Journal ArticleDOI
Poloxamine-based nanomaterials for drug delivery.
Carmen Alvarez-Lorenzo,Ana Rey-Rico,Alejandro Sosnik,Pablo Taboada,Angel Concheiro,Angel Concheiro +5 more
TLDR
The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles.Abstract:
Poloxamines (Tetronic) are X-shaped amphiphilic block copolymers formed by four arms of poly(ethylene oxide)-poly(propylene oxide) (PEO-PPO) blocks bonded to a central ethylenediamine moiety Such a structure confers multi-responsive behaviour, namely temperature and pH-sensitiveness At relatively low concentrations but above the critical micellar concentration (CMC), poloxamines generate polymeric micelles Due to the presence of a hydrophobic core, these nanocarriers are useful in the solubilization and stabilization of poorly water-soluble drugs Moreover, chemical modification of the micellar core is feasible These remarkable and unique features, compared to the well-known linear poloxamers, have motivated an increasing interest in the study and application of the branched derivatives in different emerging disciplines The present review concisely overviews the most important developments comprising the application of poloxamines in drug delivery, mainly as micellar carriers capable of enhancing drug solubility and stability, and also as surface modifiers in the technology of stealth polymeric nanoparticles Their potential for the administration of drugs by different routes and the improvement of the drug bioavailability and therapeutic effect are discussedread more
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Customizing poly(lactic-co-glycolic acid) particles for biomedical applications
TL;DR: The range of formulation techniques, manipulations, and applications of poly(lactic-co-glycolic acid) (PLGA) particles are discussed to enable researchers to effectively select or design the optimal particles for their application.
Journal ArticleDOI
Nanoparticles and cancer therapy: Perspectives for application of nanoparticles in the treatment of cancers.
Ali Aghebati-Maleki,Sanam Dolati,Majid Ahmadi,Amir Baghbanzhadeh,Milad Asadi,Ali Fotouhi,Mehdi Yousefi,Leili Aghebati-Maleki +7 more
TL;DR: The role of NPs in treating cancer among different drug delivery methods for cancer therapy is discussed and a wide range of nanomaterials based on organic, inorganic, lipid, or glycan compounds, as well as on synthetic polymers has been utilized for the development of new cancer therapeutics.
Journal ArticleDOI
Poloxamer Hydrogels for Biomedical Applications
Eleonora Russo,Carla Villa +1 more
TL;DR: The use of poloxamers as biosurfactants is evaluated since they are able to form micelles in an aqueous environment above a concentration threshold known as critical micelle concentration (CMC), which is exploited for drug delivery and different therapeutic applications.
Journal ArticleDOI
Development of stimuli-responsive nano-based pesticides: emerging opportunities for agriculture
Marcela Candido Camara,EstefAcentsnia Vangelie Ramos Campos,EstefAcentsnia Vangelie Ramos Campos,Renata Aparecida Monteiro,Anderson do Espirito Santo Pereira,Patrícia L. F. Proença,Leonardo Fernandes Fraceto +6 more
TL;DR: The current status of stimuli-responsive release systems with potential to be used in agriculture are discussed, highlighting the challenges and drawbacks that need to be overcome in order to accelerate the global commercialization of smart nanopesticides.
Journal ArticleDOI
Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability.
TL;DR: The stabilizing effect, role of stabilizers in final nanocrystalline formulations, challenges in reaching in vitro–in vivo correlation with nanocrystaline products, and stabilizers’ effect on higher bioavailability are discussed.
References
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Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.
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Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
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Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association
TL;DR: In this article, a closed association model was used to describe the copolymer micellization process for the majority of the Pluronics and used to obtain the standard free energies, enthalpies, and entropies of micellisation.
Journal ArticleDOI
Micellar nanocarriers: pharmaceutical perspectives.
TL;DR: This review will discuss some recent trends in using micelles as pharmaceutical carriers, including lipid-core micells, which may become the imaging agents of choice in different imaging modalities.