Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.
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TLDR
An overview on microRNAs that are involved in the Aβ cascade and their inhibitory impact on their target mRNAs whose products participate in Aβ clearance is discussed.Citations
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CRISPR-Cas12a (Cpf1): A Versatile Tool in the Plant Genome Editing Tool Box for Agricultural Advancement.
Anindya Bandyopadhyay,Nagesh Kancharla,Vivek S. Javalkote,Santanu Dasgupta,Thomas P. Brutnell +4 more
TL;DR: A comparative survey of CRISPR-Cas12a and Cas9 is provided, and a perspective on applications of CRisPR- Cas12 in agriculture is provided.
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miR-34a in Neurophysiology and Neuropathology.
TL;DR: The known and emerging roles of the miR-34a regulatory network in neurophysiology and neuropathology are discussed and modulated by factors that control its expression as well as its downstream target genes and signaling pathways.
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Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis
Weiying Sun,Jun Zhao,Chunzhi Li +2 more
TL;DR: The findings showed that Dex administration resulted in the enhancement of miR-129 expression with declined hippocampal neuron apoptosis and attenuated cognitive impairment in Aβ1–42-injected mice, suggesting the miR -129/YAP1/JAG1 axis could potentially be the mechanism by which Dex protects AD mice from cognitive impairment.
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MicroRNA-7: expression and function in brain physiological and pathological processes
TL;DR: In-depth studies on the role of miR-7 in brain physiology and pathology undoubtedly not only provide a light on the roles of miRNAs in brain development and diseases, but also are much helpful for ultimate development of therapeutic strategies against brain diseases.
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Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression
Omayma A.R. AboZaid,M. W. Sallam,Sawsan M El-Sonbaty,Samy Ali Hussein Aziza,Basma Emad,Esraa S. A. Ahmed +5 more
TL;DR: N nano-formulation of resveratrol with selenium maximized the therapeutic potential of RSV against Alzheimer’s disease not only by their antioxidant but also by anti-inflammatory effect improving the neurocognitive function and modulating the signaling pathways.
References
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MicroRNA 302a Is a Novel Modulator of Cholesterol Homeostasis and Atherosclerosis
TL;DR: In this paper, the involvement of miR-302a in macrophage lipid homeostasis and if it can influence circulating lipid levels and atherosclerotic development when it is inhibited in a murine atherosclerosis model.
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Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas
TL;DR: It is suggested that the four miRNAs may exert protective phenotypes by targeting breast oncogenes that contribute to patient survival by targeting survival-associated genes RAD51, RRP1B, and TDG.
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Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection.
Tal Iram,Dorit Trudler,David Kain,Sivan Kanner,Ronit Galron,Robert Vassar,Ari Barzilai,Pablo Blinder,Zvi Fishelson,Dan Frenkel +9 more
TL;DR: Old 5xFAD astrocytes show impairment in support of neuronal growth in co-culture and neurotoxicity concomitant with an elevation in IL-6 expression, and that expression of scavenger receptor B1 is reduced in adult old 5xfad astroCytes.
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Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Chao Min Cheng,Chao Min Cheng,Shine-Gwo Shiah,Chien Chang Huang,Jenn Ren Hsiao,Jang Yang Chang,Jang Yang Chang +6 more
TL;DR: It is revealed that miR‐455‐5p expression is regulated by the TGF‐β‐dependent pathway, which subsequently leads to UBE2B down‐regulation and contributes to oral cancer tumourigenesis.
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miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways
Hui Wang,Tao Sun,Jing Hu,Rui Zhang,Yanhua Rao,Shuai Wang,Rui Chen,Roger E. McLendon,Allan H. Friedman,Stephen T. Keir,Darell D. Bigner,Qi-Jing Li,Huibo Wang,Xiao-Fan Wang +13 more
TL;DR: A miR-33a-centered signaling network that promotes GIC maintenance and has potential as a therapeutic target for GBM treatment is revealed.