Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.
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TLDR
An overview on microRNAs that are involved in the Aβ cascade and their inhibitory impact on their target mRNAs whose products participate in Aβ clearance is discussed.Citations
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CRISPR-Cas12a (Cpf1): A Versatile Tool in the Plant Genome Editing Tool Box for Agricultural Advancement.
Anindya Bandyopadhyay,Nagesh Kancharla,Vivek S. Javalkote,Santanu Dasgupta,Thomas P. Brutnell +4 more
TL;DR: A comparative survey of CRISPR-Cas12a and Cas9 is provided, and a perspective on applications of CRisPR- Cas12 in agriculture is provided.
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miR-34a in Neurophysiology and Neuropathology.
TL;DR: The known and emerging roles of the miR-34a regulatory network in neurophysiology and neuropathology are discussed and modulated by factors that control its expression as well as its downstream target genes and signaling pathways.
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Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis
Weiying Sun,Jun Zhao,Chunzhi Li +2 more
TL;DR: The findings showed that Dex administration resulted in the enhancement of miR-129 expression with declined hippocampal neuron apoptosis and attenuated cognitive impairment in Aβ1–42-injected mice, suggesting the miR -129/YAP1/JAG1 axis could potentially be the mechanism by which Dex protects AD mice from cognitive impairment.
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MicroRNA-7: expression and function in brain physiological and pathological processes
TL;DR: In-depth studies on the role of miR-7 in brain physiology and pathology undoubtedly not only provide a light on the roles of miRNAs in brain development and diseases, but also are much helpful for ultimate development of therapeutic strategies against brain diseases.
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Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression
Omayma A.R. AboZaid,M. W. Sallam,Sawsan M El-Sonbaty,Samy Ali Hussein Aziza,Basma Emad,Esraa S. A. Ahmed +5 more
TL;DR: N nano-formulation of resveratrol with selenium maximized the therapeutic potential of RSV against Alzheimer’s disease not only by their antioxidant but also by anti-inflammatory effect improving the neurocognitive function and modulating the signaling pathways.
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Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes.
TL;DR: The results suggest a new paradigm to explain the mechanisms underlying ITP, involving the regulation of megakaryocytopoiesis by viral microRNAs through the intronic hsa-microRNA.
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Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4: site-specific expression of mouse Abcg4 in brain.
Shoko Koshiba,Takehito Ito,Akira Shiota,Kanako Wakabayashi,Masatsugu Ueda,Hiroshi Ichinose,Toshihisa Ishikawa +6 more
TL;DR: Results suggest that mouse Abcg4 plays a certain physiological role in the brain, and the antibody raised against the epitope encoding the amino acids 46-60 was found to be specific to mouse Ab cg4, exhibiting a band with molecular weight of 63,000 on immunoblotting, whereas this band was dose-dependently diminished by adding the corresponding epitope peptide into the immunOBlot medium.
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Zhenbao Pill reduces the percentage of Treg cells by inducing HSP27 expression.
Yanqiang Huan,Yongxiong He,Bin Liu,Yutang Li,Lizhou Jia,Chenhui Qu,Bokang Lv,Xingyu Zhang,Hao Peng +8 more
TL;DR: In the process of repairing the SCI, Zhenbao pill inhibits reduces numbers of Treg lymphocytes as well as TGF-β levels by inducing HSP27 expression, which indicated that the expression of HSP 27 regulated the differentiation into Tregs.
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Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO.
Huey Jen Tsay,Yung Cheng Huang,Yi Jen Chen,Yun Hao Lee,Shu Meng Hsu,Keng-Chang Tsai,Cheng Ning Yang,Fong Lee Huang,Feng Shiun Shie,Lin Chien Lee,Young Ji Shiao +10 more
TL;DR: This study reveals that N-glycan moiety is more critical than SRCR domain for SR-A-mediated oAβ internalization.
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MicroRNA-148b regulates megalin expression and is associated with receptor downregulation in mice with unilateral ureteral obstruction
Lu Wen,Lu Wen,Pia K. Andersen,Dina Michelle Unnerup Husum,Rikke Nørregaard,Zhanzheng Zhao,Zhangsuo Liu,Henrik Birn,Henrik Birn +8 more
TL;DR: The findings suggest that miR-148b directly downregulates megalin expression and thatmiR- 148b negatively regulates megalIn expression in UUO-induced kidney injury, and the identification of a miRNA regulating megal in expression may allow for targeted interventions to modulate meGalin function and proximal tubule uptake of proteins, as well as other ligands.