Journal ArticleDOI
Prevalence of rapid eye movement sleep behavior disorder (RBD) in Parkinson’s disease: a meta and meta-regression analysis
TLDR
The results indicate that nearly half of the PD patients are suffering from RBD, and older age and longer duration are risk factors for RBD in PD.Abstract:
Rapid eye movement sleep behavior disorder (RBD) is thought to be one of the most frequent preceding symptoms of Parkinson’s disease (PD). However, the prevalence of RBD in PD stated in the published studies is still inconsistent. We conducted a meta and meta-regression analysis in this paper to estimate the pooled prevalence. We searched the electronic databases of PubMed, ScienceDirect, EMBASE and EBSCO up to June 2016 for related articles. STATA 12.0 statistics software was used to calculate the available data from each research. The prevalence of RBD in PD patients in each study was combined to a pooled prevalence with a 95 % confidence interval (CI). Subgroup analysis and meta-regression analysis were performed to search for the causes of the heterogeneity. A total of 28 studies with 6869 PD cases were deemed eligible and included in our meta-analysis based on the inclusion and exclusion criteria. The pooled prevalence of RBD in PD was 42.3 % (95 % CI 37.4–47.1 %). In subgroup analysis and meta-regression analysis, we found that the important causes of heterogeneity were the diagnosis criteria of RBD and age of PD patients (P = 0.016, P = 0.019, respectively). The results indicate that nearly half of the PD patients are suffering from RBD. Older age and longer duration are risk factors for RBD in PD. We can use the minimal diagnosis criteria for RBD according to the International Classification of Sleep Disorders to diagnose RBD patients in our daily work if polysomnography is not necessary.read more
Citations
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Journal ArticleDOI
New evidence on the management of Lewy body dementia.
John-Paul Taylor,Ian G. McKeith,David J. Burn,Brad F. Boeve,Daniel Weintraub,Daniel Weintraub,Claire Bamford,Louise Allan,Alan J. Thomas,John T. O'Brien +9 more
TL;DR: Clinical trials and meta-analyses now provide an evidence base for the treatment of cognitive, neuropsychiatric, and motor symptoms in patients with Lewy body dementia, and consensus opinion from experts supports the application of treatments for related conditions, such as Parkinson's disease, for the management of common symptoms.
Journal ArticleDOI
Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnographic findings.
Ye Zhang,Rong Ren,Larry D. Sanford,Linghui Yang,Junying Zhou,Lu Tan,Taomei Li,Jihui Zhang,Yun Kwok Wing,Jie Shi,Lin Lu,Xiangdong Tang +11 more
TL;DR: This study suggests that PD patients have poor sleep quality and quantity, and identifies factors that contributed to heterogeneity between studies.
Journal ArticleDOI
An overview of sleep and circadian dysfunction in Parkinson's disease
Susanna Mantovani,Susanna Mantovani,Simon Smith,Richard D. Gordon,John D. O'Sullivan,John D. O'Sullivan +5 more
TL;DR: This narrative review provides an overview on the frequency of excessive daytime sleepiness, insomnia, restless legs, obstructive apnea and nocturia in Parkinson's disease, as well as addressing sleep structure, rapid eye movement sleep behaviour disorder and circadian features in Parkinson’s disease.
Journal ArticleDOI
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis
Geraldine Hipp,Michel Vaillant,Nico J. Diederich,Kirsten Roomp,Venkata P. Satagopam,Peter Banda,Estelle Sandt,Kathleen Mommaerts,Sabine K. Schmitz,Laura Longhino,Alexandra Schweicher,Anne-Marie Hanff,Béatrice Nicolai,Pierre Kolber,Pierre Kolber,Dorothea Reiter,Dorothea Reiter,Lukas Pavelka,Lukas Pavelka,Sylvia Binck,Sylvia Binck,Claire Pauly,Claire Pauly,Lars Geffers,Fay Betsou,Manon Gantenbein,Jochen Klucken,Thomas Gasser,Michele T.M. Hu,Rudi Balling,Rejko Krüger,Rejko Krüger +31 more
TL;DR: The Luxembourg Parkinson’s study is envisioned as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches and an open-source digital platform that can be harmonized with international PD cohort studies is implemented.
Book ChapterDOI
Sleep Dysfunction in Parkinson's Disease.
TL;DR: This chapter will focus on reviewing the main characteristics, pathophysiology, assessment, and management of the most frequent sleep disturbances encountered in Parkinson's disease.
References
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Journal ArticleDOI
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Journal ArticleDOI
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