Oxyresveratrol and Hydroxystilbene Compounds INHIBITORY EFFECT ON TYROSINASE AND MECHANISM OF ACTION
TLDR
The depigmenting effect of oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-05-03 and is currently open access. It has received 322 citations till now. The article focuses on the topics: Oxyresveratrol & Tyrosinase.read more
Citations
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Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
Bharat B. Aggarwal,Anjana Bhardwaj,Rishi S. Aggarwal,Navindra P. Seeram,Shishir Shishodia,Yasunari Takada +5 more
TL;DR: In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
Journal ArticleDOI
An Updated Review of Tyrosinase Inhibitors
TL;DR: This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed.
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Chemical and Instrumental Approaches to Treat Hyperpigmentation
TL;DR: This review describes the different approaches to obtain depigmentation, suggests a classification of whitening molecules on the basis of the mechanism by which they interfere with melanogenesis, and confirms the necessity to apply standardized protocols to evaluate depigmenting treatments.
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Hypopigmenting agents: an updated review on biological, chemical and clinical aspects
TL;DR: An overview of agents causing hypopigmentation in human skin is presented and it is suggested that Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase.
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A comprehensive review on tyrosinase inhibitors.
Samaneh Zolghadri,Asieh Bahrami,Mahmud Tareq Hassan Khan,Jose Munoz-Munoz,Francisco Garcia-Molina,Francisco García-Cánovas,Ali Akbar Saboury +6 more
TL;DR: This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.
References
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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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Biological effects of resveratrol.
TL;DR: Resveratrol has been shown to modulate the metabolism of lipids, and to inhibit the oxidation of low-density lipoproteins and the aggregation of platelets, and may play a role in the prevention of human cardiovascular diseases.
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Biological mediators of insect immunity
TL;DR: A component of insect immune responses to bacteria is the synthesis by fat body and hemocytes of a variety of antibacterial proteins and peptides, which are secreted into the hemolymph.
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Inhibition of carcinogenesis by dietary polyphenolic compounds
TL;DR: This chapter reviews the inhibition of tumorigenesis by phenolic acids and derivatives, tea and catechins, isoflavones and soy preparations, quercetin and other flavonoids, resveratrol, and lignans as well as the mechanisms involved based on studies in vivo and in vitro.
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Cyclic AMP a Key Messenger in the Regulation of Skin Pigmentation
Roser Buscà,Robert Ballotti +1 more
TL;DR: It appears that melanogenic gene expression is controlled by a complex network of regulation involving other transcription factors such as Brn2, TBX2, PAX3 and SOX10, which would finally allow a fine tuning of melanocyte differentiation leading to melanin synthesis.
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