Causes, consequences, and reversal of immune system aging
TLDR
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues, and elderly individuals do not respond to immune challenge as robustly as the young.Abstract:
The effects of aging on the immune system are manifest at multiple levels that include reduced production of B and T cells in bone marrow and thymus and diminished function of mature lymphocytes in secondary lymphoid tissues. As a result, elderly individuals do not respond to immune challenge as robustly as the young. An important goal of aging research is to define the cellular changes that occur in the immune system and the molecular events that underlie them. Considerable progress has been made in this regard, and this information has provided the rationale for clinical trials to rejuvenate the aging immune system.read more
Citations
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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TL;DR: It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
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Performance Characteristics of the Abbott Architect SARS-CoV-2 IgG Assay and Seroprevalence in Boise, Idaho.
Andrew Bryan,Gregory Pepper,Mark H. Wener,Susan L. Fink,Chihiro Morishima,Anu Chaudhary,Keith R. Jerome,Keith R. Jerome,Patrick C. Mathias,Alexander L. Greninger,Alexander L. Greninger +10 more
TL;DR: It is expected that the availability of high-quality serological testing will be a key tool in the fight against SARS-CoV-2 as the limited circulation of the virus in the western United States.
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Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.
Ellen Shrock,Ellen Shrock,Eric Fujimura,Eric Fujimura,Tomasz Kula,Tomasz Kula,Richard T. Timms,Richard T. Timms,I-Hsiu Lee,Yumei Leng,Yumei Leng,Matthew L Robinson,Brandon M. Sie,Brandon M. Sie,Mamie Z. Li,Mamie Z. Li,Yuezhou Chen,Jennifer K. Logue,Adam Zuiani,Denise J. McCulloch,Felipe J.N. Lelis,Stephanie A. Henson,Daniel R. Monaco,Meghan Travers,Shaghayegh Habibi,William Clarke,Patrizio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Alicja Piechocka-Trocha,Jonathan Z. Li,Ashok Khatri,Helen Y. Chu,Alexandra-Chloé Villani,Kyle R. Kays,Marcia B. Goldberg,Nir Hacohen,Michael R. Filbin,Xu G. Yu,Bruce D. Walker,Bruce D. Walker,Duane R. Wesemann,H. Benjamin Larman,James A. Lederer,Stephen J. Elledge,Stephen J. Elledge +45 more
TL;DR: A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed, important for understanding the immunogenicity of the viral proteome and the basis for cross-reactivity with the common-cold coronaviruses.
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Unmasking senescence: context-dependent effects of SASP in cancer
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The mitochondrial UPR: mechanisms, physiological functions and implications in ageing
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