Journal ArticleDOI
Protection from H1N1 influenza virus infections in mice by supplementation with selenium: a comparison with selenium-deficient mice.
TLDR
The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.Abstract:
The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-α and IFN-γ and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.read more
Citations
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Journal ArticleDOI
Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging
Joyce McCann,Bruce N. Ames +1 more
TL;DR: The same set of age‐related diseases and conditions are prospectively associated with modest Se deficiency and also with genetic dysfunction of nonessential selenoproteins, suggesting that Se deficiency could be a causal factor, a possibility strengthened by mechanistic evidence.
Journal ArticleDOI
Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies.
TL;DR: No in vivo or clinical studies were found that investigate the role of alkalization or earthing on respiratory viral infections, and future studies are recommended to reveal any potential curative effects.
Journal ArticleDOI
Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways.
TL;DR: In this article, surface decoration of selenium NPs by amantadine (Se@AM) was designed to reverse drug resistance caused by influenza virus infection, and the results demonstrate that Se@AM is a potentially efficient antiviral pharmaceutical agent for H1N1 influenza virus.
Journal ArticleDOI
Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19)
TL;DR: Selenium (Se) has been overlooked but may have a significant place in COVID-19 spectrum management, particularly in vulnerable elderly, and might represent a game changer in the global response to CO VID-19.
Journal ArticleDOI
Redox-Modulating Agents in the Treatment of Viral Infections.
Paola Checconi,Marta De Angelis,Maria Elena Marcocci,Alessandra Fraternale,Mauro Magnani,Anna Teresa Palamara,Anna Teresa Palamara,Lucia Nencioni +7 more
TL;DR: The effects of natural or synthetic redox-modulating molecules in inhibiting DNA or RNA virus replication as well as inflammatory pathways are described and could be usefully applied to fight other acute respiratory viral infections characterized by a strong inflammatory response, like COVID-19.
References
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Iconographies supplémentaires de l'article : Mechanisms of nutrient modulation of the immune response
TL;DR: In this paper, the development of tolerance, control of inflammation, and response to normal mucosal flora are interrelated and linked to specific immune mechanisms, and Leptin is emerging as a cytokine-like immune regulator that has complex effects in both overnutrition and in the inflammatory response in malnutrition.
Journal ArticleDOI
Mechanisms of nutrient modulation of the immune response.
TL;DR: In this paper, the development of tolerance, control of inflammation, and response to normal mucosal flora are interrelated and linked to specific immune mechanisms, and Leptin is emerging as a cytokine-like immune regulator that has complex effects in both overnutrition and in the inflammatory response in malnutrition.
Journal ArticleDOI
Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates.
TL;DR: To the best of the knowledge, this is the first report of a specific nutritional deficiency driving changes in a viral genome, permitting an avirulent virus to acquire virulence due to genetic mutation.
Journal ArticleDOI
Host nutritional selenium status as a driving force for influenza virus mutations.
George H. Brough,Songwei Wu,Donna L. Cioffi,Timothy Moore,Ming Li,Nicholas Dean,Troy Stevens +6 more
TL;DR: A role for endogenously expressed Trp1 in regulating a Ca2-selective current activated upon Ca2+ store depletion is supported.
Journal ArticleDOI
Host nutritional status: the neglected virulence factor.
TL;DR: It is shown that host nutritional status can influence not only the host response to the pathogen, but can also influence the genetic make-up of the viral genome.