Journal ArticleDOI
Phytotherapy for treatment of cytokine storm in COVID-19.
Leena Sapra,Asha Bhardwaj,Zaffar Azam,Deekhsha Madhry,Bhupendra Verma,Sumit Rathore,Rupesh K. Srivastava +6 more
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TLDR
Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2.Abstract:
In 2020, a novel strain of coronavirus (COVID-19) has led to a significant morbidity and mortality worldwide As of the date of this writing, a total of 116 M cases has been diagnosed worldwide leading to 25 M deaths The number of mortalities is directly correlated with the rise of innate immune cells (especially macrophages) in the lungs that secrete inflammatory cytokines (IL-1β and IL-6) leading to the development of "Cytokine Storm Syndrome" (CSS), multi-organ-failure and death Given that currently the treatment of this condition is rare and release of effective vaccine might be months away, here, we review the plants and their pharmacologically active-compounds as potential phytopharmaceuticals for the virus induced inflammatory response Experimental validation of the effectiveness of these natural compounds to prevent or reduce the cytokine storm might be beneficial as an adjunct treatment of SARS-CoV-2read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal Article
The Hidden Mechanism beyond Ginger (Zingiber officinale Rosc.) Potent in vivo and in vitro Anti-Inflammatory Activity
Shahira M. Ezzat,Marwa I. Ezzat,Mona M. Okba,Esther T. Menze,Ashraf B. Abdel-Naim,Shahnas O. Mohamed +5 more
TL;DR: Ginger anti-inflammatory activity is mediated by inhibiting macrophage and neutrophils activation as well as negatively affecting monocyte and leukocyte migration, evidenced by the dose-dependent decrease in pro-inflammatory cytokines and chemokines and replenishment the total antioxidant capacity.
Journal Article
A bioinformatic approach to identify core genome difference between Salmonella Pullorum and Salmonella Enteritidis In silico screening of natural compounds against COVID-19 by targeting Mpro and ACE2 using molecular docking
Xiao Fei,Qiuchun Li,John Elmerdahl Olsen,Xinan Jiao,Tushar Joshi,Priyanka Sharma,Shalini Mathpal,Hemlata Pundir,Vikas Bhatt,Subhash Chandra +9 more
TL;DR: In this article, an automated bioinformatics workflow was developed and applied to identify core-genome differences between these two serovars with the aim to identify genome features associated with host specificity of S Pullorum.
Journal ArticleDOI
Can Panax ginseng help control cytokine storm in COVID-19?
TL;DR: Panax ginseng, a medicinal plant widely used for treating various conditions, might be appropriate for this need due to its anti-inflammatory/cytokine/viral activities, fewer side effects, and cost efficiency as mentioned in this paper .
Journal ArticleDOI
The Efficacy of Traditional Medicinal Plants in Modulating the Main Protease of SARS‐CoV‐2 and Cytokine Storm
TL;DR: Among these phytochemicals, glycyrrhizin, withaferin A, curcumin, nigellidine and cordifolioside A suppressed SARS‐CoV‐2 replication and showed stronger anti‐inflammatory activities than standard Covid‐19 drugs.
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Journal ArticleDOI
Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation
Venkatesh Pooladanda,Sowjanya Thatikonda,Swarna Bale,Bijay Pattnaik,Dilep Kumar Sigalapalli,Nagendra Babu Bathini,Shashi Bala Singh,Chandraiah Godugu +7 more
TL;DR: Results indicate that TNF-α-regulated NF-κB and HDAC-3 crosstalk was ameliorated by nimbolide with promising anti-nitrosative, antioxidant, and anti-inflammatory properties in LPS-induced ARDS.
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Evaluation of antiviral activity of Ocimum sanctum and Acacia arabica leaves extracts against H9N2 virus using embryonated chicken egg model.
S. S. Ghoke,Richa Sood,Naveen Kumar,A. K. Pateriya,Sandeep Bhatia,Alka Mishra,Ritu B. Dixit,Vikas Singh,Dhruv Desai,Diwakar D. Kulkarni,Umesh Dimri,Vijendra Pal Singh +11 more
TL;DR: The crude extract and terpenoid isolated from the leaves of O. sanctum and polyphenol from A. arabica has shown promising antiviral properties against H9N2 virus.
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Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.
TL;DR: Findings present an alternative to antibiotic misuse for upper respiratory symptoms due to viral infections, and a potentially safer alternative to prescription drugs for routine cases of the common cold and influenza.
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Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium-Induced Colitis Mice
TL;DR: The treatment of seven types of tea could alleviate DSS-induced colitis in mice, and modulate the dysbiosis of gut microbiota in colitis mice.
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Use of herbal drugs to treat COVID-19 should be with caution.
TL;DR: Driven by the claim that some patent herbal drugs can effectively treat COVID-19, some patients with flu symptoms are likely to selfmedicate with herbal remedies and avoid going to hospital, thus delaying the proper diagnosis and treatment of the disease, and hampering the government’s testing, tracing, and quarantining efforts.