Journal ArticleDOI
Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions.
Lawrence J. Hirsch,Nicolas Gaspard,Andreas van Baalen,Rima Nabbout,Sophie Demeret,Tobias Loddenkemper,Vincent Navarro,Nicola Specchio,Lieven Lagae,Andrea O. Rossetti,Sara E. Hocker,Teneille Gofton,Nicholas S. Abend,Emily J. Gilmore,Cecil D. Hahn,Houman Khosravani,Houman Khosravani,Felix Rosenow,Eugen Trinka +18 more
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TLDR
An international group of experts were convened to standardize definitions of New‐Onset Refractory Status Epilepticus (NORSE), Febrile Infection‐Related Epilepsy Syndrome (FIRES), and related conditions to enable improved communication for investigators, physicians, families, patients, and other caregivers.Abstract:
We convened an international group of experts to standardize definitions of New-Onset Refractory Status Epilepticus (NORSE), Febrile Infection-Related Epilepsy Syndrome (FIRES), and related conditions. This was done to enable improved communication for investigators, physicians, families, patients, and other caregivers. Consensus definitions were achieved via email messages, phone calls, an in-person consensus conference, and collaborative manuscript preparation. Panel members were from 8 countries and included adult and pediatric experts in epilepsy, electroencephalography (EEG), and neurocritical care. The proposed consensus definitions are as follows: NORSE is a clinical presentation, not a specific diagnosis, in a patient without active epilepsy or other preexisting relevant neurological disorder, with new onset of refractory status epilepticus without a clear acute or active structural, toxic or metabolic cause. FIRES is a subcategory of NORSE, applicable for all ages, that requires a prior febrile infection starting between 2 weeks and 24 hours prior to onset of refractory status epilepticus, with or without fever at onset of status epilepticus. Proposed consensus definitions are also provided for Infantile Hemiconvulsion-Hemiplegia and Epilepsy syndrome (IHHE) and for prolonged, refractory and super-refractory status epilepticus. This document has been endorsed by the Critical Care EEG Monitoring Research Consortium. We hope these consensus definitions will promote improved communication, permit multicenter research, and ultimately improve understanding and treatment of these conditions.read more
Citations
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Anakinra Therapy for Non-cancer Inflammatory Diseases.
TL;DR: Anakinra has an unparalleled record of safety: opportunistic infections, particularly Mycobacterium tuberculosis, are rare even in populations at risk for reactivation of latent infections.
Journal ArticleDOI
New-onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectives
Nicolas Gaspard,Nicolas Gaspard,Lawrence J. Hirsch,Claudine Sculier,Claudine Sculier,Tobias Loddenkemper,Andreas van Baalen,Judette Lancrenon,Michel Emmery,Nicola Specchio,Raquel Farias-Moeller,Nora Wong,Rima Nabbout +12 more
TL;DR: The strategy to unravel the cause of these disorders and to improve patient care is presented and standardized consensus definitions and a multidisciplinary multicenter strategy are presented to improve clinical care for patients with NORSE and FIRES.
Journal ArticleDOI
International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology and Definitions
Nicola Specchio,Elaine C. Wirrell,Ingrid E. Scheffer,Rima Nabbout,Kate Riney,Pauline Samia,Marilisa M. Guerreiro,Sam Gwer,Sameer M. Zuberi,Jo M. Wilmshurst,Elissa G. Yozawitz,Ronit M. Pressler,E. C. Hirsch,Samuel Wiebe,JH Cross,Emilio Perucca,Solomon L. Moshé,Paolo Tinuper,Stéphane Auvin +18 more
TL;DR: The childhood onset epilepsy syndromes are described, most of which have both mandatory seizure type(s) and interictal electroencephalographic (EEG) features, highlighting the mandatory seizure(s), EEG features, phenotypic variations, and findings from key investigations.
Journal ArticleDOI
Tocilizumab treatment for new onset refractory status epilepticus.
TL;DR: Investigation of the therapeutic potential of the interleukin‐6 receptor inhibitor tocilizumab in patients with new onset refractory status epilepticus found no recurrence of SE, however, 2 patients experienced severe adverse events related to infection during the tocilIZumab therapy.
Journal ArticleDOI
Febrile seizures: an overview.
TL;DR: Continuous preventative antiepileptic therapy for the prevention of recurrent febrile seizures is not recommended and the use of intermittent anticonvulsant therapy is not routinely indicated.
References
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Journal ArticleDOI
ILAE Official Report: A practical clinical definition of epilepsy
Robert S. Fisher,Carlos Acevedo,Alexis Arzimanoglou,Alicia Bogacz,J. Helen Cross,Christian E. Elger,Jerome Engel,Lars Forsgren,Jacqueline A. French,Mike Glynn,Dale C. Hesdorffer,Byung In Lee,Gary W. Mathern,Solomon L. Moshé,Emilio Perucca,Ingrid E. Scheffer,Torbjörn Tomson,Masako Watanabe,Samuel Wiebe +18 more
TL;DR: A revised definition of epilepsy brings the term in concordance with common use for individuals who either had an age‐dependent epilepsy syndrome but are now past the applicable age or who have remained seizure‐free for the last 10 years and off antiseizure medicines for at least the last 5 years.
Journal ArticleDOI
A Definition and Classification of Status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus
Eugen Trinka,Hannah R. Cock,Dale C. Hesdorffer,Andrea O. Rossetti,Ingrid E. Scheffer,Shlomo Shinnar,Simon Shorvon,Daniel H. Lowenstein +7 more
TL;DR: A new diagnostic classification system of SE is proposed, which will provide a framework for clinical diagnosis, investigation, and therapeutic approaches for each patient, and it is proposed that this system should be divided into subcategories of known and unknown causes.
Journal ArticleDOI
Guidelines for the Evaluation and Management of Status Epilepticus
Gretchen M. Brophy,Rodney Bell,Jan Claassen,Brian K. Alldredge,Thomas P. Bleck,Tracy A. Glauser,Suzette M. LaRoche,James J. Riviello,Lori Shutter,Michael R. Sperling,David M. Treiman,Paul M. Vespa +11 more
TL;DR: Recommendations were developed based on the literature using standardized assessment methods from the American Heart Association and Grading of Recommendations Assessment, Development, and Evaluation systems, as well as expert opinion when sufficient data were lacking.
Journal ArticleDOI
New-onset refractory status epilepticus: Etiology, clinical features, and outcome
Nicolas Gaspard,Nicolas Gaspard,Brandon Foreman,Vincent Alvarez,Vincent Alvarez,Christian M. Cabrera Kang,John C. Probasco,Amy C. Jongeling,Emma Meyers,Alyssa R. Espinera,Kevin F. Haas,Sarah E. Schmitt,Elizabeth E. Gerard,Teneille Gofton,Peter W. Kaplan,Jong W. Lee,Benjamin Legros,Jerzy P. Szaflarski,Brandon Westover,Suzette M. LaRoche,Lawrence J. Hirsch +20 more
TL;DR: Autoimmune encephalitis is the most commonly identified cause of new-onset refractory status epilepticus, but half remain cryptogenic, and outcome at discharge is poor but improves during follow-up.
Journal ArticleDOI
Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES)
Rima Nabbout,Michel Mazzuca,Philippe Hubert,Sylviane Peudennier,Catherine Allaire,Vincent Flurin,Marina Aberastury,Walter Silva,Olivier Dulac +8 more
TL;DR: The effect of ketogenic diet (KD) in this condition of Fever induced refractory epileptic encephalopathy in school age children is reported.
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