Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence in Boise, Idaho.
Andrew Bryan,Gregory Pepper,Mark H. Wener,Susan L. Fink,Chihiro Morishima,Anu Chaudhary,Keith R. Jerome,Keith R. Jerome,Patrick C. Mathias,Alexander L. Greninger,Alexander L. Greninger +10 more
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It is expected that the availability of high-quality serological testing will be a key tool in the fight against SARS-CoV-2 as the limited circulation of the virus in the western United States.Abstract:
Coronavirus disease 2019 (COVID-19), the novel respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with severe morbidity and mortality. The rollout of diagnostic testing in the United States was slow, leading to numerous cases that were not tested for SARS-CoV-2 in February and March 2020 and necessitating the use of serological testing to determine past infections. Here, we evaluated the Abbott SARS-CoV-2 IgG test for detection of anti-SARS-CoV-2 IgG antibodies by testing 3 distinct patient populations. We tested 1,020 serum specimens collected prior to SARS-CoV-2 circulation in the United States and found one false positive, indicating a specificity of 99.90%. We tested 125 patients who tested reverse transcription-PCR (RT-PCR) positive for SARS-CoV-2 for whom 689 excess serum specimens were available and found that sensitivity reached 100% at day 17 after symptom onset and day 13 after PCR positivity. Alternative index value thresholds for positivity resulted in 100% sensitivity and 100% specificity in this cohort. We tested specimens from 4,856 individuals from Boise, ID, collected over 1 week in April 2020 as part of the Crush the Curve initiative and detected 87 positives for a positivity rate of 1.79%. These data demonstrate excellent analytical performance of the Abbott SARS-CoV-2 IgG test as well as the limited circulation of the virus in the western United States. We expect that the availability of high-quality serological testing will be a key tool in the fight against SARS-CoV-2.read more
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Mental Health, Substance Use, and Suicidal Ideation During the COVID-19 Pandemic - United States, June 24-30, 2020.
Mark É Czeisler,Rashon I. Lane,Emiko Petrosky,Joshua F. Wiley,Aleta Christensen,Rashid Njai,Matthew D. Weaver,Matthew D. Weaver,Rebecca Robbins,Rebecca Robbins,Elise R Facer-Childs,Laura K. Barger,Laura K. Barger,Charles A. Czeisler,Charles A. Czeisler,Charles A. Czeisler,Mark E Howard,Shantha M W Rajaratnam,Shantha M W Rajaratnam +18 more
TL;DR: Community-level intervention and prevention efforts, including health communication strategies, designed to reach these groups could help address various mental health conditions associated with the COVID-19 pandemic.
Journal ArticleDOI
Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study.
Marina Pollán,Beatriz Pérez-Gómez,Roberto Pastor-Barriuso,Jesús Oteo,Miguel A. Hernán,Miguel A. Hernán,Mayte Pérez-Olmeda,Jose L Sanmartín,Aurora Fernández-García,Aurora Fernández-García,Israel Cruz,Nerea Fernández de Larrea,Marta Molina,Francisco Rodríguez-Cabrera,Mariano Martín,Paloma Merino-Amador,Jose León Paniagua,Juan F Muñoz-Montalvo,Faustino Blanco,Raquel Yotti,Rodrigo Gutiérrez Fernández,Saturnino Mezcua Navarro,Matías Salinero Hernández,Manuel Cuenca-Estrella,Pablo Fernández-Navarro,Ana Avellón,Giovanni Fedele,Jesús Oteo Iglesias,María Teresa Pérez Olmeda,Maria Elena Martinez,Francisco D. Rodríguez-Cabrera,Susana Padrones