Journal ArticleDOI
Protection from H1N1 influenza virus infections in mice by supplementation with selenium: a comparison with selenium-deficient mice.
TLDR
The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.Abstract:
The present paper describes protective effects of supplemental selenium in mice infected with influenza virus. The effects of supplemental selenium on serum selenium levels, mortality, lung virus titers, and cytokine titers were investigated in mice inoculated intranasally with suspensions of influenza virus. Whereas the mortality of the virus-infected Se-deficient mice was 75%, along with a marked reduction in body weight, lower levels of TNF-α and IFN-γ and lower serum selenium concentrations, the mortality of mice maintained on feed containing 0.5 mg Se/kg in the form of sodium selenite was 25%.There were no significantly differences, however, in viral titer between the Se-adequate and the selenium-supplemented groups. The data indicate that selenium supplementation may provide a feasible approach to improving the immune response to viral infections, such as lethal influenza infection.read more
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Selenium blocks porcine circovirus type 2 replication promotion induced by oxidative stress by improving GPx1 expression.
TL;DR: It is concluded that differences in morbidity and severity of PMWS observed on different pig farms may be related to variations in oxidative stress and that selenium has a potential role in the control of PCV2 infection.
Journal ArticleDOI
Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications
Samson Afewerki,Samson Afewerki,Nicole J. Bassous,Samarah V. Harb,Carlos Palo-Nieto,Guillermo U. Ruiz-Esparza,Guillermo U. Ruiz-Esparza,Fernanda Roberta Marciano,Thomas J. Webster,André Sales Aguiar Furtado,Anderson Oliveira Lobo,Anderson Oliveira Lobo +11 more
TL;DR: The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prothesis, all of these resulting in long-term rehabilitation, which is a huge burden to the public health system resulting in increased healthcare costs.
Journal ArticleDOI
Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism.
TL;DR: In this paper, the role of platelet activating factor (PAF) was suggested in the pathogenesis of COVID-19, and a healthy diet containing PAF inhibitors may target both inflammation and thrombosis and prevent the deleterious effects of the new coronavirus disease 2019 pandemic.
Journal ArticleDOI
The Advancing of Selenium Nanoparticles Against Infectious Diseases.
TL;DR: In this paper, the authors summarized the progress of preparation methods for Se NPs, followed by the advances of their biological functions and mechanisms for biomedical uses, especially in the field of anti-infection treatments.
Journal ArticleDOI
Advances in Research on the Toxicological Effects of Selenium
TL;DR: In this article, a systematic review of recent research on the toxicological effects of selenium is presented, aiming to provide theoretical references for SE-related research and theoretical support for the development of SE-containing drugs, SE-enriched dietary supplements, and SE-enhanced foods.
References
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Iconographies supplémentaires de l'article : Mechanisms of nutrient modulation of the immune response
TL;DR: In this paper, the development of tolerance, control of inflammation, and response to normal mucosal flora are interrelated and linked to specific immune mechanisms, and Leptin is emerging as a cytokine-like immune regulator that has complex effects in both overnutrition and in the inflammatory response in malnutrition.
Journal ArticleDOI
Mechanisms of nutrient modulation of the immune response.
TL;DR: In this paper, the development of tolerance, control of inflammation, and response to normal mucosal flora are interrelated and linked to specific immune mechanisms, and Leptin is emerging as a cytokine-like immune regulator that has complex effects in both overnutrition and in the inflammatory response in malnutrition.
Journal ArticleDOI
Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates.
TL;DR: To the best of the knowledge, this is the first report of a specific nutritional deficiency driving changes in a viral genome, permitting an avirulent virus to acquire virulence due to genetic mutation.
Journal ArticleDOI
Host nutritional selenium status as a driving force for influenza virus mutations.
George H. Brough,Songwei Wu,Donna L. Cioffi,Timothy Moore,Ming Li,Nicholas Dean,Troy Stevens +6 more
TL;DR: A role for endogenously expressed Trp1 in regulating a Ca2-selective current activated upon Ca2+ store depletion is supported.
Journal ArticleDOI
Host nutritional status: the neglected virulence factor.
TL;DR: It is shown that host nutritional status can influence not only the host response to the pathogen, but can also influence the genetic make-up of the viral genome.