Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models.
Elisângela Saturnino de Souza Almeida,Valdir Cechinel Filho,Rivaldo Niero,Bruna Kurz Clasen,Sikiru Olaitan Balogun,Domingos Tabajara de Oliveira Martins +5 more
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TLDR
In this paper, the authors evaluated the pharmacological mechanism(s) of action of the antiulcer effects of the methanol extract of Simaba ferruginea and its alkaloid canthin-6-one.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2011-04-12 and is currently open access. It has received 62 citations till now.read more
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Journal ArticleDOI
Natural products in treatment of ulcerative colitis and peptic ulcer
TL;DR: The main concern of the current article is to introduce a safe drug (or more) of natural origin, to be used for the management of gastric ulcers without side effects.
Journal ArticleDOI
Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology.
TL;DR: More evidence is required regarding its therapeutic efficacy and safety, so it can be considered a rich herbal source of new drug candidates, and focus attention on its more active constituents.
Journal ArticleDOI
Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice.
TL;DR: Findings suggest that the gastroprotective activity of CHE might contribute in adjusting the inflammatory cytokine by regulating the NF-κB signalling pathway in mice exposed to ethanol induced ulceration.
Journal ArticleDOI
Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats.
Haiming Chen,Hui-Jun Liao,Yu-Hong Liu,Yi-Feng Zheng,Xiao-Li Wu,Zu-Qing Su,Xie Zhang,Zheng-Quan Lai,Xiao-Ping Lai,Zhi-Xiu Lin,Zi-Ren Su +10 more
TL;DR: Results strongly indicate that PO could exert a gastro-protective effect against gastric ulceration, and the underlying mechanism might be associated with the stimulation of PGE2, improvement of antioxidant and anti-inflammatory status, as well as preservation of NP-SH.
Journal ArticleDOI
Simaroubaceae family: botany, chemical composition and biological activities
Iasmine Andreza Basilio dos Santos Alves,Henrique Marcelino Miranda,Luiz Alberto Lira Soares,Karina Perrelli Randau +3 more
TL;DR: The present work reviews the information regarding the main genera of the Simaroubaceae up to 2013, characterized by the presence of quassinoids, secondary metabolites responsible of a wide spectrum of biological activities such as antitumor, antimalarial, antiviral, insecticide, feeding deterrent, amebicides and herbicidal.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Journal ArticleDOI
Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: Assessment of inflammation in rat and hamster models
TL;DR: In this paper, an assay was devised to quantitate acute intestinal inflammation based on the assessment of myeloperoxidase activity, an enzyme found in neutrophils and, in much smaller quantities, in monocytes and macrophages.
Journal ArticleDOI
Cytoprotection by Prostaglandins in Rats Prevention of Gastric Necrosis Produced by Alcohol, HCl, NaOH, Hypertonic NaCl, and Thermal Injury
TL;DR: In this paper, the authors show that prostaglandins, by a mechanism other than the inhibition of gastric acid secretion, maintain the cellular integrity of the gastric mucosa, and might be beneficial in the treatment of a variety of diseases in which gastric injury is present.
Journal Article
Peptic ulcer disease.
TL;DR: For younger patients with no alarm symptoms, a test-and-treat strategy based on the results of H. pylori testing is recommended as discussed by the authors, and patients with persistent symptoms should be referred for endoscopy.
Book ChapterDOI
Anti-ulcer drugs of plant origin.
D.A. Lewis,P.J. Hanson +1 more
TL;DR: This chapter describes both established and experimental anti-ulcer drugs from plants and attempts to relate structural features in active compounds to the pathology of peptic ulceration.