Progress towards the Development of a Universal Influenza Vaccine
TLDR
This review provides the latest progress in the development of universal influenza vaccines and identifies several innovative strategies and vaccine platforms being explored to generate robust cross-protective immunity.Abstract:
Influenza viruses are responsible for millions of cases globally and significantly threaten public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 years and some of the viruses have resulted in high mortality in humans, a universal influenza vaccine is needed to provide comprehensive protection against a wide range of influenza viruses. Current seasonal influenza vaccines provide strain-specific protection and are less effective against mismatched strains. The rapid antigenic drift and shift in influenza viruses resulted in time-consuming surveillance and uncertainty in the vaccine protection efficacy. Most recent universal influenza vaccine studies target the conserved antigen domains of the viral surface glycoproteins and internal proteins to provide broader protection. Following the development of advanced vaccine technologies, several innovative strategies and vaccine platforms are being explored to generate robust cross-protective immunity. This review provides the latest progress in the development of universal influenza vaccines.read more
Citations
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Improvement influenza vaccine immune responses with traditional Chinese medicine and its active ingredients
Dan Zhao,Xiu-e Chen,Lin-Yuan Wang,Jianjun Zhang,Ruilin Lv,Lin-Li Jaime Tan,Yawen Chen,Ran Tao,Xinyu Li,Yan Chen,Wei He,Jing He +11 more
TL;DR: Wang et al. as mentioned in this paper compared traditional Chinese medicine (TCM) and its active ingredients to enhance immune responses to influenza vaccine in mice and found that Astragali Radix exerts a more comprehensive effect on vaccine immunity, on both innate and adaptive immunity.
Posted ContentDOI
Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccine
TL;DR: In this paper , single-component, self-assembling protein nanoparticles (1c SApNPs) presented the conserved extracellular domain of matrix protein 2 (M2e) from influenza A viruses of human and other hosts.
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RSAD2 Is an Effective Target for High-Yield Vaccine Production in MDCK Cells
Zilin Qiao,Yuejiao Liao,Mengyuan Pei,Zhenyu Qiu,Zhenbin Liu,Dongwu Jin,Jiayou Zhang,Zhong-fa Ma,Xiaoming Yang +8 more
TL;DR: In this paper , the authors used DIA proteomics analysis technology to compare protein expression differences between two groups of MDCK cells: uninfected and influenza A virus (IAV) H1N1-infected cells 16 h post infection (MOI = 0.01).
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Broadly Protective Neuraminidase-Based Influenza Vaccines and Monoclonal Antibodies: Target Epitopes and Mechanisms of Action
TL;DR: Neuraminidase (NA) is an important surface protein on influenza virions, playing an essential role in the viral life cycle and being a key target of the immune system as mentioned in this paper .
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Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo.
TL;DR: In this article , the authors demonstrate that sodium taurocholate hydrate (STH) exhibits broad-spectrum antiviral activity against influenza strains H5N6, H1N1, H3N2 and H9N2 in vitro.
References
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