Showing papers in "Cytokine in 2021"

TL;DR: The data suggest that TGF-β can be used as a predictive factor of disease severity in patients with COVID-19, and interferon-γ and IL-17 are involved in inducing and mediating proinflammatory responses.

TL;DR: Light is shed on role of IL-18 on COVID-19 pathogenesis and this study might provide an evidence for the clinical trials on IL- 18 antagonists for the treatment of severe CO VID-19 patients.

TL;DR: The ROC curve analysis showed that IL6 was the most accurate inflammatory biomarker and was positively correlated with other inflammatory markers and the kinetic analysis highlighted its value for monitoring COVID-19 patients.

TL;DR: The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in the Caucasian population, and the extent of the association was lower than the reported among Chinese, a population with a much higher frequency of the risk allele.

TL;DR: It is found that respiratory failure, acute kidney injury and 30-day mortality in critically ill Covid-19 patients are associated with moderate increases of a broad range of inflammatory mediators at time of admission.

TL;DR: In this article, an analysis of published data appertaining to the cytokine storms of COVID-19, H1N1 influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) reveals many common immunological and biochemical abnormalities.

TL;DR: Clinification of the pathogenic mechanisms of SARS-CoV-2 is needed to encourage prompt diagnosis and optimized care, and identifying the presence of cytokine storm in patients with neurological COVID-19 manifestations will facilitate avenues for treatment.

TL;DR: In this paper, the levels of various cytokines between pregnant women with confirmed coronavirus disease (COVID-19) infection and pregnant women without any defined risk factors were compared between the groups.

TL;DR: IL-6, M-CSF, sIL-2Rα, and HGF are possibly involved in the main biological processes of severe COVID-19, mirroring the level of systemic hyperinflammatory state, thelevel of lung inflammation, and the severity of organ damage.

TL;DR: The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial and destructive potentials as mentioned in this paper, which can exert opposing actions triggering either neuron survival after injury or causing neurodegeneration and cell death in neuropathic disorders.

TL;DR: In this paper, the authors evaluated the effect of HMGB1 inhibitor Glycyrrhizin on the cellular perturbations in lung cells expressing SARS-CoV-2 viral proteins.

TL;DR: It is revealed that the PBM could be helpful in reducing the lung inflammation and promoting the regeneration of the damaged tissue and infra-red lasers or light-emitting diodes (LEDs) are recommended in this regard.

TL;DR: In this article, a mouse model of psoriasis was established by topical imiquimod application on back skin and lncRNA MEG3 was cloned into the pcDNA3.1 vector and transfected in TNF-α-treated HaCaT and NHEK cells to overexpress its expression.

TL;DR: In patients with uremic pruritus the high levels of IL-31 indicates a possible role in pathogenesis, and IL-13 serum level on the other hand may be related to the severity of itch in these patients.

TL;DR: In this paper, the role of SNPs in the gene IFITM3 in SARS-CoV-2 infection and severity of COVID-19 was analyzed, and the effect of single nucleotide polymorphisms (SNPs) on the severity of the infection was investigated.

TL;DR: In this article, the authors evaluated the efficacy of netakimab in hospitalized patients with severe COVID-19 outside the intensive care unit (ICU) outside the ICU and found that the anti-IL-17 therapy might mitigate the inflammatory response and improve oxygenation but do not affect the need for mechanical ventilation and mortality.

TL;DR: Analysis of maximal and early concentrations of 12-plex cytokines in plasma found consistently elevated plasma levels of IL-6, IL-8 and IL-5 in patients who were deceased compared with those who had mild/moderate or severe disease, and correlation network analysis showed that IL- 6,IL-8, andIL-5 located at the center of an inter-correlated cytokine network.

TL;DR: In this article, the authors reviewed the current knowledge of COVID-19 associated cytokines, their roles in host immune and inflammatory responses, the clinical significance and utility of cytokine immunoassays in adult and pediatric COVID19 patients, as well as the challenges and pitfalls in implementation and interpretation of ILOASSays.

TL;DR: In this paper, a meta-analysis was conducted to systematically assess the changes in serum IL-6 in schizophrenia, which supports the immune regulatory system-compensatory immune regulatory systems hypothesis, and the role of inflammatory abnormalities in schizophrenia.

TL;DR: In this article, the authors evaluated a panel of biomarkers to phenotype patients and defined the role of immuno-inflammatory mediators as biomarkers of severity of severe acute respiratory syndrome caused by novel coronavirus 2 (SARS-CoV-2).

TL;DR: This review has reviewed these cytokines along with the organization, signaling, and functions through respective cytokine-receptor-families along with a temporal relationship between the cytokines and the progress of the infection towards the alternate outcomes- healing or non-healing- of the infections.

TL;DR: In this paper, the balance of Th17 and Treg cells, expression level of related master transcription factors, cytokines and microRNAs in mononuclear cells of peripheral blood of 30 patients with IMN and 30 healthy individuals before treatment was evaluated.

TL;DR: Results showed that blood glucose levels, diabetes incidence, body weight loss and insulitis in the pancreatic tissue were significantly reduced in mice treated with carvedilol, suggesting that carveilol is able to prevent pancreatic β-cell damage and the development of T1D in mice by the inhibition of inflammatory and oxidative mediators.

TL;DR: The platelet-rich plasma derivatives are orthobiologic tools of particular interest as mentioned in this paper, which can be obtained via centrifugation of a patient's whole blood and the components can then be subsequently isolated, concentrated and ultimately administered into injured tissues, particularly in areas where standard wound healing is disrupted.

TL;DR: In this article, the authors assess circulating levels of inflammatory cytokines in adult patients who were hospitalized with COVID-19 and stratified according to age (older or younger than 65 years) aiming to explore associations between these markers of inflammation and comorbidities.

TL;DR: In this article, the role of chemokines in the pathogenesis of systemic lupus erythematosus (SLE) and related complications was discussed. But, the role was not clarified in SLE patients or animal models.

TL;DR: Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation and maintaining tissue homeostasis, and studies have shown that TGF-α plays dual roles in cancer radiosensitivity and is involved in ionizing radiation-induced fibrosis in different tumor microenvironments as discussed by the authors.

TL;DR: Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation and mobilization of bone marrow neutrophils as mentioned in this paper.

TL;DR: In this article, a systematic review was performed using Medline and Web of Science covering the period of January 1996 to December 2019 according to the preferred reporting items for systematic reviews, which summarizes evidence for the use of salivary cytokines as biomarkers for oral and systemic diseases.

TL;DR: Cytokine deregulation, especially that of IL-6 and IL-17A, may be a powerful predictor of clinical prognosis for MM patients.