Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.
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TLDR
An overview on microRNAs that are involved in the Aβ cascade and their inhibitory impact on their target mRNAs whose products participate in Aβ clearance is discussed.Citations
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CRISPR-Cas12a (Cpf1): A Versatile Tool in the Plant Genome Editing Tool Box for Agricultural Advancement.
Anindya Bandyopadhyay,Nagesh Kancharla,Vivek S. Javalkote,Santanu Dasgupta,Thomas P. Brutnell +4 more
TL;DR: A comparative survey of CRISPR-Cas12a and Cas9 is provided, and a perspective on applications of CRisPR- Cas12 in agriculture is provided.
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miR-34a in Neurophysiology and Neuropathology.
TL;DR: The known and emerging roles of the miR-34a regulatory network in neurophysiology and neuropathology are discussed and modulated by factors that control its expression as well as its downstream target genes and signaling pathways.
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Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis
Weiying Sun,Jun Zhao,Chunzhi Li +2 more
TL;DR: The findings showed that Dex administration resulted in the enhancement of miR-129 expression with declined hippocampal neuron apoptosis and attenuated cognitive impairment in Aβ1–42-injected mice, suggesting the miR -129/YAP1/JAG1 axis could potentially be the mechanism by which Dex protects AD mice from cognitive impairment.
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MicroRNA-7: expression and function in brain physiological and pathological processes
TL;DR: In-depth studies on the role of miR-7 in brain physiology and pathology undoubtedly not only provide a light on the roles of miRNAs in brain development and diseases, but also are much helpful for ultimate development of therapeutic strategies against brain diseases.
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Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer’s Disease by Regulating Sirt1/miRNA-134/GSK3β Expression
Omayma A.R. AboZaid,M. W. Sallam,Sawsan M El-Sonbaty,Samy Ali Hussein Aziza,Basma Emad,Esraa S. A. Ahmed +5 more
TL;DR: N nano-formulation of resveratrol with selenium maximized the therapeutic potential of RSV against Alzheimer’s disease not only by their antioxidant but also by anti-inflammatory effect improving the neurocognitive function and modulating the signaling pathways.
References
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Journal ArticleDOI
Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.
Micha M.M. Wilhelmus,Wilbert C. Boelens,Irene Otte-Höller,Bram Kamps,Robert M.W. de Waal,Marcel M. Verbeek +5 more
TL;DR: In this paper, small heat shock proteins Hsp20 and HspB2/B3 co-localize with Abeta deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains, respectively.
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MicroRNAs and Neurodegeneration: Role and Impact
TL;DR: This work focuses on emerging roles of miRNAs in age-associated events impacting long-term brain integrity and neurodegenerative disease.
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ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood–Brain Barrier for Aβ1–40 Peptides
Huaqi Xiong,Debbie Callaghan,Aimee Jones,Jianying Bai,Ingrid Rasquinha,Catherine Smith,Ke Pei,Douglas G. Walker,Lih-Fen Lue,Danica Stanimirovic,Wandong Zhang +10 more
TL;DR: Results suggest that ABCG2 may act as a gatekeeper at the BBB to prevent blood Aβ from entering into brain and may serve as a biomarker of CAA vascular pathology in AD patients.
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MiR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression.
Jaekwang Kim,Hyejin Yoon,Cristina M. Ramírez,Sang Mi Lee,Hyang Sook Hoe,Carlos Fernández-Hernando,Jungsu Kim +6 more
TL;DR: The data suggest that miR-106b affects Aβ metabolism by suppressing ABCA1 expression, and may provide new strategy for regulating cholesterol metabolism and amyloid β levels.
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The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells.
Katharina Rothe,Hanyang Lin,Hanyang Lin,Kevin B. L. Lin,Amy Leung,Hui Mi Wang,Mehrnoush Malekesmaeili,Ryan R. Brinkman,Donna L. Forrest,Sharon M. Gorski,Xiaoyan Jiang +10 more
TL;DR: It is demonstrated that several key autophagy genes are differentially expressed in CD34(+) hematopoietic stem/progenitor cells, with the highest transcript levels detected for ATG4B, and that the transcript and protein expression levels of ATG 4 family members, ATG5 and BECLIN-1 are significantly increased in CD 34(+) cells from chronic-phase CML patients.