Journal ArticleDOI
Proinflammatory and immunoregulatory mechanisms in periapical lesions.
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TLDR
Th1 immune response is most probably important for all stages of periapical lesion development; Th2 and immunoregulatory cytokines are more significant for advanced types of lesions with the predominance of B cells/plasma cells; Th17 immune response seems to play a dominant role in exacerbating inflammation.About:
This article is published in Molecular Immunology.The article was published on 2009-11-01. It has received 128 citations till now. The article focuses on the topics: Proinflammatory cytokine & Dendritic cell.read more
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Host response mechanisms in periodontal diseases
Nora Silva,Loreto Abusleme,Denisse Bravo,Nicolas Dutzan,Jocelyn García-Sesnich,Rolando Vernal,Marcela Hernández,Jorge Gamonal +7 more
TL;DR: A characterization of the progression ofperiodontitis as a stage that presents a significantly host immune and inflammatory response to the microbial challenge that determine of susceptibility to develop the destructive/progressive periodontitis under the influence of multiple behavioral, environmental and genetic factors.
Journal ArticleDOI
Review of osteoimmunology and the host response in endodontic and periodontal lesions
TL;DR: Interestingly, both lesions of endodontic origin and periodontitis exhibit inflammation that appears to inhibit bone formation, and the persistence of inflammation is also thought to be important inperiodontitis since inflammation present during coupled bone formation may limit the capacity to repair the resorbed bone.
Journal ArticleDOI
Overlapping protective and destructive regulatory pathways in apical periodontitis.
Ildikó Márton,Csongor Kiss +1 more
TL;DR: A network of stimulatory and inhibitory feedback loops may influence the intensity of the defense and inflammatory responses and the balance between bone resorption and regeneration, resulting in lesion expansion or healing of apical periodontitis.
Journal ArticleDOI
Inflammatory profile of chronic apical periodontitis: a literature review
Paulo Henrique Braz-Silva,Mariana Lobo Bergamini,Andressa Pinto Mardegan,Catharina Simioni De Rosa,Bengt Hasséus,Peter Jonasson +5 more
TL;DR: Inflammatory biomarkers such as cytokines, chemokines, inflammatory cells, neuropeptides, RANK/RANKL/OPG system and other inflammatory markers are reviewed to relate these systems to the development and progression of pathological conditions related to apical periodontitis.
Journal ArticleDOI
Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status
Ana Claudia Araujo-Pires,Carolina Favaro Francisconi,Claudia Cristina Biguetti,Franco Cavalla,Franco Cavalla,Andreza Maria Fábio Aranha,Ariadne Letra,Ana Paula Favaro Trombone,Marcelo Faveri,Renato Menezes Silva,Gustavo Pompermaier Garlet +10 more
TL;DR: While the widespread cytokine expression seems to be a feature of chronic lesions, hierarchical cluster analysis demonstrates the association of TNF-α,IL-21, IL-17 and IFN-γ with lesions activity, and the association with FOXP3, IL,10, IL -9, IL the4 and IL-22 with lesions inactivity.
References
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Journal ArticleDOI
Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
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Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Wanjun Chen,Wenwen Jin,Neil J. Hardegen,Ke Jian Lei,Li Li,Nancy J. Marinos,George McGrady,Sharon M. Wahl +7 more
TL;DR: Novel evidence is presented that conversion of naive peripheral CD4+CD25− T cells into anergic/suppressor cells that are CD25+, CD45RB−/low and intracellular CTLA-4+ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor β (TGF-β).
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
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Functional diversity of helper T lymphocytes.
TL;DR: The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses.
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IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L. Mellor,David H. Munn +1 more
TL;DR: This review summarizes key recent developments and proposes a unifying model for the role of IDO in tolerance induction, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases.