Osteoarthritis of the spine: the facet joints
TLDR
The view that the modern concept of FJ OA is consonant with the concept of OA as a failure of the whole joint, and not simply of facet joint cartilage is presented.Abstract:
Osteoarthritis (OA) of the spine involves the facet joints, which are located in the posterior aspect of the vertebral column and, in humans, are the only true synovial joints between adjacent spinal levels. Facet joint osteoarthritis (FJ OA) is widely prevalent in older adults, and is thought to be a common cause of back and neck pain. The prevalence of facet-mediated pain in clinical populations increases with increasing age, suggesting that FJ OA might have a particularly important role in older adults with spinal pain. Nevertheless, to date FJ OA has received far less study than other important OA phenotypes such as knee OA, and other features of spine pathoanatomy such as degenerative disc disease. This Review presents the current state of knowledge of FJ OA, including relevant anatomy, biomechanics, epidemiology, and clinical manifestations. We present the view that the modern concept of FJ OA is consonant with the concept of OA as a failure of the whole joint, and not simply of facet joint cartilage.read more
Citations
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Toward a Mechanism-Based Approach to Pain Diagnosis
TL;DR: How identifying the specific mechanisms that operate in the nervous system to produce chronic pain in individual patients could provide the basis for a targeted and rational precision medicine approach to controlling pain is discussed, using chronic low back pain as an example.
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Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis.
TL;DR: This review summarises the microstructural and histopathological changes in subchondral bone during OA progression that are due, at the cellular level, to changes in the interactions among osteocytes, osteoblasts, osteoclasts (OCs), endothelial cells and sensory neurons and proposes the concept of ‘OC–CC crosstalk’.
Journal ArticleDOI
Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group.
Steven P Cohen,Arun Bhaskar,Anuj Bhatia,Asokumar Buvanendran,Tim Deer,Shuchita Garg,W. Michael Hooten,Robert W. Hurley,David J Kennedy,Brian C McLean,Jee Youn Moon,Samer Narouze,Sanjog Pangarkar,David A. Provenzano,Richard Rauck,B. Todd Sitzman,Matthew Smuck,Jan Van Zundert,Kevin E. Vorenkamp,Mark S. Wallace,Zirong Zhao +20 more
TL;DR: Lumbar medial branch RFA may provide benefit to well-selected individuals, with MBB being more predictive than IA injections, and more stringent selection criteria are likely to improve denervation outcomes, but at the expense of more false-negatives.
Journal ArticleDOI
A Systematic Review and Best Evidence Synthesis of the Effectiveness of Therapeutic Facet Joint Interventions in Managing Chronic Spinal Pain.
Laxmaiah Manchikanti,Alan D. Kaye,Mark V. Boswell,Sanjay Bakshi,Christopher Gharibo,Vahid Grami,Jay S. Grider,Sanjeeva Gupta,Sachin Sunny Jha,Dharam P Mann,Devi E. Nampiaparampil,Manohar Sharma,Lindsay N Shroyer,Vijay P. Singh,Amol Soin,Ricardo Vallejo,Bradley W. Wargo,Joshua A Hirsch +17 more
TL;DR: Based on the present assessment for the management of spinal facet joint pain, the evidence for long-term improvement is Level II for lumbar and cervical radiofrequency neurotomy, and therapeutic facet joint nerve blocks in the cervical, thoracic, andlumbar spine.
Journal ArticleDOI
Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.
Pradeep Suri,Pradeep Suri,Melody R. Palmer,Yakov A. Tsepilov,Maxim B. Freidin,Cindy G. Boer,Michelle S. Yau,Daniel S. Evans,Andrea Gelemanović,Traci M. Bartz,Maria Nethander,Liubov Arbeeva,Lennart C. Karssen,Tuhina Neogi,Archie Campbell,Dan Mellström,Claes Ohlsson,Lynn M. Marshall,Eric S. Orwoll,André G. Uitterlinden,Jerome I. Rotter,Gordan Lauc,Bruce M. Psaty,Bruce M. Psaty,Magnus Karlsson,Nancy E Lane,Gail P. Jarvik,Ozren Polasek,Marc C. Hochberg,Joanne M. Jordan,Joyce B. J. van Meurs,Rebecca D. Jackson,Carrie M. Nielson,Braxton D. Mitchell,Braxton D. Mitchell,Blair H. Smith,Caroline Hayward,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Yurii S. Aulchenko,Frances M K Williams +41 more
TL;DR: This first reported meta-analysis of GWAS for CBP identified and replicated a genetic locus associated with CBP (SOX5), and identified 2 other loci that reached genome-wide significance in a 2-stage joint meta- analysis (CCDC26/GSDMC and DCC).
References
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Journal ArticleDOI
Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States
Reva C. Lawrence,Charles G. Helmick,Frank C. Arnett,Richard A. Deyo,David T. Felson,Edward H. Giannini,Stephen P. Heyse,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Matthew H. Liang,Stanley R. Pillemer,Virginia D. Steen,Frederick Wolfe +13 more
TL;DR: Given the limitations of the data on which they are based, this report provides the best available prevalence estimates for arthritis and other rheumatic conditions overall, and for selected musculoskeletal disorders, in the US population.
Book
Clinical Biomechanics of the Spine
TL;DR: Combining orthopedic surgery with biomechanical engineering, this reference and teaching text reviews and analyzes the clinical and scientific data on the mechanics of the human spine.
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The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis
TL;DR: This is the first demonstration that in primary knee OA varus alignment increases risk of medial OA progression, that valgus alignment increased risk of lateral OA progress, that burden of malalignment predicts decline in physical function, and that these effects can be detected after as little as 18 months of observation.
Journal ArticleDOI
A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
Velandai Srikanth,Jayne L. Fryer,Guangju Zhai,Tania Winzenberg,David W. Hosmer,David W. Hosmer,Graeme Jones +6 more
TL;DR: The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk and females also tend to have more severe knee OA, particularly after menopausal age.
Journal ArticleDOI
The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis
David T. Felson,Christine E. Chaisson,Christopher Hill,Saara Totterman,M. Elon Gale,Katherine M. Skinner,Lewis E. Kazis,Daniel Gale +7 more
TL;DR: This data suggests that in some patients, pain originates from extraarticular, noncapsular sources, one of the most likely of which is bone, and suggests that for these patients, anti-inflammatory treatments targeted at synovitis or intra-articular drainage to relieve capsular distention would be ineffective.