TL;DR: In this article, a series of new bis-thiazolyl-pyrazole derivatives 3, 4a-c, 5a, b, and 6a -c was synthesized by reacting bis hydrazonoyl bromide with several active methylene reagents in a one-pot reaction.
Journal ArticleDOI
Design, synthesis of new magenta dyestuffs based on thiazole azomethine disperse reactive dyes with antibacterial potential on both dyes and gamma-irradiated dyed fabric
TL;DR: In this paper, a series of new magenta azomethine reactive disperse dyes were synthesized and applied into polyester/cotton blend fabrics, and various spectroscopic and analytical techniques characterized all the synthesized dyes.
Journal ArticleDOI
Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study
TL;DR: In this paper , a series of new thiazolo-indolin-2-one derivatives were synthesized based on acid and base catalyzed condensation or reaction of thiosemicarbazone 8 with different electrophilic reagents.
Journal ArticleDOI
One-Pot Synthesis and Molecular Modeling Studies of New Bioactive Spiro-Oxindoles Based on Uracil Derivatives as SARS-CoV-2 Inhibitors Targeting RNA Polymerase and Spike Glycoprotein
Samar A. El-Kalyoubi,Ahmed Ragab,Ola A. Abu Ali,Yousry A. Ammar,Mohamed G. Seadawy,Aya Ahmed,Eman A. Fayed +6 more
TL;DR: This study aims to design a simple and efficient cyclo-condensation reaction of 6-aminouracil derivatives 2a–e and isatin derivatives 1a–c to synthesize spiro-oxindoles 3a–d, 4 a–e, and 5a-e to synthesise spiro’s most active hybrids.
Journal ArticleDOI
Design, synthesis of new novel quinoxalin-2(1H)-one derivatives incorporating hydrazone, hydrazine, and pyrazole moieties as antimicrobial potential with in-silico ADME and molecular docking simulation
Ahmed Ragab,Doaa M. Elsisi,Ola A. Abu Ali,Moustafa S. Abusaif,Ahmed A. Askar,Awatef A. Farag,Yousry A. Ammar +6 more
TL;DR: A series of 6-(morpholinosulfonyl)quinoxalin-2(1H)-one based hydrazone, hydrazine, and pyrazole moieties were designed, synthesized, and evaluated for their in vitro antimicrobial activity.
References
More filters
Journal ArticleDOI
Exploring Anti-inflammatory Potential of Thiazolidinone Derivatives of Benzenesulfonamide via Synthesis, Molecular Docking and Biological Evaluation.
Sanjay B. Bari,Sandip D. Firake +1 more
TL;DR: In this article, the synthesis and biological evaluation of thiazolidinone derivatives bearing benzenesulfonamide investigated for cyclooxygenase-2 (COX-2) inhibitory activity and in vivo anti-inflammatory activity.
Journal ArticleDOI
Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study
Sherihan El-sayed,Kamel Metwally,Abdalla El-Shanawani,Lobna M. Abdel-Aziz,Ahmed A. Elrashedy,Mahmoud E. S. Soliman,Luca Quattrini,Vito Coviello,Concettina La Motta +8 more
TL;DR: A series of quinazolinone-based rhodanine-3-acetic acids was synthesized and tested for in vitro aldose reductase inhibitory activity and structure-activity relationship studies indicated that bulky substituents at the 3-phenyl ring of the quinzolinone moiety are generally not tolerated in the active site of the enzyme.
Journal ArticleDOI
Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors.
Waad D. Alrohily,Mahmoud E. Habib,Shahenda M. El-Messery,Shahenda M. El-Messery,Abdulmalik Alqurshi,Hussein I. El-Subbagh,El-Sayed E. Habib,El-Sayed E. Habib +7 more
TL;DR: Thiazole based chalcones are studied as efficient leads for designing new future antibacterial drug candidates and ADMET calculations suggested that they could be good orally absorbed antibacterial agents while compound 38 could be an orally absorbed anticancer agent with diminished toxicity.
Journal Article
1-(4-substituted-thiazol-2-yl)hydantoins as anti-inflammatory and CNS-active agents.
Journal ArticleDOI
Enantioselective Synthesis of Substituted 3-Quinolyl Alkanols and Their Application to Asymmetric Autocatalysis
TL;DR: In this article, enantioenriched 3-quinolyl alkanols act as asymmetric autocatalysts in the addition of diisopropylzinc to the corresponding substituted quinoline-3-carbaldehydes, to afford themselves with an amplified enantiomeric excess of up to 97%.