Journal ArticleDOI
Protective effect of chelerythrine against ethanol-induced gastric ulcer in mice.
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TLDR
Findings suggest that the gastroprotective activity of CHE might contribute in adjusting the inflammatory cytokine by regulating the NF-κB signalling pathway in mice exposed to ethanol induced ulceration.About:
This article is published in Chemico-Biological Interactions.The article was published on 2014-02-05. It has received 97 citations till now. The article focuses on the topics: Gastric mucosa & Ulcer index.read more
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Recent progress regarding kaempferol for the treatment of various diseases (Review)
TL;DR: Kaempferol has beneficial effects against cancer, liver injury, obesity and diabetes, inhibits vascular endothelial inflammation, protects the cranial nerve and heart function, and may be used for treating fibroproliferative disorders, including hypertrophic scar.
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Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion.
Mehdi Sharifi-Rad,Patrick Valere Tsouh Fokou,Farukh Sharopov,Miquel Martorell,Adedayo O. Ademiluyi,Jovana Rajkovic,Bahare Salehi,Natália Martins,Marcello Iriti,Javad Sharifi-Rad,Javad Sharifi-Rad +10 more
TL;DR: From traditional uses as herbal remedies to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential, comprehensively reviewed the plant sources used as antiulcers agents.
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Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation.
Hong Zheng,Yuling Chen,Jingze Zhang,Lei Wang,Zhaoxiang Jin,Hanhan Huang,Shuli Man,Wenyuan Gao +7 more
TL;DR: It is suggested that Co or De could be a new useful natural gastroprotective tool against gastric ulcer, which provided a scientific basis for the gastroprotection of sesquiterpene lactones.
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Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms
TL;DR: Western blot results consistently demonstrated that butyrate pretreatment attenuated the phosphorylation of NF-κB p65, p38 MAPK and ERKs in the gastric tissues, and gastric wall mucus, a parameter reflecting mucosal defense, was clearly increased by butyrates pretreatment.
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Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats.
Saad B. Almasaudi,Aymn T. Abbas,Rashad R. Al-Hindi,Nagla A. El-Shitany,Umama A. Abdel-dayem,Soad Shaker Ali,Rasha M. Saleh,Soad K. Al Jaouni,Mohammad Amjad Kamal,Steve Harakeh +9 more
TL;DR: Manuka honey is effective in the treatment of chronic ulcer and preservation of mucosal glycoproteins due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.
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THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
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Nitric oxide and macrophage function
TL;DR: Although the high-output NO pathway probably evolved to protect the host from infection, suppressive effects on lymphocyte proliferation and damage to other normal host cells confer upon NOS2 the same protective/destructive duality inherent in every other major component of the immune response.
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Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker
TL;DR: It is demonstrated that MPO can be used as a marker for skin neutrophil content: it is recoverable from skin in soluble form, and is directly related to neutrophIL number.
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Nitric oxide and the immune response
TL;DR: Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications.
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Nitric oxide synthase: role in the genesis of vascular disease.
John P. Cooke,Victor J. Dzau +1 more
TL;DR: Insights into the mechanisms by which NO production or activity is altered in these states will lead to new therapeutic strategies in the treatment of a number of vascular disorders, including hypertension, atherosclerosis, restenosis, and thrombosis.