Journal ArticleDOI
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)
Jacob Schachter,Antoni Ribas,Georgina V. Long,Ana Arance,Jean-Jacques Grob,Laurent Mortier,Adil Daud,Matteo S. Carlino,Catriona M. McNeil,Michal Lotem,James Larkin,Paul Lorigan,Bart Neyns,Christian U. Blank,Teresa M. Petrella,Omid Hamid,Honghong Zhou,Scot Ebbinghaus,Nageatte Ibrahim,Caroline Robert +19 more
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The final protocol-specified survival analysis as mentioned in this paper showed that pembrolizumab continued to provide superior overall survival versus ipilimumab, with no difference between the two dosing schedules.About:
This article is published in The Lancet.The article was published on 2017-10-21. It has received 904 citations till now. The article focuses on the topics: Pembrolizumab & Ipilimumab.read more
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Journal ArticleDOI
Increasing Costs of Skin Cancer due to Increasing Incidence and Introduction of Pharmaceuticals, 2007-2017
E C Noels,Loes M. Hollestein,Kees Luijkx,Marieke W. J. Louwman,Carin de Uyl-de Groot,Renate van den Bos,Astrid A.M. van der Veldt,Dirk J. Grünhagen,Marlies Wakkee +8 more
TL;DR: The increasing costs of skin cancer are strongly affected by the increasing incidence and introduction of expensive drugs, and future projections are for an alarming increase.
Journal ArticleDOI
[The revolution of immuno-oncology therapy: review of immune checkpoint inhibitors efficacy].
TL;DR: L’immunotherapie anti-tumorale represente un changement de paradigme majeur ou le traitement ne cible plus directement les cellules tumorales mais le patient lui-meme, afin de restaurer une immunite anti-Tumorales efficace.
Journal ArticleDOI
Treatment Options for Advanced Melanoma After Anti-PD-1 Therapy.
TL;DR: This paper reviewed the post anti-PD-1 therapy alternatives that may be possible for patients with unresectable or metastatic stage 3 or 4 melanoma, and found that a substantial proportion of patients are still refractory to or progress after treatment with anti- PD-1 immunotherapy.
Journal ArticleDOI
Carbon-ion radiotherapy combined with chemotherapy for head and neck mucosal melanoma: Prospective observational study.
Yukihiro Takayasu,Nobuteru Kubo,Masato Shino,Osamu Nikkuni,Shota Ida,Atsushi Musha,Katsumasa Takahashi,Junko Hirato,Katsuyuki Shirai,Jun-ichi Saitoh,Satoshi Yokoo,Kazuaki Chikamatsu,Tatsuya Ohno,Takashi Nakano,Neck Tumors +14 more
TL;DR: Carbon‐ion radiotherapy in combination with DAV therapy led to excellent local control for advanced mucosal melanoma within acceptable toxicities, which was weaker than expected as distant metastases still occurred frequently.
Journal ArticleDOI
The patient perspective in the era of personalized medicine: What about scanxiety?
José A. E. Custers,Lucy Davis,Christina Messiou,Judith B. Prins,Winette T. A. van der Graaf,Winette T. A. van der Graaf +5 more
TL;DR: Frequency of scans has accelerated in the era of personalized medicine and is related to the exploding number of clinical trials for new cancer treatments as discussed by the authors, particularly in drug trials, but also in clinical practice, patients are followed up by scans frequently, which may vary from every 6 to 12 weeks until progression.
References
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Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
Journal ArticleDOI
The blockade of immune checkpoints in cancer immunotherapy
TL;DR: Preliminary clinical findings with blockers of additional immune-checkpoint proteins, such as programmed cell death protein 1 (PD1), indicate broad and diverse opportunities to enhance antitumour immunity with the potential to produce durable clinical responses.
Journal ArticleDOI
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
James Larkin,Vanna Chiarion-Sileni,Rene Gonzalez,Jean-Jacques Grob,C. Lance Cowey,Christopher D. Lao,Dirk Schadendorf,Reinhard Dummer,Michael Smylie,Piotr Rutkowski,Pier Francesco Ferrucci,A. Hill,John Wagstaff,Matteo S. Carlino,John B A G Haanen,Michele Maio,Ivan Marquez-Rodas,Grant A. McArthur,Paolo A. Ascierto,Georgina V. Long,Margaret K. Callahan,Michael A. Postow,Michael A. Postow,Kenneth F. Grossmann,Mario Sznol,Brigitte Dréno,Lars Bastholt,Arvin Yang,Linda Rollin,Christine Horak,F. Stephen Hodi,Jedd D. Wolchok,Jedd D. Wolchok +32 more
TL;DR: Among previously untreated patients with metastatic melanoma, nivolumab alone or combined with ipilimumab resulted in significantly longer progression-free survival than ipILimumab alone, and in patients with PD-L1-negative tumors, the combination of PD-1 and CTLA-4 blockade was more effective than either agent alone.
Journal ArticleDOI
Pembrolizumab versus Ipilimumab in Advanced Melanoma
Caroline Robert,Caroline Robert,Caroline Robert,Jacob Schachter,Georgina V. Long,Ana Arance,Jean-Jacques Grob,Laurent Mortier,Laurent Mortier,Adil Daud,Matteo S. Carlino,Catriona M. McNeil,Michal Lotem,James Larkin,Paul Lorigan,Bart Neyns,Christian U. Blank,Omid Hamid,Christine Mateus,Christine Mateus,Ronnie Shapira-Frommer,Ronnie Shapira-Frommer,Michele Kosh,Honghong Zhou,Nageatte Ibrahim,Scot Ebbinghaus,Antoni Ribas +26 more
TL;DR: The anti-PD-1 antibody pembrolizumab prolonged progression-free survival and overall survival and had less high-grade toxicity than did ipilimumab in patients with advanced melanoma.
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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
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Pembrolizumab versus Ipilimumab in Advanced Melanoma
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