Journal ArticleDOI
Oocyte–somatic cell interactions during follicle development in mammals
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TLDR
Elucidating the nature of oocyte-somatic cell interactions at the various stages of follicle development will have important implications for the understanding of factors regulating folliculogenesis, ovulation rate and fecundity.About:
This article is published in Animal Reproduction Science.The article was published on 2004-07-01. It has received 559 citations till now. The article focuses on the topics: Folliculogenesis & Granulosa cell.read more
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Role of cAMP modulator supplementations during oocyte in vitro maturation in domestic animals.
G. R. Leal,C. A. S. Monteiro,Joanna Maria Gonçalves Souza-Fabjan,Carlos Otávio de Paula Vasconcelos,Luiz Altamiro Garcia Nogueira,Ana Maria Reis Ferreira,R. V. Serapião +6 more
TL;DR: The aim of this review is to comprehensively evaluate and provide data related to the use of cAMP modulators during IVM and the effects on completion of meiosis and cytoplasmic reorganization, which are required for development of oocytes with the capacity to contribute to fertilization and subsequent embryonic development.
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The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
TL;DR: Taken together, Immp2l causes ovarian aging through the ROS-Wnt/β-catenin-estrogen (cyp19a1) pathway, which can be reversed by melatonin treatment, which delayed granulosa cell aging progression.
Journal ArticleDOI
Bone morphogenetic protein 15 and growth differentiation factor 9 expression in the ovary of European sea bass (Dicentrarchus labrax): Cellular localization, developmental profiles, and response to unilateral ovariectomy
TL;DR: The cellular localization, the developmental profiles, and the response to unilateral ovariectomy of protein and mRNA steady-state levels of Bmp15 and Gdf9 in the ovary of European sea bass, an important fish species for marine aquaculture industry are described.
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Heat stress induces distinct responses in porcine cumulus cells and oocytes associated with disrupted gap junction and trans-zonal projection colocalization.
TL;DR: It is indicated that HS induces distinct responses in porcine CCs and oocytes in association with disrupted GJ and TZP colocalization.
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Temporal expression of GDF-9 and BMP-15 mRNAs in canine ovarian follicles.
TL;DR: These two genes were detected in follicular cells and oocytes and were differentially expressed during the follicular development across the estrus cycle, and remained constant during the final preovulatory stage.
References
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Journal ArticleDOI
Growth differentiation factor-9 is required during early ovarian folliculogenesis
TL;DR: Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised, and GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo.
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Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.
S. M. Galloway,Kenneth P. McNatty,Lisa Cambridge,Mika Laitinen,Jennifer L. Juengel,T. S. Jokiranta,R. J. McLaren,Kaisu Luiro,Ken G. Dodds,Grant W. Montgomery,A. E. Beattie,George H. Davis,Olli Ritvos +12 more
TL;DR: It is established that BMP15 is essential for female fertility and that natural mutations in an ovary-derived factor can cause both increased ovulation rate and infertility phenotypes in a dosage-sensitive manner.
Journal ArticleDOI
Oocyte control of ovarian follicular development and function in mammals.
TL;DR: The existence of an oocyte-granulosa cell regulatory loop, essential for normal follicular differentiation as well as for the production of a oocyte competent to undergo fertilization and embryogenesis, is proposed.
Journal ArticleDOI
Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.
Changning Yan,Pei Wang,Janet L. DeMayo,Francesco J. DeMayo,Julia A. Elvin,Cecilia Carino,Sarvamangala V. Prasad,Sheri S. Skinner,Bonnie S. Dunbar,Jennifer L. Dube,Anthony J. Celeste,Martin M. Matzuk +11 more
TL;DR: The dosage of intact Bmp15 and Gdf9 alleles directly influences the destiny of the oocyte during folliculogenesis and in the periovulatory period, which has important implications for human fertility control and the maintenance of fertility and normal ovarian physiology.
Journal ArticleDOI
Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)
James P Hanrahan,Scott M. Gregan,Philippe Mulsant,Michael P. Mullen,George H. Davis,Richard Powell,S. M. Galloway +6 more
TL;DR: This is the first time that a mutation in the gene for GDF9 has been found that causes increased ovulation rate and infertility in a manner similar to inactivating mutations in BMP15, and shows that GDF 9 is essential for normal folliculogenesis in sheep.