Book ChapterDOI
Phytomedicine-Loaded Polymeric Nanomedicines: Potential Cancer Therapeutics
S. Maya,M. Sabitha,Shantikumar V. Nair,Rangasamy Jayakumar +3 more
- pp 203-239
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TLDR
This review focuses on the development of phytochemical-loaded polymeric nanoparticles and their application as potential anticancer therapeutic agents.Abstract:
Cancer continues to be one of the leading causes of death worldwide. Repeated treatment with chemotherapeutics has resulted in tumors that are resistant to these agents. So, it is becoming necessary to identify natural products that target multiple signaling pathways and cause growth inhibitory effects on human cancer cells without resulting in toxicity issues in normal cells. Curcumin, epigallocatechingallate (EGCG; green tea extract), resveratrol, saponins, silymarin, and grape seed extract (GSE) are some of the phytochemicals with significant anticancer potential that we will be focusing on in this review. Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. EGCG and GSE are two popular plant extracts that have attracted much attention in recent years due to their antioxidant, antimicrobial, anticarcinogenic, and anti-inflammatory properties. Saponins are a group of naturally occurring plant glycosides, of which at least 150 kinds of natural saponins have been found to possess significant anticancer properties. Silymarin, a mixture of mainly three flavonolignans (silybin, silychristin and silydianin), is extracted from the milk thistle and possesses potential biological properties. Even though these agents are potent anticancer agents, they are limited by their solubility, hydrophobicity, and low bioavailability. Polymeric nanocarriers provide an efficient platform for overcoming the factors that limit application of phytochemicals as therapeutic agents. This review focuses on the development of phytochemical-loaded polymeric nanoparticles and their application as potential anticancer therapeutic agents.read more
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Journal Article
Tea polyphenols: prevention of cancer and optimizing health. Discussion 4.
TL;DR: In this article, the authors examined the safety and possible efficacy of consuming the equivalent of > or =10 cups (> or =2.4 L) of green tea per day.
Journal ArticleDOI
Synthesis and characterization of curcumin loaded polymer/lipid based nanoparticles and evaluation of their antitumor effects on MCF-7 cells.
TL;DR: A novel polymer lipid based nanocarrier delivery system loaded with curcumin was demonstrated as an effective and potential alternative method for tumor treatment in MCF-7 cell line and it indicates that C-PSA-NPs are a suitable carrier forCurcumin.
Book ChapterDOI
Food colour additives of natural origin
TL;DR: In this chapter, a fairly compressed overview of the most important colours of natural origin as well as information about less common or/and promising colouring molecules are provided.
Journal ArticleDOI
Biocompatible Lipid Nanoparticles as Carriers to Improve Curcumin Efficacy in Ovarian Cancer Treatment
Maria Luisa Bondì,Maria Rita Emma,Chiara Botto,Giuseppa Augello,Antonina Azzolina,Francesca Di Gaudio,Emanuela Fabiola Craparo,Gennara Cavallaro,Dimcho Bachvarov,Melchiorre Cervello +9 more
TL;DR: The obtained results clearly suggest that the entrapment of curcumin into NLCs increasesCurcumin efficacy in vitro, indicating the potential use of N LCs as curcuming delivery systems.
Journal ArticleDOI
GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves.
Rawan Al-Nemari,Abdulrahman M. Al-Senaidy,Abdelhabib Semlali,Mohammad A. Ismael,Ahmed Yacine Badjah-Hadj-Ahmed,Abir Ben Bacha,Abir Ben Bacha +6 more
TL;DR: A. squamosa leaves contain major bioactive compounds that inhibit the growth of several types of bacteria and colon cancer cell lines, which demonstrated their efficacy as an alternative source of antibiotics and for the development of novel drugs for colon cancer therapy.
References
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Journal ArticleDOI
Polyphenols: food sources and bioavailability
TL;DR: The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
Journal ArticleDOI
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
TL;DR: A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption.
Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.