Journal ArticleDOI
Pitavastatin-induced downregulation of CCR2 and CCR5 in monocytes is associated with the arrest of cell-cycle in S phase
Masahiro Fujino,Shin-ichiro Miura,Yoshino Matsuo,Hiroaki Tanigawa,Akira Kawamura,Keijiro Saku +5 more
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TLDR
The anti-proliferative effect of pitavastatin but not pravastatin, through the downregulation of CCR2/CCR5 may be a pleiotropic effect that may be anti-atherogenic in monocytes.About:
This article is published in Atherosclerosis.The article was published on 2006-08-01. It has received 16 citations till now. The article focuses on the topics: Pitavastatin & CCL2.read more
Citations
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Pleiotropic effects of statins
James K. Liao,Ulrich Laufs +1 more
TL;DR: Recent studies indicate that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response.
Journal ArticleDOI
Pleiotropic effects of statins. - Basic research and clinical perspectives -.
Qian Zhou,James K. Liao +1 more
TL;DR: The aim of the present review is to provide an update on the non-cholesterol-dependent statin effects in the cardiovascular system and highlight some of the recent findings from bench to bedside to support the concept of statin pleiotropy.
Journal ArticleDOI
Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma
Fabienne Guillaumond,Ghislain Bidaut,Mehdi Ouaissi,Stéphane Servais,Victoire Gouirand,Orianne Olivares,Sophie Lac,Laurence Borge,Julie Roques,Odile Gayet,Michelle Pinault,Cyrille Guimaraes,Jérémy Nigri,Celine Loncle,Marie-Noëlle Lavaut,Stéphane Garcia,Anne Tailleux,Bart Staels,Ezequiel Calvo,Richard Tomasini,Juan L. Iovanna,Sophie Vasseur +21 more
TL;DR: E elucidation of the metabolic signature of PDAC has identified the low-density lipoprotein receptor (LDLR), which facilitates cholesterol uptake, as a promising therapeutic target, and identifies LDLR as a novel metabolic target to limit PDAC progression and disease patient relapse.
Journal ArticleDOI
Pleiotropic effects of pitavastatin
TL;DR: It is concluded that the diverse pleiotropic actions of pitavastatin may contribute to reducing cardiovascular morbidity and mortality beyond that achieved through LDL-C reduction.
Journal ArticleDOI
Involvement of Chk1-Cdc25A-cyclin A/CDK2 pathway in simvastatin induced S-phase cell cycle arrest and apoptosis in multiple myeloma cells.
TL;DR: Results suggested that the Chk1-Cdc25A-cyclin A/CDk2 pathway was involved in simvastatin-induced S-phase cell cycle arrest and apoptosis in multiple myeloma cell lines.
References
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
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The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
Frank M. Sacks,Marc A. Pfeffer,Lemuel A. Moyé,Jean L. Rouleau,John D. Rutherford,Thomas G. Cole,Lisa E. Brown,J. W. Warnica,J. M. O. Arnold,Chuan Chuan C Wun,Barry R. Davis,Eugene Braunwald +11 more
TL;DR: It is demonstrated that the benefit of cholesterol-lowering therapy extends to the majority of patients with coronary disease who have average cholesterol levels and was also greater in patients with higher pretreatment levels of LDL cholesterol.
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Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Journal ArticleDOI
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.