Platelet dysfunction during trauma involves diverse signaling pathways and an inhibitory activity in patient-derived plasma.
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Platelet dysfunction in trauma patients included poor response to multiple agonists relevant to hemostatic function, which suggests that soluble plasma species may downregulate endogenous or transfused platelets during trauma.Abstract:
BACKGROUNDTrauma-induced coagulopathy occurs in about 25% of injured patients and accounts for about 10% of deaths worldwide. Upon injury, hemostatic function may decline due to vascular dysfunction, clotting factor deficiencies, hyperfibrinolysis, and/or platelet dysfunction. We investigated agonisread more
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Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage
Paul Vulliamy,Scarlett Gillespie,Paul C Armstrong,Harriet E. Allan,Timothy D. Warner,Karim Brohi +5 more
TL;DR: The presence of ballooning procoagulant platelets free in the circulation of critically injured humans is demonstrated, a phenomenon which results in systemic generation of thrombin and contributes to an acute coagulopathy.
Journal ArticleDOI
Alterations in platelet behavior after major trauma: adaptive or maladaptive?
Paul Vulliamy,Lucy Z. Kornblith,Matthew E. Kutcher,Mitchell J. Cohen,Karim Brohi,Matthew D. Neal +5 more
TL;DR: Current understanding of adaptive and maladaptive alterations in platelet biology induced by severe trauma, mechanisms underlying these alterations, potential platelet-focused therapies, and existing knowledge gaps and their research implications are detailed.
Journal ArticleDOI
Time Course of Hemostatic Disruptions After Traumatic Brain Injury: A Systematic Review of the Literature
Alexander Fletcher-Sandersjöö,Alexander Fletcher-Sandersjöö,Eric Peter Thelin,Eric Peter Thelin,Marc Maegele,Mikael Svensson,Mikael Svensson,Bo-Michael Bellander,Bo-Michael Bellander +8 more
TL;DR: It is found that the first hours after TBI are characterized by coagulation cascade dysfunction and hyperfibrinolysis, both of which likely contribute to lesion progression, and this is then followed by platelet dysfunction and decreased platelet count, the clinical implication of which remains unclear.
Journal ArticleDOI
The effect of platelet transfusion in patients with traumatic brain injury and concomitant antiplatelet use: a systematic review and meta-analysis
TL;DR: The impact of platelet transfusion on mortality in patients with TBI and preinjury antiplatelet therapy compared to control TBI cases is investigated to clarify whether there is a reasonable indication for providing this costly, supply-limited, and potentially harmful treatment.
References
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Journal ArticleDOI
The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care
TL;DR: Results of this investigation indicate that the Injury Severity Score represents an important step in solving the problem of summarizing injury severity, especially in patients with multiple trauma.
Journal ArticleDOI
Transfusion of plasma, platelets, and red blood cells in a 1: 1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial
John B. Holcomb,Barbara C. Tilley,Sarah Baraniuk,Erin E. Fox,Charles E. Wade,Jeanette M. Podbielski,Deborah J. del Junco,Karen J. Brasel,Karen J. Brasel,Eileen M. Bulger,Rachael A. Callcut,Mitchell J. Cohen,Bryan A. Cotton,Timothy C. Fabian,Kenji Inaba,Jeffrey D. Kerby,Peter Muskat,Peter Muskat,Terence O'Keeffe,Sandro Rizoli,Bryce R.H. Robinson,Thomas M. Scalea,Martin A. Schreiber,Deborah M. Stein,Jordan A. Weinberg,Jeannie Callum,John R. Hess,Nena Matijevic,Christopher N. Miller,Jean-Francois Pittet,David B. Hoyt,Gail D. Pearson,Brian G. Leroux,Gerald van Belle +33 more
TL;DR: In this article, the effectiveness and safety of transfusing patients with severe trauma and major bleeding using plasma, platelets, and red blood cells in a 1:1:1 ratio compared with a 1 :1:2 ratio was evaluated.
Journal ArticleDOI
Acute traumatic coagulopathy.
TL;DR: There is a common and clinically important acute traumatic coagulopathy that is not related to fluid administration that is related to mortality and a coagulation screen is an important early test in severely injured patients.
Journal ArticleDOI
The coagulopathy of trauma: a review of mechanisms.
John R. Hess,Karim Brohi,Richard P. Dutton,Carl J. Hauser,John B. Holcomb,Yoram Kluger,Kevin Mackway-Jones,Michael Parr,Sandro Rizoli,Tetsuo Yukioka,David B. Hoyt,Bertil Bouillon +11 more
TL;DR: There is limited understanding of the mechanisms by which tissue trauma, shock, and inflammation initiate trauma coagulopathy, and Acute Coagulopathic of Trauma-Shock should be considered distinct from disseminated intravascular coagulation as described in other conditions.
Journal ArticleDOI
Characterization of platelet dysfunction after trauma.
Matthew E. Kutcher,Brittney J. Redick,Ryan C. McCreery,Ian M. Crane,Molly D. Greenberg,Leslie M. Cachola,Mary F. Nelson,Mitchell J. Cohen +7 more
TL;DR: Clinical significant platelet dysfunction after trauma is identified in the presence of an otherwise reassuring platelet count and standard clotting studies, with profound implications for mortality.
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Transfusion of plasma, platelets, and red blood cells in a 1: 1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial
John B. Holcomb,Barbara C. Tilley,Sarah Baraniuk,Erin E. Fox,Charles E. Wade,Jeanette M. Podbielski,Deborah J. del Junco,Karen J. Brasel,Karen J. Brasel,Eileen M. Bulger,Rachael A. Callcut,Mitchell J. Cohen,Bryan A. Cotton,Timothy C. Fabian,Kenji Inaba,Jeffrey D. Kerby,Peter Muskat,Peter Muskat,Terence O'Keeffe,Sandro Rizoli,Bryce R.H. Robinson,Thomas M. Scalea,Martin A. Schreiber,Deborah M. Stein,Jordan A. Weinberg,Jeannie Callum,John R. Hess,Nena Matijevic,Christopher N. Miller,Jean-Francois Pittet,David B. Hoyt,Gail D. Pearson,Brian G. Leroux,Gerald van Belle +33 more