Fernández,José Manuel Rumbao Aguirre,José M. Navarro Marí,Begoña Palop Borrás,Ana Belén Pérez Jiménez,Manuel Rodríguez-Iglesias,Ana María Calvo Gascón,María Luz Lou Alcaine,Ignacio Donate Suárez,Oscar Suárez Álvarez,Mercedes Rodríguez Pérez,Margarita Cases Sanchís,Carlos Javier Villafáfila Gomila,Lluis Carbo Saladrigas,Adoración Hurtado Fernández,Antonio Oliver,Elías Castro Feliciano,María Noemí González Quintana,José María Barrasa Fernández,María Araceli Hernández Betancor,Melisa Hernández Febles,Leopoldo Martín Martín,Luis-Mariano López López,Teresa Ugarte Miota,Inés De Benito Población,María Sagrario Celada Pérez,María Natalia Vallés Fernández,Tomás Maté Enríquez,Miguel Villa Arranz,Marta Domínguez-Gil González,Isabel Fernández-Natal,Gregoria Megías Lobón,Juan Luis Muñoz Bellido,Pilar Ciruela,Ariadna Mas i Casals,Maria Doladé Botías,M. Angeles Marcos Maeso,Dúnia Pérez del Campo,Antonio Félix de Castro,Ramón Limón Ramírez,Maria Francisca Elías Retamosa,Manuela Rubio González,María Sinda Blanco Lobeiras,Alberto Fuentes Losada,Antonio Aguilera,Germán Bou,Yolanda Caro,Noemí Marauri,Luis Miguel Soria Blanco,Isabel González,Montserrat Hernández Pascual,Roberto Alonso Fernández,Natalia Cabrera Castro,Aurora Tomás Lizcano,Cristóbal Ramírez Almagro,M. Hernández,Nieves Ascunce Elizaga,María Ederra Sanz,Carmen Ezpeleta Baquedano,Ana Bustinduy Bascaran,Susana Iglesias Tamayo,Luis Elorduy Otazua,Rebeca Benarroch Benarroch,Jesús Lopera Flores,Antonia Vázquez de la Villa +95 more
TL;DR: In this paper, a nationwide population-based study aims to estimate the seroprevalence of SARS-CoV-2 infection in Spain at national and regional level.
Journal ArticleDOI
Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study.
Julie Toubiana,Julie Toubiana,Clément Poirault,Alice Corsia,Fanny Bajolle,Jacques Fourgeaud,François Angoulvant,Agathe Debray,Romain Basmaci,Elodie Salvador,Sandra Biscardi,Pierre Frange,Martin Chalumeau,Jean-Laurent Casanova,Jean-Laurent Casanova,Jérémie F. Cohen,Slimane Allali +16 more
TL;DR: An unusually high proportion of the affected children and adolescents had gastrointestinal symptoms, Kawasaki disease shock syndrome, and were of African ancestry in this study, suggesting that the ongoing outbreak of Kawasaki-like multisystem inflammatory syndrome in the Paris area might be related to SARS-CoV-2.
Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study
Marina Pollán,Beatriz Pérez-Gómez,Roberto Pastor-Barriuso,Jesús Oteo,Miguel A. Hernán,Mayte Pérez-Olmeda,Jose L Sanmartín,Aurora Fernández-García,Israel Cruz,Nerea Fernández de Larrea,Marta Molina,Francisco Rodríguez-Cabrera,Mariano Martín,Paloma Merino-Amador,Jose León Paniagua,Juan F Muñoz-Montalvo,Faustino Blanco,Raquel Yotti +17 more
TL;DR: The majority of the Spanish population is seronegative to SARS-CoV-2 infection, even in hotspot areas, and results emphasise the need for maintaining public health measures to avoid a new epidemic wave.
Journal ArticleDOI
Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications.
Andrew T. Levin,Andrew T. Levin,William P. Hanage,Nana Owusu-Boaitey,Kensington B. Cochran,Seamus P. Walsh,Gideon Meyerowitz-Katz +6 more
TL;DR: The results indicate that COVID-19 is hazardous not only for the elderly but also for middle-aged adults, for whom the infection fatality rate is two orders of magnitude greater than the annualized risk of a fatal automobile accident and far more dangerous than seasonal influenza.
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