Journal ArticleDOI
Oocyte–somatic cell interactions during follicle development in mammals
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TLDR
Elucidating the nature of oocyte-somatic cell interactions at the various stages of follicle development will have important implications for the understanding of factors regulating folliculogenesis, ovulation rate and fecundity.About:
This article is published in Animal Reproduction Science.The article was published on 2004-07-01. It has received 559 citations till now. The article focuses on the topics: Folliculogenesis & Granulosa cell.read more
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Journal ArticleDOI
Effect of bovine age on the proliferative activity, global DNA methylation, relative telomere length and telomerase activity of granulosa cells
Hiroya Goto,Hisataka Iwata,Shun Takeo,Keiko Nisinosono,Sayoko Murakami,Yasunori Monji,Takehito Kuwayama +6 more
TL;DR: The proliferative activity and genomic global DNA methylation significantly decreased, and the relative telomere lengths and telomerase activity of granulosa cells tended to be shorter with the age of donor cows.
Journal ArticleDOI
Lipid Identification and Transcriptional Analysis of Controlling Enzymes in Bovine Ovarian Follicle.
Priscila Silvana Bertevello,Ana-Paula Teixeira-Gomes,Alexandre Seyer,Anaïs Vitorino Carvalho,Anaïs Vitorino Carvalho,Valérie Labas,Marie-Claire Blache,Charles Banliat,Luiz Cordeiro,Véronique Duranthon,Pascal Papillier,Virginie Maillard,Sébastien Elis,Svetlana Uzbekova +13 more
TL;DR: Analysis of lipid composition and the transcriptional regulation of FA metabolism in 3–8 mm ovarian follicles in bovine suggest that the ovarian follicle contains the metabolic machinery that is potentially capable of metabolizing FA from nutrient uptake, degrading and producing lipoproteins, performing de novo lipogenesis, and accumulating lipid reserves, thus assuring oocyte energy supply, membrane synthesis, and lipid-mediated signaling to maintain follicular homeostasis.
Journal ArticleDOI
Aberrant spindle structures responsible for recurrent human metaphase I oocyte arrest with attempts to induce meiosis artificially
Björn Heindryckx,Sylvie Lierman,Catherine M.H. Combelles,C.A. Cuvelier,Jan Gerris,P. De Sutter +5 more
TL;DR: In this paper, the authors attempted to induce first polar body extrusion and fertilization using assisted oocyte activation (AOA) after ICSI in maturation-resistant human MI oocytes.
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Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth.
Agnès Bonnet,Bertrand Servin,Bertrand Servin,Philippe Mulsant,Philippe Mulsant,Beatrice Mandon-Pepin +5 more
TL;DR: The expression of genes such as Kruppel-like factor 9 (KLF9) and BMP binding endothelial regulator (BMPER) was highlighted for the first time during early follicular development, and their proteins were also predicted to be involved in gene regulation.
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Establishment and validation of a model for non-luteinized human mural granulosa cell culture.
Libby Ophir,Yuval Yung,Yuval Yung,Ettie Maman,N. Rubinstein,Gil M. Yerushalmi,Jigal Haas,Eran Barzilay,Ariel Hourvitz +8 more
TL;DR: It is shown that early-non-luteinized, preovulatory- non-luteninized and luteal-MGCs have distinct gene expression pattern, which may provide a standardized research tool for delineation of the molecular processes occurring during the latter stages of follicular development in the human ovary.
References
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Journal ArticleDOI
Growth differentiation factor-9 is required during early ovarian folliculogenesis
TL;DR: Oocyte growth and zona pellucida formation proceed normally, but other aspects of oocyte differentiation are compromised, and GDF-9 is the first oocyte-derived growth factor required for somatic cell function in vivo.
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Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.
S. M. Galloway,Kenneth P. McNatty,Lisa Cambridge,Mika Laitinen,Jennifer L. Juengel,T. S. Jokiranta,R. J. McLaren,Kaisu Luiro,Ken G. Dodds,Grant W. Montgomery,A. E. Beattie,George H. Davis,Olli Ritvos +12 more
TL;DR: It is established that BMP15 is essential for female fertility and that natural mutations in an ovary-derived factor can cause both increased ovulation rate and infertility phenotypes in a dosage-sensitive manner.
Journal ArticleDOI
Oocyte control of ovarian follicular development and function in mammals.
TL;DR: The existence of an oocyte-granulosa cell regulatory loop, essential for normal follicular differentiation as well as for the production of a oocyte competent to undergo fertilization and embryogenesis, is proposed.
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Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.
Changning Yan,Pei Wang,Janet L. DeMayo,Francesco J. DeMayo,Julia A. Elvin,Cecilia Carino,Sarvamangala V. Prasad,Sheri S. Skinner,Bonnie S. Dunbar,Jennifer L. Dube,Anthony J. Celeste,Martin M. Matzuk +11 more
TL;DR: The dosage of intact Bmp15 and Gdf9 alleles directly influences the destiny of the oocyte during folliculogenesis and in the periovulatory period, which has important implications for human fertility control and the maintenance of fertility and normal ovarian physiology.
Journal ArticleDOI
Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)
James P Hanrahan,Scott M. Gregan,Philippe Mulsant,Michael P. Mullen,George H. Davis,Richard Powell,S. M. Galloway +6 more
TL;DR: This is the first time that a mutation in the gene for GDF9 has been found that causes increased ovulation rate and infertility in a manner similar to inactivating mutations in BMP15, and shows that GDF 9 is essential for normal folliculogenesis in sheep.