Journal ArticleDOI
Polymeric micelles coated with hybrid nanovesicles enhance the therapeutic potential of the reversible topoisomerase inhibitor camptothecin in a mouse model.
TLDR
A hybrid system to encapsulate CPT inside the amphiphilic micelle and coat it with RBC membrane is developed, which resulted in the increased overall survival of mice treated with the nano formulation and showed strong retention inside the Ehrlich Ascites Carcinoma mice models for at least 72 h, suggesting camouflaging ability conferred by RBC membranes.About:
This article is published in Acta Biomaterialia.The article was published on 2021-02-01. It has received 26 citations till now. The article focuses on the topics: Camptothecin.read more
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A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives.
TL;DR: In this article, the authors reviewed the latest advances of LAPFs in preclinical and clinical stages, focusing on the strategies and underlying mechanisms for achieving long acting, and classified existing strategies into manipulation of in vivo clearance and manipulation of drug release from delivery systems, respectively.
Journal ArticleDOI
Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review
TL;DR: In this paper, a comprehensive and critical evaluation of the anticancer ability of nano-CPT in various cancers as a novel and more efficient natural compound for drug development is provided.
Journal ArticleDOI
Red blood cells membrane-derived nanoparticles: Applications and key challenges in their clinical translation.
TL;DR: This review gives the critical analysis of barriers involved in the translation of RBCs-derived nanoparticles from preclinical to clinical level and highlights the biomedical applications of such vesicles.
Journal ArticleDOI
Aptamer-Enabled Nanomaterials for Therapeutics, Drug Targeting and Imaging
TL;DR: Recent progress in aptamer-enabled materials is reviewed and pending challenges for their future biomedical application are discussed.
Journal ArticleDOI
Expanding the arsenal against pulmonary diseases using surface-functionalized polymeric micelles: breakthroughs and bottlenecks.
Rubiya Khursheed,Keshav Raj Paudel,Monica Gulati,Sukriti Vishwas,Niraj K. Jha,Philip M. Hansbro,Brian G. Oliver,Kamal Dua,Sachin Kumar Singh +8 more
TL;DR: In the current review, emphasis has been placed on the different barriers encountered by the drugs given via the pulmonary route and the mechanism of PMs in achieving drug targeting.
References
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Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
TL;DR: These factors have been shown to substantially affect the biodistribution and blood circulation half-life of circulating nanoparticles by reducing the level of nonspecific uptake, delaying opsonization, and increasing the extent of tissue specific accumulation.
Journal Article
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
TL;DR: In this article, the authors discuss the factors which can influence nanoparticle blood residence time and organ specific accumulation, including interactions with biological barriers and tunable nanoparticle parameters, such as composition, size, core properties, surface modifications (pegylation and surface charge), and targeting ligand functionalization.
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Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
TL;DR: This work used Drosophila melanogaster larvae to develop a high-throughput whole organism screen for drugs that modulate food intake and identified the serotonin (5-hydroxytryptamine or 5-HT) receptor antagonist metitepine as a potent anorectic drug.
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Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
TL;DR: A thorough discussion of the physiologic aspects of nanoparticle clearance, focusing on renal mechanisms, is presented and an overview of current research investigating clearance of specific types of nanoparticles and nano-sized macromolecules is provided.