Postnatal Remodeling of Gonadotropin-Releasing Hormone I Neurons: Toward Understanding the Mechanism of the Onset of Puberty
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This article is published in Endocrinology.The article was published on 2006-08-01 and is currently open access. It has received 11 citations till now. The article focuses on the topics: Gonadotropin-releasing hormone & Hypothalamus.read more
Citations
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Journal ArticleDOI
Association weight matrix for the genetic dissection of puberty in beef cattle.
Marina R. S. Fortes,Antonio Reverter,Yuandan Zhang,E. Collis,Shivashankar H. Nagaraj,Nicholas N. Jonsson,K. C. Prayaga,Wes Barris,Rachel Hawken +8 more
TL;DR: In this article, a system biology approach for the genetic dissection of complex traits based on applying gene network theory to the results from genome-wide associations was described, and an association weight matrix (AWM) was constructed with as many rows as genes and as many columns as traits.
Journal ArticleDOI
The genetic basis for the timing of human puberty.
TL;DR: The development of pulsatile release of GnRH secretion mediated through kisspeptin‐1 activation of G‐protein coupled receptor‐54 appears to be a central event at the onset and during progression of puberty.
Journal ArticleDOI
Birth characteristics and age at menarche: results from the dietary intervention study in children (DISC)
TL;DR: Higher birth weight may be associated with a modest delay in age at menarche, and no statistically significant relationships were detected between either length or gestational age and age atMenarche.
Book ChapterDOI
Puberty in the Female and Its Disorders
TL;DR: This chapter begins with a basic science update on the development of the female reproductive system and concludes with a review of the maturation of sex hormone target organs covering both the classical and nonclassical effects of sex steroids on their targets.
References
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Journal ArticleDOI
Dynamic mapping of human cortical development during childhood through early adulthood
Nitin Gogtay,Jay N. Giedd,Leslie Lusk,Kiralee M. Hayashi,Deanna Greenstein,A. Catherine Vaituzis,Tom F. Nugent,David H. Herman,Liv S. Clasen,Arthur W. Toga,Judith L. Rapoport,Paul M. Thompson +11 more
TL;DR: The dynamic anatomical sequence of human cortical gray matter development between the age of 4-21 years using quantitative four-dimensional maps and time-lapse sequences reveals that higher-order association cortices mature only after lower-order somatosensory and visual cortices are developed.
Journal ArticleDOI
Regional differences in synaptogenesis in human cerebral cortex.
TL;DR: Findings in the human resemble those in rhesus monkeys, including overproduction of synaptic contacts in infancy, persistence of high levels of synaptic density to late childhood or adolescence, the absolute values of maximum and adult synaptic density, and layer specific differences.
Journal ArticleDOI
Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density.
TL;DR: Estradiol treatment increases sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input; further, sensitivity to NMda receptor- mediated synaptic input is well correlated with dendritic spine density.
Journal ArticleDOI
Neurobiological mechanisms of the onset of puberty in primates.
Ei Terasawa,David L. Fernandez +1 more
TL;DR: Developmental changes in several neurotransmitter systems controlling pulsatile LHRH release are extensively reviewed and it appears that the reduction in tonic GABA inhibition allows an increase in the release of glutamate as well as other neurotransmitters, which contributes to the increase in pubertal L HRH release.
Journal ArticleDOI
Gonadotropin-releasing hormone and its analogs
Conn Pm,William F. Crowley +1 more
TL;DR: The physiologic and pharmacologic principles underlying the advances produced by these agents, the mechanism of action of GnRH and its analogues at the cellular level, and the individual therapeutic applications to which these analogues have been applied are examined.
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