Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III
James M. Noble,Luisa N. Borrell,Panos N. Papapanou,Mitchell S.V. Elkind,Nikolaos Scarmeas,Clinton B. Wright +5 more
TLDR
A serological marker of periodontitis is associated with impaired delayed memory and calculation, and further exploration of relationships between oral health and cognition is warranted.Abstract:
Background: Periodontitis is ubiquitous and associated with serological evidence of exposure to periodontal organisms, systemic inflammation and vascular disease. Dementia is a major public health problem likely related to a complex interaction between genetics and diseases associated with systemic inflammation, including diabetes, smoking and stroke. Methods: To assess relationships between systemic exposure to periodontal pathogens and cognitive test outcomes, data were analysed from the Third National Health and Nutrition Examination Survey (NHANES-III), a nationally representative cross sectional observational study among older adults. We included 2355 participants ⩾60 years who completed measures of cognition and Poryphyromonas gingivalis IgG. Using SUDAAN, logistic regression models examined the association of P gingivalis IgG with cognitive test performance. Results: Poor immediate verbal memory ( P gingivalis IgG (>119 ELISA Units (EU)) were more likely to have poor delayed verbal recall (OR 2.89, 95% CI 1.14 to 7.29) and impaired subtraction (OR 1.95, 95% CI 1.22 to 3.11) than those with the lowest (⩽57 EU), with dose–response relationships for both (p trend, delayed memory = 0.045, subtraction = 0.04). After adjusting for socioeconomic and vascular variables, these relationships remained robust for the highest P gingivalis IgG group (delayed verbal memory OR 3.01 (95% CI 1.06 to 8.53); subtraction OR 2.00 (95% CI 1.19 to 3.36)). In contrast, immediate verbal memory was not significantly associated with P gingivalis . Conclusion: A serological marker of periodontitis is associated with impaired delayed memory and calculation. Further exploration of relationships between oral health and cognition is warranted.read more
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Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
Stephen S. Dominy,Casey C. Lynch,Florian Ermini,Malgorzata Benedyk,Agata Marczyk,Andrei Konradi,Mai Nguyen,Ursula Haditsch,Debasish Raha,Christina Griffin,Leslie J. Holsinger,Shirin Arastu-Kapur,Samer Kaba,Alexander Lee,Mark I. Ryder,Barbara Potempa,Piotr Mydel,Piotr Mydel,Annelie Hellvard,Annelie Hellvard,Karina Adamowicz,Hatice Hasturk,Hatice Hasturk,Glenn D Walker,Eric C. Reynolds,Richard L.M. Faull,Maurice A. Curtis,Mike Dragunow,Jan Potempa,Jan Potempa +29 more
TL;DR: Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors, suggesting that gingipain inhibitors could be valuable for treating P. gedivalis brain colonization and neurodegeneration in Alzheimer's disease.
Journal Article
Prevalence of periodontal disease, its association with systemic diseases and prevention.
TL;DR: It is hoped that medical, dental practitioners, and other health-care professionals will get familiar with perio-systemic link and risk factors, and need to refer to the specialized dental or periodontal care.
Journal ArticleDOI
Periodontal systemic associations: review of the evidence.
TL;DR: There is a need to reach a consensus on what constitutes periodontitis for future studies of putative associations with systemic diseases and there was substantial heterogeneity in the definitions used to identifyperiodontitis.
Journal ArticleDOI
The gut microbiome in human neurological disease: A review.
TL;DR: This review provides an overview of the recent advances in microbiome research in relation to neuro(auto)immune and neurodegenerative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica spectrum disorders, Parkinson disease, Alzheimer disease, Huntington disease, and amyotrophic lateral sclerosis.
Journal ArticleDOI
Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease
Pamela S. Stein,M. J. Steffen,Charles D. Smith,Gregory A. Jicha,Jeffrey L. Ebersole,Erin L. Abner,Dolph Dawson +6 more
TL;DR: In this paper, the authors examined serum antibody levels to bacteria associated with periodontal disease in participants who eventually converted to Alzheimer's disease compared with the antibody levels in control subjects.
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