Journal ArticleDOI
Propofol induces hepatocellular carcinoma cell apoptosis via regulating miR-105/JAK2/STAT3 axis.
TLDR
Wang et al. as mentioned in this paper investigated the effect of Propofol on hepatocellular carcinoma (HCC) cells and found that upregulation of miR-105 inhibited the proliferation of HCC cells, while downregulation reversed the cell apoptosis.About:
This article is published in Cytokine.The article was published on 2021-08-10. It has received 7 citations till now. The article focuses on the topics: Downregulation and upregulation & Viability assay.read more
Citations
More filters
Journal ArticleDOI
Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro
TL;DR: Ferroptosis-related signaling pathways including SLC7A11/GPX4, ubiquinol/CoQ10/FSP1, and YAP/ACSL4/TFRC were found to be changed under drug treatments and propofol showed synergistic anticancer effects with paclitaxel.
Journal ArticleDOI
Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
TL;DR: In this article, the authors summarized the current research about the effects of different anesthetics in regulating cancer, with a particular emphasis on the role of miRNAs, which are single-stranded non-coding RNAs that regulate gene expression at various levels, and their dysregulation contributes to the pathogenesis of cancers.
Journal ArticleDOI
Evaluation of the biological response of propofol in zebrafish (Danio rerio): Focusing on biochemical, transcriptional, and molecular level.
Nan Jiang,Jun Mei Wang,Qian Wang,Baikerouzi Baihetiyaer,Xianxu Li,Zhongkang Yang,Mingsheng Li,Huimin Sun,Xianqiang Yin +8 more
TL;DR: Zhang et al. as mentioned in this paper explored the toxic effects of chronic propofol exposure (0.008, 0.04, and 0.2 mg L-1) on adult zebrafish from biochemical, transcriptional, and molecular level after 7, 14, 21 and 28 days of exposure.
Journal ArticleDOI
Harnessing function of EMT in hepatocellular carcinoma: From biological view to nanotechnological standpoint.
Yaser E. Alqurashi,H. Al-Hetty,Pushpamala Ramaiah,Alaa Hameed Fazaa,Abduladheem Turki Jalil,Fahad I AlSaikhan,J. K. Gupta,Andrés Alexis Ramírez-Coronel,Nahla A. Tayyib,Hu Peng +9 more
TL;DR: In this article , the authors have evaluated the EMT mechanism and related molecular mechanisms in HCC and found that EMT is an underlying cause in increasing cancer migration and it is followed by mesenchymal transformation of epithelial cells.
Journal ArticleDOI
Long-term effect of anesthesia choice on patients with hepatocellular carcinoma undergoing open liver resection
TL;DR: In this article , the authors summarized the relations between different anesthetic choices and hepatocellular carcinoma (HCC) patients' long-term outcomes as well as their underlying mechanisms and suggested that propofol based total intravenous anesthesia and thoracic epidural analgesia could be preferred for HCC patients undergoing open liver resection rather than inhalational anesthesia.
References
More filters
Journal ArticleDOI
MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma.
Gang Shen,Xiaoxiang Rong,Jianbo Zhao,Xuewei Yang,Haibo Li,Hua Jiang,Qiang Zhou,Tianxing Ji,Sicong Huang,Jing Zhang,Hongyun Jia +10 more
TL;DR: The results suggest that miR-105 functions as a potential tumor suppressor by inhibiting the PI3K/AKT signaling pathway and might represent a potential therapeutic target for HCC patients.
Journal ArticleDOI
circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis
Yueyong Li,Yingjun Zhang,Shuai Zhang,Deyou Huang,Baosheng Li,Gencheng Liang,Yingning Wu,Qiulan Jiang,Longhua Li,Cheng Lin,Zhonghen Wei,Lingzhang Meng +11 more
TL;DR: It is demonstrated that circARNT2 modulates cisplatin resistance through miR-155-5p/PDK1 pathway and may serve as a promising therapeutic target for overcoming cisPlatin resistance for HCC.
Journal ArticleDOI
Propofol-induced miR-219-5p inhibits growth and invasion of hepatocellular carcinoma through suppression of GPC3-mediated Wnt/β-catenin signalling activation.
Ting Gong,Xue Ning,Zhiya Deng,Mingyu Liu,Beixian Zhou,Xijun Chen,Shisi Huang,Yan Xu,Zhongqing Chen,Rongcheng Luo +9 more
TL;DR: The results showed that treatment with propofol suppressed the proliferation, invasion and migration of HCC in vitro and demonstrated that prop ofol reversed the epithelial‐mesenchymal transition of Huh7 and SMMC7721 cells via miR‐219‐5p induction.
Journal ArticleDOI
Expression of NKG2D ligands is downregulated by β-catenin signalling and associates with HCC aggressiveness
Mathilde Cadoux,Stefano Caruso,Sandrine Pham,Angélique Gougelet,Céline Pophillat,Rozenn Riou,Robin Loesch,Sabine Colnot,Cong Trung Nguyen,Julien Calderaro,Séverine Celton-Morizur,Nadia Guerra,Jessica Zucman-Rossi,Chantal Desdouets,Jean-Pierre Couty +14 more
TL;DR: In this paper, the expression of NKG2D ligands in hepatocellular carcinoma (HCC) was evaluated in both humans and mice, taking the genomic features of HCC tumours into account.
Journal ArticleDOI
Propofol Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis Through Down-Regulating miR-374a in Hepatocarcinoma Cell Lines
TL;DR: Propofol inhibited cell proliferation, migration and invasion while promoted cell apoptosis of HepG2 and SMMC-7721 cells through inhibiting the Wnt/β-catenin and PI3K/ AKT pathways via down-regulation of miR-374a.
Related Papers (5)
MicroRNA‐26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin‐6‐Stat3 pathway
Xin Yang,Lei Liang,Lei Liang,Xiao-Fei Zhang,Xiao-Fei Zhang,Hu-Liang Jia,Hu-Liang Jia,Yi Qin,Yi Qin,Xu-Chao Zhu,Xu-Chao Zhu,Xiao-Mei Gao,Xiao-Mei Gao,Peng Qiao,Peng Qiao,Yan Zheng,Yan Zheng,Yuan-Yuan Sheng,Yuan-Yuan Sheng,Jinwang Wei,Jinwang Wei,Hai-Jun Zhou,Hai-Jun Zhou,Ning Ren,Ning Ren,Qing-Hai Ye,Qing-Hai Ye,Qiongzhu Dong,Qiongzhu Dong,Lun-Xiu Qin +29 more