Prenylated xanthone derivatives with antiplasmodial activity from Allanblackia monticola STANER L.C.
Anatole Guy Blaise Azebaze,Michele Meyer,Alexis Valentin,Edwige Laure Nguemfo,Zacharias Tanee Fomum,Augustin Ephrem Nkengfack +5 more
TLDR
The methanol extract and pure compounds were tested on two strains of Plasmodium falciparum, F32 ( chloroquine sensitive) and FcM29 (chloroquine resistant) and the IC50 values obtained ranged from 0.6 to 8.9 microg/ml.Abstract:
Further study of the methanol extract of the stem bark of Allanblackia monticola STANER L.C. resulted in the isolation of a new prenylated xanthenedione, designated allanxanthone C, together with the five known xanthones, garciniafuran, tovophyllin A, rubraxanthone, norcowanin and mangostin and one saponin, stigmasterol-3-O-beta-D-glucopyranoside. The structure of the new compound was established by detailed spectroscopic analysis to be 1,2-dihydro-3,6,8-trihydroxy-1,1,7-tri(3-methylbut-2-enyl)xanthen-2,9-dione (3-hydroxyapetalinone C). The methanol extract and pure compounds were tested on two strains of Plasmodium falciparum, F32 (chloroquine sensitive) and FcM29 (chloroquine resistant). The IC50 values obtained ranged from 0.6 to 8.9 microg/ml. Their cytotoxicity was estimated on human melanoma cells (A375) and the cytotoxicity/antiplasmodial ratio was found to be between 15.45 and 30.46. The antimicrobial activities against a range of microorganisms of the crude extract and some of these compounds are also reported.read more
Citations
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Medicinal properties of mangosteen (Garcinia mangostana).
TL;DR: Findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far are summarized.
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The antimalarial potential of medicinal plants used for the treatment of malaria in Cameroonian folk medicine.
TL;DR: The present study shows that Cameroonian flora represents a high potential for new antimalarial compounds and further ethnobotanical surveys and laboratory investigations are needed to fully exploit the potential of the identified species in the control of malaria.
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The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.
Fidele Ntie-Kang,Fidele Ntie-Kang,Pascal Amoa Onguéné,Lydia L. Lifongo,Jean Claude Ndom,Wolfgang Sippl,Luc Meva'a Mbaze +6 more
TL;DR: Data available in the literature indicated that African flora hold an enormous potential for the development of phytomedicines for malaria, and an attempt has been made to assess the value of African medicinal plants for drug discovery by discussing the anti-malarial virtue of the derived phytochemicals that have been tested by in vitro and in vivo assays.
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Antimalarial compounds isolated from plants used in traditional medicine.
TL;DR: Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties and can play a role in the development of new antimalarial drugs.
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Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis
Quan-Bin Han,Nian-Yun Yang,Hong-Lei Tian,Chun-Feng Qiao,Jing-Zheng Song,Donald C. Chang,Shilin Chen,Kathy Qian Luo,Hong-Xi Xu +8 more
TL;DR: Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis and the cytotoxic activities of these compounds were evaluated using the MTT method.
References
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Journal ArticleDOI
Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.
TL;DR: A rapid, semiautomated microdilution method was developed for measuring the activity of potential antimalarial drugs against cultured intraerythrocytic asexual forms of the human malaria parasite Plasmodium falciparum, and results demonstrated that the method is sensitive and precise.
Journal ArticleDOI
Tetraoxygenated naturally occurring xanthones
Valdir Peres,Tanus Jorge Nagem +1 more
TL;DR: This review, with 350 references, gives information on the chemical study of 234 naturally occurring tetraoxygenated xanthones in 12 families, 53 genus and 182 species of higher plants, and two which are described as fungal and lichen metabolites.
Journal ArticleDOI
Les plantes utiles du Gabon
André Raponda-Walker,R. Sillans +1 more
TL;DR: In this paper, Les Plantes Utiles Du Gabon (LUTG) is used as an example of a plant that can be found in Gabon, and the authors present their work.
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Guttiferone F, the first prenylated benzophenone from Allanblackia stuhlmannii.
TL;DR: The HIV-inhibitory activity in extracts of Allanblackia stuhlmannii was tracked, via bioassay-guided fractionation, to a new member of the camboginol/guttiferone class of prenylated benzophenones, guttiferone F.
Journal ArticleDOI
Mangostanol, a prenyl xanthone from Garcinia mangostana
TL;DR: In this paper, a new polyoxygenated xanthone mangostanol was isolated from the fruit hull of Garcinia mangostana, along with known xanthones, α-mangostin, γ-mengostin and gartanin, 8-deoxygartnin, 5,9-dihydroxy-2,2-dimethyl-8-methoxy-7-(3-methylbut-2-enyl)-2 H,6 H -pyrano[3, 2-b ]xanthen