pROC: an open-source package for R and S+ to analyze and compare ROC curves
Xavier Robin,Natacha Turck,Alexandre Hainard,Natalia Tiberti,Frédérique Lisacek,Jean-Charles Sanchez,Markus Müller +6 more
TLDR
pROC as mentioned in this paper is a package for R and S+ that contains a set of tools displaying, analyzing, smoothing and comparing ROC curves in a user-friendly, object-oriented and flexible interface.Abstract:
Receiver operating characteristic (ROC) curves are useful tools to evaluate classifiers in biomedical and bioinformatics applications. However, conclusions are often reached through inconsistent use or insufficient statistical analysis. To support researchers in their ROC curves analysis we developed pROC, a package for R and S+ that contains a set of tools displaying, analyzing, smoothing and comparing ROC curves in a user-friendly, object-oriented and flexible interface. With data previously imported into the R or S+ environment, the pROC package builds ROC curves and includes functions for computing confidence intervals, statistical tests for comparing total or partial area under the curve or the operating points of different classifiers, and methods for smoothing ROC curves. Intermediary and final results are visualised in user-friendly interfaces. A case study based on published clinical and biomarker data shows how to perform a typical ROC analysis with pROC. pROC is a package for R and S+ specifically dedicated to ROC analysis. It proposes multiple statistical tests to compare ROC curves, and in particular partial areas under the curve, allowing proper ROC interpretation. pROC is available in two versions: in the R programming language or with a graphical user interface in the S+ statistical software. It is accessible at http://expasy.org/tools/pROC/
under the GNU General Public License. It is also distributed through the CRAN and CSAN public repositories, facilitating its installation.read more
Citations
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Journal ArticleDOI
Interaction between lifestyle and genetic susceptibility in myopia: the Generation R study
Clair A. Enthoven,Jan Willem L Tideman,Jan Roelof Polling,Milly S. Tedja,Hein Raat,Adriana I Iglesias,Virginie J. M. Verhoeven,Caroline C W Klaver,Caroline C W Klaver +8 more
TL;DR: Evidence is provided that nature and nurture are equally important for myopia and AL/CR; however, the combination has the strongest influence.
Journal ArticleDOI
Identification of prognostic markers for hepatocellular carcinoma based on miRNA expression profiles.
TL;DR: Functional enrichment analysis showed that these key miRNAs were involved in multiple biological processes, such as telomere maintenance via telomerase, protein sumoylation, histone mRNA metabolic process and angiotensin maturation, which might serve as new diagnostic markers and therapeutic targets for HCC.
Journal ArticleDOI
Development and validation of a decision tree early warning score based on routine laboratory test results for the discrimination of hospital mortality in emergency medical admissions
Stuart William Jarvis,Caroline Kovacs,Tessy Badriyah,Jim Briggs,Mohammed A Mohammed,Mohammed A Mohammed,Paul Meredith,Paul E. Schmidt,Peter I. Featherstone,David Prytherch,Gary B. Smith +10 more
TL;DR: Evidence is provided that the results of commonly measured laboratory tests collected soon after hospital admission can be represented in a simple, paper-based EWS (LDT-EWS) to discriminate in-hospital mortality.
Journal ArticleDOI
Fire, livestock grazing, topography, and precipitation affect occurrence and prevalence of cheatgrass ( Bromus tectorum ) in the central Great Basin, USA
Matthew A. Williamson,Matthew A. Williamson,Erica Fleishman,Erica Fleishman,Ralph Charles Mac Nally,Ralph Charles Mac Nally,Jeanne C. Chambers,Bethany A. Bradley,David S. Dobkin,David I. Board,Frank A. Fogarty,Ned Horning,Matthias Leu,Martha Wohlfeil Zillig +13 more
TL;DR: No support is provided for the notion that contemporary grazing regimes or grazing in conjunction with fire can suppress cheatgrass, and time-series data and results indicate that grazing corresponds with increased cheatgrass occurrence and prevalence regardless of variation in climate, topography, or community composition.
Journal ArticleDOI
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease
Shorena Janelidze,Divya Bali,Nicholas J. Ashton,Nicolas R. Barthélemy,Jeroen Vanbrabant,Erik Stoops,Eugeen Vanmechelen,Yingxin He,Anna Orduña Dolado,Gallen B. Triana-Baltzer,Michael J. Pontecorvo,Henrik Zetterberg,Hartmuth C. Kolb,Manu Vandijck,Kaj Blennow,Randall J. Bateman,Oskar Hansson +16 more
TL;DR: It is suggested that among all tested plasma p-tau assays, mass spectrometry-based measures of p- tau217 perform best when identifying mild cognitive impairment patients with abnormal brain Aβ or those who will subsequently progress to Alzheimer's dementia.
References
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