Journal ArticleDOI
Origin of the HIV-susceptible human CD4+ cell line H9.
Dean L. Mann,Stephen J. O'Brien,Dennis A. Gilbert,Yvonne Reid,Mikulas Popovic,Elizabeth Read-Connole,Robert C. Gallo,Adi F. Gazdar +7 more
About:
This article is published in AIDS Research and Human Retroviruses.The article was published on 1989-06-01. It has received 152 citations till now. The article focuses on the topics: Line (text file).read more
Citations
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Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI.
TL;DR: The results suggest that the genotypes of some viruses in vitro are not stable and that selection for growth can cause the fairly rapid appearance of variants with increased growth potential.
Journal ArticleDOI
High-Titer Human Immunodeficiency Virus Type 1-Based Vector Systems for Gene Delivery into Nondividing Cells
TL;DR: The improved vector system used to generate pseudotyped HIV-1 particles successfully transduced contact-inhibited primary human skin fibroblasts and postmitotic rat cerebellar neurons and cardiac myocytes, a process not affected by the lack of the accessory proteins.
Journal ArticleDOI
Follicular dendritic cells and human immunodeficiency virus infectivity
TL;DR: It is reported here that HIV on FDC is highly infectious and FDC can convert neutralized HIV into an infectious form even in the presence of a vast excess of neutralizing antibody.
Journal ArticleDOI
Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles
TL;DR: The use of metabolic inhibitors or specific envelope/receptor antibodies and electron microscopic analyses revealed that the cell-to-cell spread of HIV required: (1) gp120-CD4 interaction and (2) reverse transcription.
Book
DNA Fingerprinting: Approaches and Applications
TL;DR: The generation of variability at VNTR loci in human DNA and the isolation and characterisation of plant sequences homologous to human hypervariable minisatellites are studied.
References
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Hypervariable 'minisatellite' regions in human DNA.
TL;DR: A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Journal ArticleDOI
Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS
TL;DR: A cell system was developed for the reproducible detection of human T-lymphotropic retroviruses (HTLV family) from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS), and it provides large amounts of virus for detailed molecular and immunological analyses.
Journal ArticleDOI
Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus)
Mikulas Popovic,Prem S. Sarin,M Robert-Gurroff,V. S. Kalyanaraman,Dean L. Mann,Jun Minowada,Robert C. Gallo +6 more
TL;DR: Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T- cell leukemia patient.
Journal ArticleDOI
Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas.
Adi F. Gazdar,Desmond N. Carney,Desmond N. Carney,Paul A. Bunn,Paul A. Bunn,Edward K. Russell,Edward K. Russell,Elaine S. Jaffe,Elaine S. Jaffe,Geraldine P. Schechter,Geraldine P. Schechter,John G. Guccion,John G. Guccion +12 more
TL;DR: In this article, the authors attempted to generate continuous in vitro cultures from patients with mycosis fungoides and the Sezary syndrome (cutaneous T-cell lymphomas, CTCL).
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Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS
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Lee Ratner,William A. Haseltine,Roberto Patarca,Kenneth J. Livak,Bruno Starcich,Steven F. Josephs,Ellen R. Doran,J. Antoni Rafalski,Erik A. Whitehorn,Kirk Baumeister,Lucinda A. Ivanoff,Stephen R. Petteway,Mark L. Pearson,James A. Lautenberger,Takis S. Papas,John Ghrayeb,Nancy T. Chang,Robert C. Gallo,Flossie Wong-Staal +18 more