Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.
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TLDR
An overview on microRNAs that are involved in the Aβ cascade and their inhibitory impact on their target mRNAs whose products participate in Aβ clearance is discussed.Citations
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CRISPR-Cas12a (Cpf1): A Versatile Tool in the Plant Genome Editing Tool Box for Agricultural Advancement.
Anindya Bandyopadhyay,Nagesh Kancharla,Vivek S. Javalkote,Santanu Dasgupta,Thomas P. Brutnell +4 more
TL;DR: A comparative survey of CRISPR-Cas12a and Cas9 is provided, and a perspective on applications of CRisPR- Cas12 in agriculture is provided.
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miR-34a in Neurophysiology and Neuropathology.
TL;DR: The known and emerging roles of the miR-34a regulatory network in neurophysiology and neuropathology are discussed and modulated by factors that control its expression as well as its downstream target genes and signaling pathways.
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Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis
Weiying Sun,Jun Zhao,Chunzhi Li +2 more
TL;DR: The findings showed that Dex administration resulted in the enhancement of miR-129 expression with declined hippocampal neuron apoptosis and attenuated cognitive impairment in Aβ1–42-injected mice, suggesting the miR -129/YAP1/JAG1 axis could potentially be the mechanism by which Dex protects AD mice from cognitive impairment.
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MicroRNA-7: expression and function in brain physiological and pathological processes
TL;DR: In-depth studies on the role of miR-7 in brain physiology and pathology undoubtedly not only provide a light on the roles of miRNAs in brain development and diseases, but also are much helpful for ultimate development of therapeutic strategies against brain diseases.
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Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression
Omayma A.R. AboZaid,M. W. Sallam,Sawsan M El-Sonbaty,Samy Ali Hussein Aziza,Basma Emad,Esraa S. A. Ahmed +5 more
TL;DR: N nano-formulation of resveratrol with selenium maximized the therapeutic potential of RSV against Alzheimer’s disease not only by their antioxidant but also by anti-inflammatory effect improving the neurocognitive function and modulating the signaling pathways.
References
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Journal ArticleDOI
The microRNA-1908 up-regulation in the peripheral blood cells impairs amyloid clearance by targeting ApoE.
Z. Wang,W. Qin,C.B. Wei,Y. Tang,L.N. Zhao,H.M. Jin,Yan Li,Q. Wang,Xiaoqian Luan,John Cijiang He,Jianping Jia +10 more
TL;DR: To give a new insight into the mechanism of ApoE dysregulation and microRNA‐1908 in Alzheimer's disease (AD), a new approach is presented that combines EMT and “ ‘cell reprograming’ techniques.
Journal Article
MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression.
TL;DR: It is suggested that miR-148a is a tumor suppressor, which could be a promising therapeutic target for breast cancer and exerts its anti-invasive functions through downregulation of USP4 and BIM.
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Deregulation of miR-34a and Its Chaperon Hsp70 in Hepatitis C virus-Induced Liver Cirrhosis and Hepatocellular Carcinoma Patients
Rasha H Shehata,Soha A Abdelmoneim,Ahmed Osman,Ahmed Hassanain,Amany Osama,Sahar S. Abdelmoneim,Eman A. Toraih +6 more
TL;DR: In this article, the authors evaluated serum expression of miR-34a and its target Hsp70 for early detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC), focusing on correlations with clinicopathological features.
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MicroRNA-463-3p/ABCG4: A new axis in glucose-stimulated insulin secretion.
TL;DR: Glucose‐stimulated insulin secretion (GSIS) is known to be essential in the control of metabolic fuel homeostasis, though the molecular mechanisms involved remain unclear.
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Downregulation of autophagy-related gene ATG5 and GABARAP expression by IFN-λ1 contributes to its anti-HCV activity in human hepatoma cells.
Xu Li,Yu Li,Shoucai Fang,Jinming Su,Junjun Jiang,Bingyu Liang,Jiegang Huang,Bo Zhou,Zang Ning,Wen-Zhe Ho,Jieliang Li,Yi-Ping Li,Hui Chen,Li Ye,Hao Liang +14 more
TL;DR: Results indicate that suppression of the autophagy response by IFN‐&lgr;1 contributes to IFN;1 anti‐HCV activity, and provides a theoretical basis for improving the effectiveness of IFN treatment of HCV infection through inhibition of the HCV‐induced autophile response.