Journal ArticleDOI
Production of IGF-binding proteins by vascular endothelial cells.
Robert S. Bar,Leonard C. Harrison,Leonard C. Harrison,Leonard C. Harrison,Robert C. Baxter,Robert C. Baxter,Robert C. Baxter,Mary Boes,Mary Boes,Mary Boes,Brian L. Dake,Brian L. Dake,Brian L. Dake,Barbara A. Booth,Barbara A. Booth,Barbara A. Booth,Alison J. Cox,Alison J. Cox,Alison J. Cox +18 more
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TLDR
It is concluded that endothelial cells in culture produce large quantities of specific IGF binding proteins, which should be relevant in understanding the complex metabolism and function of the IGFs in the intact host.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1987-10-29. It has received 62 citations till now. The article focuses on the topics: Binding protein & Vascular endothelial growth factor A.read more
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Book ChapterDOI
Insulin-like growth factor binding proteins.
TL;DR: This chapter discusses the insulin-like growth factor (IGF) binding proteins—namely, IGF-I and IGF-II, which are single-chain 7.5-kDa polypeptides that are chemically related to insulin.
Journal ArticleDOI
Binding proteins for the insulin-like growth factors: structure, regulation and function
Robert C. Baxter,Janet L. Martin +1 more
TL;DR: This review outlines the purification and characterization of the binding proteins that have been identified to date, and describes the regulation of their production and of their levels in the circulation.
Journal ArticleDOI
Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 Binding Proteins in Blood Vessels
TL;DR: Evidence implicating involvement of the vascular insulin-like growth factor system in vascular diseases, including atherosclerosis, hypertension, restenosis, angiogenesis, and diabetic vascular disease is summarized.
Journal ArticleDOI
Insulin-like growth factor binding proteins in maternal serum throughout gestation and in the puerperium: effects of a pregnancy-associated serum protease activity.
TL;DR: There was no change in the serum profile of any of the binding proteins in early pregnancy compared to that in the secretory phase of the menstrual cycle, but there was a marked decrease in circulating levels of the main serum IGFBP, IGFBP-3, after 6 weeks of gestation, continuing progressively to term and returning to nonpregnant levels by 5 days postpartum.
Journal ArticleDOI
Radioimmunoassay of a 26,000-dalton plasma insulin-like growth factor-binding protein: control by nutritional variables.
TL;DR: The plasma concentrations of the 26K IGF-I-BP fluctuate widely in response to dietary manipulation, whereas GH status appears to be a secondary controlling variable.
References
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Journal ArticleDOI
Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA
TL;DR: It is demonstrated that it is possible to culture morphologically and immunologically identifiable human endothelial cells for periods up to 5 mo and ABH antigens appropriate to the tissue donor's blood type were not detectable on cultured smooth muscle cells or fibroblasts.
Journal ArticleDOI
Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta.
TL;DR: Data showed that vascular cells have insulin and IGF receptors, but have a differential response to these hormones, which could provide clues to understanding the pathogenesis of diabetic micro- and macroangiopathy.
Journal ArticleDOI
Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.
Paul F. Pilch,Michael P. Czech +1 more
Journal ArticleDOI
Isolation and culture of microvascular endothelium from human adipose tissue.
TL;DR: C cultures of human microvascular endothelium were readily obtained from adipose tissue and required only standard medium with 10% serum for growth and subcultivation, which can be used to study human endothelial cell biology and may prove useful in the study of pathologic states such as diabetic microvasculopathy and tumor angiogenesis.
Journal ArticleDOI
The isolation and culture of capillary endothelium from epididymal fat.
TL;DR: Capillaries were isolated from collagenase-dissociated epididymal fat by centrifugation to remove floating adipocytes and subsequent filtering to remove blood elements and free stromal cells and revealed that micropinocytic vesicles were present in abundance both at the cell's free surfaces and enclosed within the cytoplasm.