Journal ArticleDOI
Physiological and pathophysiological role of magnesium in the cardiovascular system: implications in hypertension.
Pascal Laurant,Rhian M. Touyz +1 more
TLDR
The present review discusses the molecular, biochemical, physiological and pharmacological roles of magnesium in the regulation of vascular function and blood pressure and introduces novel concepts relating to magnesium as a second messenger in intracellular signaling in cardiovascular cells.Abstract:
Attention is growing for a potential role of magnesium in the pathoetiology of cardiovascular disease. Magnesium modulates mechanical, electrical and structural functions of cardiac and vascular cells, and small changes in extracellular magnesium levels and/or intracellular free magnesium concentration may have significant effects on cardiac excitability and on vascular tone, contractility and reactivity. Thus, magnesium may be important in the physiological regulation of blood pressure whereas alterations in cellular magnesium metabolism could contribute to the pathogenesis of blood pressure elevation. Although most epidemiological and experimental studies support a pathological role for magnesium in the etiology and development of hypertension, data from clinical studies have been less convincing. Furthermore, the therapeutic value of magnesium in the management of essential hypertension is unclear. The present review discusses the molecular, biochemical, physiological and pharmacological roles of magnesium in the regulation of vascular function and blood pressure and introduces novel concepts relating to magnesium as a second messenger in intracellular signaling in cardiovascular cells. In addition, alterations in magnesium regulation in experimental and clinical hypertension and the potential antihypertensive therapeutic effects of magnesium are addressed.read more
Citations
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Journal ArticleDOI
Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle
TL;DR: For the first time, results indicate that multiple functional TRPM and TRPV channels are coexpressed in rat intralobar PAs and aorta and may play important roles in the regulation of pulmonary and systemic circulation.
Journal ArticleDOI
Magnesium deficiency in critical illness.
Garrison M. Tong,Robert K. Rude +1 more
TL;DR: Magnesium therapy is not supported in the treatment of acute myocardial infarction and is presently undergoing evaluation for thetreatment of severe asthma exacerbation, for the prevention of postcoronary bypass grafting dysrhythmias, and as a neuroprotective agent in acute cerebral ischemia.
Journal ArticleDOI
Potassium, Magnesium, and Calcium: Their Role in Both the Cause and Treatment of Hypertension
Mark C. Houston,Karen J. Harper +1 more
TL;DR: The roles of potassium, magnesium, and calcium in the prevention and treatment of essential hypertension with specific emphasis on clinical trial evidence, mechanism of action, and recommendations for dietary intake of these minerals are discussed.
Journal ArticleDOI
Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension.
Mark C. Houston,Mark C. Houston +1 more
TL;DR: The expanded scientific roles for nutraceutical supplements will be discussed in relation to the prevention and treatment of essential hypertension with emphasis on mechanisms of action and clinical integration with drug therapy as indicated based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
Journal ArticleDOI
Role of magnesium in hypertension
Bruno Sontia,Rhian M. Touyz +1 more
TL;DR: The role of magnesium in the regulation of vascular function and blood pressure is addressed, the implications of magnesium deficiency in experimental and clinical hypertension, in metabolic syndrome and in pre-eclampsia are discussed and the therapeutic value is unclear.
References
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Journal Article
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Journal ArticleDOI
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Lawrence J. Appel,Thomas Burton Moore,Thomas Burton Moore,Eva Obarzanek,William M. Vollmer,Laura P. Svetkey,Frank M. Sacks,George A. Bray,Thomas M. Vogt,Jeffrey A. Cutler,Marlene M. Windhauser,Pao-Hwa Lin,Njeri Karanja,Denise G. Simons-Morton,Marjorie L. McCullough,Janis F. Swain,Priscilla Steele,Marguerite Evans,Edgar R. Miller,David W. Harsha +19 more
TL;DR: In this paper, the effects of dietary patterns on blood pressure were assessed in a clinical trial, Dietary Approaches to Stop Hypertension, where the subjects were fed a control diet that was low in fruits, vegetables, and dairy products, with a fat content typical of the average diet in the United States.
Journal ArticleDOI
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
TL;DR: Vascular NAD(P)H oxidases have been found to be essential in the physiological response of vascular cells, including growth, migration, and modification of the extracellular matrix and have been linked to hypertension and to pathological states associated with uncontrolled growth and inflammation, such as atherosclerosis.
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