Overview of general physiologic features and functions of vitamin D
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TLDR
An overview of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D is provided and information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy is provided.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2004-12-01 and is currently open access. It has received 2092 citations till now. The article focuses on the topics: Kidney metabolism & Intestinal absorption.read more
Citations
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Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline
Michael F. Holick,Neil Binkley,Heike A. Bischoff-Ferrari,Catherine M. Gordon,David A. Hanley,Robert P. Heaney,M. Hassan Murad,Connie M. Weaver +7 more
TL;DR: Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances.
Journal Article
Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline (Journal of Clinical Endocrinology and Metabolism (2011) 96, (1911-1930))
Michael F. Holick,Neil Binkley,Heike A. Bischoff-Ferrari,Catherine M. Gordon,David A. Hanley,Robert P. Heaney,M. Hassan Murad,Connie M. Weaver +7 more
TL;DR: The Task Force as discussed by the authors provided guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency, based on systematic reviews of evidence and discussions during several conference calls and e-mail communications.
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Vitamin D deficiency : a worldwide problem with health consequences
Michael F. Holick,Tai C. Chen +1 more
TL;DR: Vitamin D deficiency causes rickets in children and will precipitate and exacerbate osteopenia, osteoporosis, and fractures in adults, and foods that are fortified with vitamin D are often inadequate to satisfy either a child's or an adult's vitamin D requirement.
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High prevalence of vitamin D inadequacy and implications for health.
TL;DR: The purposes of this article are to examine the prevalence of vitamin D inadequacy and to review the potential implications for skeletal and extraskeletal health.
References
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Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
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Current Understanding of the Molecular Actions of Vitamin D
TL;DR: This review raises the intriguing question of whether vitamin D plays an important role in embryonic development, since vitamin D deficiency does not prohibit development, nor does vitamin D receptor knockout.
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1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
TL;DR: 1,25-dihydroxyvitamin D3 or its analogs are potentially important for treatment of MS because a deficiency of vitamin D resulted in an increased susceptibility to EAE.
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Control of 25-hydroxycholecalciferol metabolism by parathyroid glands.
TL;DR: It appears that the parathyroid hormone serves as a tropin for production of 1,25-dihydroxycholecalciferol, the hormonal form of vitamin D responsible for calcium mobilization from intestinal contents and bone.
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Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo
TL;DR: It is concluded that 1α,25(OH)2D3/VDR mediates physiologically relevant inhibition of DC maturity that is resistant to maturational stimuli and modulates antigen-specific immune responses in vivo.