Journal ArticleDOI
Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial
Christiane K. Kuhl,Stefanie Weigel,Simone Schrading,Birke Arand,Heribert Bieling,Roy König,Bernd Tombach,Claudia Leutner,Andrea Rieber-Brambs,Dennis Nordhoff,Walter Heindel,Maximilian F. Reiser,Hans H. Schild +12 more
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TLDR
In women at elevated familial risk, quality-assured MRI screening shifts the distribution of screen-detected breast cancers toward the preinvasive stage and neither mammography, nor annual or half-yearly ultrasound or CBE will add to the cancer yield achieved by MRI alone.Abstract:
Purpose We investigated the respective contribution (in terms of cancer yield and stage at diagnosis) of clinical breast examination (CBE), mammography, ultrasound, and quality-assured breast magnetic resonance imaging (MRI), used alone or in different combination, for screening women at elevated risk for breast cancer. Methods Prospective multicenter observational cohort study. Six hundred eighty-seven asymptomatic women at elevated familial risk (≥ 20% lifetime) underwent 1,679 annual screening rounds consisting of CBE, mammography, ultrasound, and MRI, read independently and in different combinations. In a subgroup of 371 women, additional half-yearly ultrasound and CBE was performed more than 869 screening rounds. Mean and median follow-up was 29.18 and 29.09 months. Results Twenty-seven women were diagnosed with breast cancer: 11 ductal carcinoma in situ (41%) and 16 invasive cancers (59%). Three (11%) of 27 were node positive. All cancers were detected during annual screening; no interval cancer occ...read more
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Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk
Wendie A. Berg,Zheng Zhang,Daniel Lehrer,Roberta A. Jong,Etta D. Pisano,Etta D. Pisano,Richard G. Barr,M. Böhm-Vélez,Mary C. Mahoney,W. Phil Evans,Linda Hovanessian Larsen,Marilyn J. Morton,Ellen B. Mendelson,Dione M. Farria,Jean B. Cormack,Helga S. Marques,Amanda M. Adams,Nolin M. Yeh,Glenna J. Gabrielli +18 more
TL;DR: The addition of screening ultrasound or MRI to mammography in women at increased risk of breast cancer resulted in not only a higher cancer detection yield but also an increase in false-positive findings.
Journal ArticleDOI
Abbreviated Breast Magnetic Resonance Imaging (MRI): First Postcontrast Subtracted Images and Maximum-Intensity Projection—A Novel Approach to Breast Cancer Screening With MRI
Christiane K. Kuhl,Simone Schrading,Kevin Strobel,Hans H. Schild,Ralf-Dieter Hilgers,Heribert Bieling +5 more
TL;DR: An MRI acquisitionTime of 3 minutes and an expert radiologist MIP image reading time of 3 seconds are sufficient to establish the absence of breast cancer, with an NPV of 99.8%.
Journal ArticleDOI
Breast MRI: EUSOBI recommendations for women's information.
Ritse M. Mann,Corinne Balleyguier,Pascal A. T. Baltzer,Ulrich Bick,Catherine Colin,Eleanor Cornford,Andrew Evans,Eva M. Fallenberg,Gabor Forrai,Michael Fuchsjäger,Fiona J. Gilbert,Thomas H. Helbich,Sylvia H. Heywang-Köbrunner,Julia Camps-Herrero,Christiane K. Kuhl,Laura Martincich,Federica Pediconi,Pietro Panizza,Luis Pina,Ruud M. Pijnappel,Katja Pinker-Domenig,Per Skaane,Francesco Sardanelli +22 more
TL;DR: Information on breast MRI concerns advantages/disadvantages and preparation to the examination, and Claustrophobia, implantable devices, allergic predisposition, and renal function should be checked.
Journal ArticleDOI
Multicenter Surveillance of Women at High Genetic Breast Cancer Risk Using Mammography, Ultrasonography, and Contrast-Enhanced Magnetic Resonance Imaging (the High Breast Cancer Risk Italian 1 Study): Final Results
Francesco Sardanelli,Franca Podo,Filippo Santoro,Siranoush Manoukian,Bergonzi S,Giovanna Trecate,Daniele Vergnaghi,Massimo Federico,Laura Cortesi,Stefano Corcione,Sandro Morassut,Cosimo Di Maggio,Anna Cilotti,Laura Martincich,Massimo Calabrese,Chiara Zuiani,Lorenzo Preda,Bernardo Bonanni,Luca Alessandro Carbonaro,A. Contegiacomo,Pietro Panizza,Ernesto Di Cesare,Antonella Savarese,Marcello Crecco,Daniela Turchetti,Maura Tonutti,Paolo Belli,Alessandro Del Maschio +27 more
TL;DR: MRI largely outperformed mammography, ultrasonography, and their combination for screening high-risk women below and over 50, including those with previous personal breast cancer.
