Journal ArticleDOI
Persistent effect of in utero meso-2,3-dimercaptosuccinic acid (DMSA) on immune function and lead-induced immunotoxicity.
TLDR
The results suggest that DMSA reverses some of the lead-induced immunotoxicity; however, this treatment itself during embryonic development produces subsequent adult immunomodulation.About:
This article is published in Toxicology.The article was published on 1999-01-01. It has received 54 citations till now. The article focuses on the topics: Lead acetate & Offspring.read more
Citations
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Journal ArticleDOI
Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary.
Rodney R. Dietert,Ruth A. Etzel,David H. Chen,Marilyn Halonen,Steven D. Holladay,Annie M. Jarabek,Kenneth S. Landreth,David B. Peden,Kent E. Pinkerton,Ralph J. Smialowicz,Tracey Zoetis +10 more
TL;DR: Differential windows of vulnerability during development are identified in the context of available animal models as well as changes in target organ sensitivities to toxicant effects on the immune and respiratory systems.
Journal ArticleDOI
Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure
TL;DR: The available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life.
Journal ArticleDOI
Lead and immune function.
TL;DR: This review considers the animal and human evidence that lead exposure can produce a stark shift in immune functional capacity with a skewing predicted to elevate the risk of atopic and certain autoimmune diseases.
Journal ArticleDOI
Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender.
TL;DR: The results suggest that at the Pb dosage employed, the embryo may be more sensitive to the full range of Pb-induced immunotoxic effects with late gestational Pb exposure, and the effects of P b on DTH function are more pronounced in females.
Journal ArticleDOI
Developmental immunotoxicology of lead.
TL;DR: The existence of and probable basis for developmental windows of immune hyper-susceptibility are presented, and the potential for lead to serve as a perinatal risk factor for childhood asthma as well as other diseases is considered.
References
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Journal ArticleDOI
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Laura C. Green,David A. Wagner,Joseph A. Glogowski,Paul L. Skipper,John S. Wishnok,Steven R. Tannenbaum +5 more
TL;DR: A new automated system for the analysis of nitrate via reduction with a high-pressure cadmium column that automatically eliminates interference from other compounds normally present in urine and other biological fluids is described.
Journal ArticleDOI
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.
TL;DR: The inverse relationship of IFN-gamma and IL-4 gene expression during leishmaniasis may underlie the divergence of cellular and humoral immunity that occurs during chronic infection with Leishmania and possibly other intracellular parasites.
Journal ArticleDOI
Lead toxicity: current concerns.
TL;DR: A brief review identifies major advances as well as a number of current concerns that present opportunities for prevention and intervention strategies in lead toxicity in children and adults.
Journal ArticleDOI
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.
Mario Clerici,Frances T. Hakim,David Venzon,Stephen P. Blatt,Craig W. Hendrix,Thomas A. Wynn,Gene M. Shearer +6 more
TL;DR: The results suggest that the TH functions assessed by IL-4 production replace the normally dominant TH function of antigen-stimulated IL-2 production in the progression toward AIDS, and raise the possibility of cytokine cross-regulation in AIDS therapy.
Journal ArticleDOI
Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development.
Susan L. Swain,Linda M. Bradley,Michael Croft,Susan L. Tonkonogy,Gus Atkins,Andrew D. Weinberg,D D Duncan,Stephen M. Hedrick,Richard W. Dutton,Gail E. Huston +9 more
TL;DR: The studies suggest these emerging memory cells may be phenotypically unique and postulate that they are specialized to become a "long-lived" population of memory cells that will persist indefinitely as a protective population of increased frequency for the antigen encountered and which is also able to respond more rapidly and effectively.
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Effect of chronic developmental lead exposure on cell-mediated immune functions.
R E Faith,M I Luster,C A Kimmel +2 more