Journal ArticleDOI
Popping the cork: mechanisms of phage genome ejection
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TLDR
The structure of the DNA inside mature phages is described and the current models of genome ejection, both in vitro and in vivo, are summarized.Abstract:
Sixty years after Hershey and Chase showed that nucleic acid is the major component of phage particles that is ejected into cells, we still do not fully understand how the process occurs. Advances in electron microscopy have revealed the structure of the condensed DNA confined in a phage capsid, and the mechanisms and energetics of packaging a phage genome are beginning to be better understood. Condensing DNA subjects it to high osmotic pressure, which has been suggested to provide the driving force for its ejection during infection. However, forces internal to a phage capsid cannot, alone, cause complete genome ejection into cells. Here, we describe the structure of the DNA inside mature phages and summarize the current models of genome ejection, both in vitro and in vivo.read more
Citations
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Bacteria–phage coevolution as a driver of ecological and evolutionary processes in microbial communities
TL;DR: This review sums up the current understanding of bacteria–phage coevolution both in the laboratory and in nature, and discusses recent findings on both thecoevolutionary process itself and the impact of coev evolution on bacterial phenotype, diversity and interactions with other species (particularly their eukaryotic hosts).
Journal ArticleDOI
Host receptors for bacteriophage adsorption
TL;DR: An open-access resource, the Phage Receptor Database (PhReD), is established to serve as a repository for information on known and newly identified phage receptors involved in recognition and adsorption and their interactions during attachment.
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Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective
TL;DR: This work reviews not only the structural design and stochastic kinetics of individual single motors, but also their coordination, cooperation and competition as well as the assembly of multi-module motors in various intracellular kinetic processes.
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Bacteriophage lambda: Early pioneer and still relevant.
TL;DR: This review gives some relevant early history of phage lambda, describes recent developments in understanding the molecular biology of lambda's life cycle and describes the molecular nature of lysogeny.
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Polymer translocation: the first two decades and the recent diversification
TL;DR: It is argued that the phenomenon of polymer translocation is non-universal and highly sensitive to the exact specifications of the models and experiments used towards its analysis, and where the field is going.
References
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Book
Principles of Nucleic Acid Structure
TL;DR: The goal of this series is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields.
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Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III
TL;DR: A reprint of Avery, MacLeod, and McCarty's article on the 35th anniversary of its original publication.
Journal ArticleDOI
Marine viruses — major players in the global ecosystem
TL;DR: Viruses are by far the most abundant 'lifeforms' in the oceans and are the reservoir of most of the genetic diversity in the sea, thereby driving the evolution of both host and viral assemblages.
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Bacteriophage resistance mechanisms.
TL;DR: This Review highlights the most important antiviral mechanisms of bacteria as well as the counter-attacks used by phages to evade these systems.
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Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage.
Alfred Day Hershey,Martha Chase +1 more
TL;DR: All types of evidence show that the passage of phage DNA into the cell occurs in non-nutrient medium under conditions in which other known steps in viral growth do not occur.