Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.
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TLDR
An overview on microRNAs that are involved in the Aβ cascade and their inhibitory impact on their target mRNAs whose products participate in Aβ clearance is discussed.Citations
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CRISPR-Cas12a (Cpf1): A Versatile Tool in the Plant Genome Editing Tool Box for Agricultural Advancement.
Anindya Bandyopadhyay,Nagesh Kancharla,Vivek S. Javalkote,Santanu Dasgupta,Thomas P. Brutnell +4 more
TL;DR: A comparative survey of CRISPR-Cas12a and Cas9 is provided, and a perspective on applications of CRisPR- Cas12 in agriculture is provided.
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miR-34a in Neurophysiology and Neuropathology.
TL;DR: The known and emerging roles of the miR-34a regulatory network in neurophysiology and neuropathology are discussed and modulated by factors that control its expression as well as its downstream target genes and signaling pathways.
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Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis
Weiying Sun,Jun Zhao,Chunzhi Li +2 more
TL;DR: The findings showed that Dex administration resulted in the enhancement of miR-129 expression with declined hippocampal neuron apoptosis and attenuated cognitive impairment in Aβ1–42-injected mice, suggesting the miR -129/YAP1/JAG1 axis could potentially be the mechanism by which Dex protects AD mice from cognitive impairment.
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MicroRNA-7: expression and function in brain physiological and pathological processes
TL;DR: In-depth studies on the role of miR-7 in brain physiology and pathology undoubtedly not only provide a light on the roles of miRNAs in brain development and diseases, but also are much helpful for ultimate development of therapeutic strategies against brain diseases.
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Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression
Omayma A.R. AboZaid,M. W. Sallam,Sawsan M El-Sonbaty,Samy Ali Hussein Aziza,Basma Emad,Esraa S. A. Ahmed +5 more
TL;DR: N nano-formulation of resveratrol with selenium maximized the therapeutic potential of RSV against Alzheimer’s disease not only by their antioxidant but also by anti-inflammatory effect improving the neurocognitive function and modulating the signaling pathways.
References
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Degradation of Amyloid β Protein by Purified Myelin Basic Protein
TL;DR: It is shown that Aβ40 and Aβ42 peptides are degraded by purified human brain MBP and recombinant human MBP, but not an MBP fragment that lacks autolytic activity, which indicates that purified MBP possesses Aβ degrading activity in vitro.
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MiR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells.
Daguia Zambe John Clotaire,Bin Zhang,Na Wei,Rongfang Gao,Fei Zhao,Yunfei Wang,Ming Lei,Weiwei Huang +7 more
TL;DR: It is found that miR-26b inhibited autophagy in PC-3 and C4-2 cells, through down-regulation of ULK2 expression, which is up-regulated in PCa.
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MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts.
TL;DR: Evidence is provided for the role of miR-17 as a negative regulator of TNF-α signaling by modulating the protein ubiquitin processes in RA SFs.
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miR-194 targets RBX1 gene to modulate proliferation and migration of gastric cancer cells.
TL;DR: It was found that miR-194 was significantly downregulated and RBX1 upregulated in GC tissues; both of which showed significant association with tumor size, location, invasion, and tumor node metastasis.
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Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line
TL;DR: Results suggest, for the first time, that an epigenetic mechanism involving an aluminum-triggered, NF-kB-sensitive, miRNA-34a-mediated down-regulation of TREM2 expression may impair phagocytic responses that ultimately contribute to Aβ42 peptide accumulation, aggregation, amyloidogenesis and inflammatory degeneration in the brain.