Journal ArticleDOI
25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives
Jessica Lohrke,Thomas Frenzel,Jan Endrikat,Filipe Caseiro Alves,Thomas M. Grist,Meng Law,Jeong Min Lee,Tim Leiner,Kun Cheng Li,Konstantin Nikolaou,Martin R. Prince,Hans H. Schild,Jeffrey C. Weinreb,Kohki Yoshikawa,Hubertus Pietsch +14 more
TL;DR: An overview on the history of MRI and contrast media development is provided, to highlight certain key advances in the clinical development of CE-MRI, to outline current technical trends and clinical challenges, and to suggest some important future perspectives.
References
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Journal ArticleDOI
American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography
Debbie Saslow,Carla Boetes,Wylie Burke,Steven E. Harms,Martin O. Leach,Constance D. Lehman,Elizabeth A. Morris,Etta D. Pisano,Mitchell D. Schnall,Stephen F. Sener,Robert A. Smith,Ellen Warner,Martin J. Yaffe,Kimberly S. Andrews,Christy A. Russell +14 more
TL;DR: There are several risk subgroups for which the available data are insufficient to recommend for or against screening, including women with a personal history of breast cancer, carcinoma in situ, atypical hyperplasia, and extremely dense breasts on mammography.
Journal ArticleDOI
Efficacy of MRI and Mammography for Breast-Cancer Screening in Women with a Familial or Genetic Predisposition
Mieke Kriege,Cecile T. M. Brekelmans,Carla Boetes,Peter E. Besnard,H. M. Zonderland,Inge Marie Obdeijn,Radu A. Manoliu,Theo Kok,Hans Peterse,Madeleine M.A. Tilanus-Linthorst,Sara H. Muller,Sybren L. Meijer,Jan C. Oosterwijk,Louk V.A.M. Beex,Rob A. E. M. Tollenaar,Harry J. de Koning,Emiel J. Th. Rutgers,Jan G. M. Klijn +17 more
TL;DR: MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.
Journal Article
Efficacy of MRI and mammography for breast-cancer screening in women with familial or genetic predisposition
Mieke Kriege,C.T.M. Brekelmans,Carla Boetes,Steve Latosinsky,Geoffrey A. Porter,Todd M Tuttle +5 more
TL;DR: In this article, the authors compared mammography to MRI in detecting breast cancer in women with a familial or genetic predisposition to breast cancer, and found that MRI appears to be more sensitive than mammography.
Journal ArticleDOI
Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer.
Wendie A. Berg,Jeffrey D. Blume,Jean B. Cormack,Ellen B. Mendelson,Daniel Lehrer,M. Böhm-Vélez,Etta D. Pisano,Roberta A. Jong,W. Phil Evans,Marilyn J. Morton,Mary C. Mahoney,Linda Hovanessian Larsen,Richard G. Barr,Dione M. Farria,Helga S. Marques,Karan Boparai +15 more
TL;DR: The diagnostic yield, sensitivity, specificity, and diagnostic accuracy (assessed by the area under the receiver operating characteristic curve) of combined mammography plus ultrasound vs mammography alone and the positive predictive value of biopsy recommendations for mammographyplus ultrasound vs Mammography alone are compared.
Journal ArticleDOI
Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination.
Ellen Warner,Donald B. Plewes,Kimberley Hill,Petrina A. Causer,Judit Zubovits,Roberta A. Jong,Margaret R. Cutrara,Gerrit DeBoer,Martin J. Yaffe,Sandra J. Messner,Wendy S. Meschino,Cameron Piron,Steven A. Narod +12 more
TL;DR: In this article, the authors compared the sensitivity and specificity of four methods of breast cancer surveillance (mammography, ultrasound, MRI, and CBE) in women with hereditary susceptibility to breast cancer due to a BRCA1 or BRCa2 mutation.
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