Journal ArticleDOI
Protein changes in the human lens during development of sentile nuclear cataract
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TLDR
Senile nuclear cataractous lenses were divided into three groups of increasing nuclear color and a decrease of the amounts of the water-soluble and urea- soluble fractions and a concomitant increase of the Urea-insoluble fraction were observed in the nucleus as a function ofCataract development.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1976-05-20. It has received 54 citations till now.read more
Citations
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Diabetic cataract formation: potential role of glycosylation of lens crystallins.
TL;DR: A high glucose concentration in vivo or an increased glucose of glucose 6-phosphate concentration in vitro has been found to lead to the glycosylation of epsilon-amino groups of lysine residues in bovine and rat lens crystallins, suggesting a new interpretation of previous results on cataract formation and a new approach for development of drugs to prevent cataracts.
Journal ArticleDOI
Corticosteroid-induced cataracts
Robert C. Urban,Edward Cotlier +1 more
TL;DR: The association linking corticosteroid therapy with the development of posterior subcapsular cataracts has been well documented, and significant progress has been made in elucidating the mechanism by which corticoids bring about theDevelopment of these opacities.
Journal ArticleDOI
The state of sulphydryl groups in normal and cataractous human lenses
TL;DR: The level of protein-bound sulphydryl increases in the early stages of cataract formation but thereafter remains constant in both the cortex and nucleus, and there appear to be no intermolecular disulphide bonds in the Urea-soluble proteins of the lens but some may be present in the urea-insoluble proteins.
Journal ArticleDOI
Nonenzymatic addition of glucocorticoids to lens proteins in steroid-induced cataracts.
TL;DR: It is concluded that elevated glucocorticoid levels lead to the formation of glucoc Corticoid-lens protein adducts both in vitro and in vivo.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Colorimetric Method for Determination of Sugars and Related Substances
TL;DR: In this article, a method was developed to determine submicro amounts of sugars and related substances using a phenol-sulfuric acid reaction, which is useful for the determination of the composition of polysaccharides and their methyl derivatives.
Journal ArticleDOI
Phospholipids in tissues of the eye. I. Isolation, characterization and quantitative analysis by two-dimensional thin-layer chromatography of diacyl and vinyl-ether phospholipids.
TL;DR: Total phospholipid concentration in retina was relatively high, in vitreous body very low, and in iris, choroid, lens, cornea and sciera intermediate, and the concentrations of phosphatidyl glycerol, diphosphatidic acid, lysophosph atidyl choline and the unidentifiedospholipids were very low.
Journal ArticleDOI
α-Crystallin. The isolation and characterization of distinct macromolecular fractions
TL;DR: The concentration of macromolecules at the molecular-weight limits of a population are very low, and the members of the different populations do not appear to be in equilibrium with each other.
Related Papers (5)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
Structural proteins of the mammalian lens: a review with emphasis on changes in development, aging and cataract.
John J. Harding,Keith J. Dilley +1 more