Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study
Angela Dispenzieri,Jerry A. Katzmann,Robert A. Kyle,Dirk R. Larson,L. Joseph Melton,Colin L. Colby,Terry M. Therneau,Raynell J. Clark,Shaji Kumar,Arthur R. Bradwell,Rafael Fonseca,D F Jelinek,S. Vincent Rajkumar +12 more
TLDR
Age-specific and sex-specific prevalence and rates of progression to lymphoproliferative disorders for light-chain and conventional MGUS and assessed incidence of renal disorders in patients with light- chain MGUS are calculated.About:
This article is published in The Lancet.The article was published on 2010-05-15 and is currently open access. It has received 292 citations till now. The article focuses on the topics: Monoclonal gammopathy of undetermined significance & Population.read more
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International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
S. Vincent Rajkumar,Meletios A. Dimopoulos,Antonio Palumbo,Joan Bladé,Giampaolo Merlini,Maria-Victoria Mateos,Shaji Kumar,Jens Hillengass,Efstathios Kastritis,Paul G. Richardson,Ola Landgren,Bruno Paiva,Angela Dispenzieri,Brendan M. Weiss,Xavier Leleu,Sonja Zweegman,Sagar Lonial,Laura Rosiñol,Elena Zamagni,Sundar Jagannath,O. Sezer,Sigurdur Y. Kristinsson,Jo Caers,Saad Z. Usmani,Juan José Lahuerta,Hans Erik Johnsen,Meral Beksac,Michele Cavo,Hartmut Goldschmidt,Evangelos Terpos,Robert A. Kyle,Kenneth C. Anderson,Brian G.M. Durie,Jesús F. San Miguel +33 more
TL;DR: The disease definition of multiple myeloma is updated to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions), and specific metrics that new biomarkers should meet for inclusion in the disease definition are provided.
Journal ArticleDOI
Multiple myeloma: 2020 update on diagnosis, risk-stratification and management.
TL;DR: Multiple myeloma accounts for approximately 10% of hematologic malignancies in the United States and is the second most common cancer in women.
Journal ArticleDOI
Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management.
TL;DR: The diagnosis requires ≥10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE): CRAB, serum involved/uninvolved free light chain (FLC) ratio, or >1 focal lesion on magnetic resonance imaging.
Journal ArticleDOI
Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance.
Robert A. Kyle,Dirk R. Larson,Terry M. Therneau,Angela Dispenzieri,Shaji Kumar,James R. Cerhan,S. Vincent Rajkumar +6 more
TL;DR: Overall survival was shorter among patients with MGUS than was expected in a matched control population and the presence of two adverse risk factors — namely, an abnormal serum free light‐chain ratio and a high serum monoclonal protein level — was associated with a risk of progression at 20 years.
Journal ArticleDOI
International Myeloma Working Group Consensus Statement for the Management, Treatment, and Supportive Care of Patients With Myeloma Not Eligible for Standard Autologous Stem-Cell Transplantation
Antonio Palumbo,S. Vincent Rajkumar,Jesús F. San Miguel,Alessandra Larocca,Ruben Niesvizky,Gareth J. Morgan,Ola Landgren,Roman Hájek,Hermann Einsele,Kenneth C. Anderson,Meletios A. Dimopoulos,Paul G. Richardson,Michele Cavo,Andrew Spencer,A. Keith Stewart,Kazuyuki Shimizu,Sagar Lonial,Pieter Sonneveld,Brian G.M. Durie,Philippe Moreau,Robert Z. Orlowski +20 more
TL;DR: An update on recent advances in the management of patients with multiple myeloma who are not eligible for autologous stem-cell transplantation is provided to help clinicians ensure the most appropriate care for patients with Myeloma in everyday clinical practice.
References
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OtherDOI
Generalized Additive Models
Trevor Hastie,Robert Tibshirani +1 more
TL;DR: The generalized additive model (GA) as discussed by the authors is a generalization of the generalized linear model, which replaces the linear model with a sum of smooth functions in an iterative procedure called local scoring algorithm.
Book
Modeling Survival Data: Extending the Cox Model
TL;DR: A Cox Model-based approach was used to estimate the Survival and Hazard Functions and the results confirmed the need for further investigation into the role of natural disasters in shaping survival rates.
Journal ArticleDOI
International staging system for multiple myeloma.
Philip R. Greipp,Jesús F. San Miguel,Brian G.M. Durie,John Crowley,Bart Barlogie,Joan Bladé,Mario Boccadoro,J. Anthony Child,Hervé Avet-Loiseau,Robert A. Kyle,Juan J. Lahuerta,Heinz Ludwig,Gareth J. Morgan,R. L. Powles,Kazuyuki Shimizu,Chaim Shustik,Pieter Sonneveld,Patrizia Tosi,Ingemar Turesson,Jan Westin +19 more
TL;DR: The new International Staging System (ISS) is simple, based on easy to use variables (Sbeta2M and serum albumin), and recommended for early adoption and widespread use.
Journal ArticleDOI
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group
Robert A. Kyle,J. Anthony Child,Kenneth C. Anderson,Bart Barlogie,Régis Bataille,William I. Bensinger,Joan Bladé,Mario Boccadoro,William S. Dalton,Meletios A. Dimopoulos,Benjamin Djulbegovic,Mark T. Drayson,Brian G.M. Durie,Thiery Facon,Rafael Fonseca,Gösta Gahrton,Philip R. Greipp,Jean Luc Harousseau,David P. Harrington,Mohamad A. Hussein,Douglas E. Joshua,Heinz Ludwig,Gareth J. Morgan,Martin M. Oken,R. L. Powles,Paul G. Richardson,David Roodman,Jesús F. San Miguel,Kazuyuki Shimizu,Chaim Shustik,Bhawna Sirohi,Pieter Sonneveld,Guido J Tricot,Ingemar Turesson,Brian G Van Ness,David H. Vesole,Donna M. Weber,Jan Westin,Keith Wheatley +38 more
TL;DR: The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations to facilitate comparison of therapeutic trial data.
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International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
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