Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.
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TLDR
An overview on microRNAs that are involved in the Aβ cascade and their inhibitory impact on their target mRNAs whose products participate in Aβ clearance is discussed.Citations
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CRISPR-Cas12a (Cpf1): A Versatile Tool in the Plant Genome Editing Tool Box for Agricultural Advancement.
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miR-34a in Neurophysiology and Neuropathology.
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MicroRNA-7: expression and function in brain physiological and pathological processes
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Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression
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References
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Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood–cerebrospinal fluid barrier in human brain
TL;DR: These findings may suggest that these multiple transporters/receptors and IDE expressed on the choroid plexus epithelium, ventricular ependymal cells and brain microvessels complementarily or cooperatively contribute to the clearance of amyloid-β peptides from the brain.
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Involvement of miR-485-5p in hepatocellular carcinoma progression targeting EMMPRIN.
TL;DR: This study demonstrated that miR-485-5p represses HCC invasive and metastatic capacities by targeting EMMPRIN expression and suppressed HCC growth in vivo by down-regulation of EMM PRIN.
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An epigenetic regulatory loop controls pro-osteogenic activation by TGF-β1 or bone morphogenetic protein 2 in human aortic valve interstitial cells.
TL;DR: The miR-486-Smurf2-Smad loop plays an important role in regulating AVIC pro-osteogenic activation in response to TGF-β1 or BMP-2, and targeting this regulatory loop may have therapeutic potential for suppressing aortic valve calcification.
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MicroRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma.
Changli Zheng,Jingjing Li,Qi Wang,Wei Liu,Jianda Zhou,Rui Liu,Qinghai Zeng,Xiaowei Peng,Chenghui Huang,Peiguo Cao,Ke Cao +10 more
TL;DR: It is demonstrated that miR-195 acts as a tumor suppressor by directly targeting CBX4 in HCC and suggests a potential novel strategy for therapeutic interventions of this disease.