Journal ArticleDOI
Prognostic value of perfusion-weighted imaging in brain glioma: a prospective study
TLDR
In this paper, the authors evaluated whether perfusion-weighted MR imaging (PWI) could usefully implement the routine preoperative imaging by detecting those areas bearing a higher yield for malignancy.Abstract:
Object. Biopsy targeting based on MR imaging alone may fail to identify malignant areas in brain gliomas. Considering the differences in relative Cerebral Blood Volume (rCBV) ratios reported among tumour grades, we evaluated whether perfusion-weighted MR imaging (PWI) could usefully implement the routine preoperative imaging by detecting those areas bearing a higher yield for malignancy to guide the stereotactic biopsy or the surgical removal. Clinical material and methods. We studied a series of 55 consecutive patients with newly diagnosed brain glioma using both conventional MR imaging and PWI in the preoperative assessment. The pathological diagnosis was established by stereotactic biopsy in 29 cases and by craniotomy in 24 cases. We evaluated the patient survival to detect undergrading. Discussion. Independent from contrast-enhancement, perfusion-weighted MR imaging improved the target selection in stereotactic biopsy guidance and the removal of malignant areas in tumours amenable to surgery. Particularly sensitive to the perfused part of the tumour as to small regional changes, rCBV maps allowed a better detection of malignant areas. The rCBV ratios correlated significantly to the tumour grade and the final outcome (p < 0.01). Conclusions. We found PWI valuable in the preoperative assessment of brain gliomas, discriminating high from low-grade gliomas. PWI can easily be performed on widely available MR imaging systems as part of the routine imaging of gliomas.read more
Citations
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Journal ArticleDOI
Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques.
Luke Macyszyn,Hamed Akbari,Jared M. Pisapia,Xiao Da,Mark A. Attiah,Vadim Pigrish,Yingtao Bi,Sharmistha Pal,Ramana V. Davuluri,Laura Roccograndi,Nadia Dahmane,Maria Martinez-Lage,George Biros,Ronald L. Wolf,Michel Bilello,Donald M. O'Rourke,Christos Davatzikos +16 more
TL;DR: The results reveal that when imaging markers related to infiltration, cell density, microvascularity, and blood-brain barrier compromise are integrated via advanced pattern analysis methods, they form very accurate predictive biomarkers.
Journal ArticleDOI
The role of radiotherapy in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
TL;DR: Target population Adult patients (age ≥18 years) who have suspected low-grade diffuse glioma and are likely to have a history of central giant cell granuloma.
Journal ArticleDOI
Advanced MRI of adult brain tumors.
TL;DR: Clinical neurologists are provided with a summary of recent clinical experience in application of these major advanced MRI techniques to differential diagnosis, grading, surgical planning, and monitoring of therapeutic response of tumors.
Journal ArticleDOI
Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence
Friso W. A. Hoefnagels,Frank J. Lagerwaard,Esther Sanchez,Cornelis J.A. Haasbeek,Dirk L. Knol,Ben J. Slotman,W. Peter Vandertop +6 more
TL;DR: Perfusion MRI seems to be a useful tool in the differentiation of necrosis and tumor recurrence after SRS, and Salvage treatment can be initiated for these patients in an attempt to prolong survival.
Journal ArticleDOI
Dynamic susceptibility contrast MRI measures of relative cerebral blood volume as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 multicenter trial.
Kathleen M. Schmainda,Zheng Zhang,Melissa Prah,Bradley S. Snyder,Mark R. Gilbert,A. Gregory Sorensen,Daniel P. Barboriak,Jerrold L. Boxerman +7 more
TL;DR: Early decreases in rCBV are predictive of improved survival in patients with recurrent GBM treated with bevacizumab.
References
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Journal ArticleDOI
Perfusion imaging with NMR contrast agents
TL;DR: The use of MR contrast agents to measure tissue perfusion is reviewed, and the potential of contrast‐enhanced NMR for high resolution in vivo mapping of both physiology and anatomy is suggested.
Journal Article
Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging
Meng Law,Stanley Yang,Hao Wang,James S. Babb,James S. Babb,Glyn Johnson,Soonmee Cha,Edmond A. Knopp,David Zagzag +8 more
TL;DR: The rCBV measurements had the most superior diagnostic performance (either with or without metabolite ratios) in predicting glioma grade and can be used in a clinical setting to evaluate tumors preoperatively for histologic grade and provide a means for guiding treatment and predicting postoperative patient outcome.
Journal ArticleDOI
Cerebral blood volume maps of gliomas : comparison with tumor grade and histologic findings
Hannu J. Aronen,I. E. Gazit,David N. Louis,Bradley R. Buchbinder,Francisco S. Pardo,Robert M. Weisskoff,Griffith R. Harsh,Cosgrove Gr,Elkan F. Halpern,Fred H. Hochberg +9 more
TL;DR: MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.
Journal ArticleDOI
Glucose utilization of cerebral gliomas measured by [18F] fluorodeoxyglucose and positron emission tomography
G. Di Chiro,R L DeLaPaz,Rodney A. Brooks,L. Sokoloff,Paul L. Kornblith,Barry H. Smith,Nicholas J. Patronas,Conrad V. Kufta,R. M. Kessler,Gerald S. Johnston,R. G. Manning,Alfred P. Wolf +11 more
TL;DR: A correlation between rate of glycolysis and malignancy in primary cerebral tumors is found and Cerebral cortical glucose utilization was often depressed in areas adjacent to or neurally connected to the tumor site, and there was focal irregular delta wave EEG activity in these areas.
Journal ArticleDOI
Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging.
Edmond A. Knopp,Soonmee Cha,Glyn Johnson,Avi Mazumdar,John G. Golfinos,David Zagzag,Douglas C. Miller,Patrick J. Kelly,Irvin I. Kricheff +8 more
TL;DR: Echo-planar perfusion imaging is useful in the preoperative assessment of tumor grade and in providing diagnostic information not available with conventional MR imaging.