Protein Sensors for Membrane Sterols
TLDR
Recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake are discussed.About:
This article is published in Cell.The article was published on 2006-01-13 and is currently open access. It has received 1502 citations till now. The article focuses on the topics: Sterol regulatory element-binding protein 2 & Sterol regulatory element-binding protein.read more
Citations
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Fundamentals of cancer metabolism
TL;DR: A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.
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Thyroid Hormone Regulation of Metabolism
TL;DR: The role of TH in regulating metabolic pathways has led to several new therapeutic targets for metabolic disorders and understanding the mechanisms and interactions of the various TH signaling pathways in metabolism will improve the likelihood of identifying effective and selective targets.
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Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
TL;DR: Persistent oxidative stress and protein misfolding initiate apoptotic cascades and are now known to play predominant roles in the pathogenesis of multiple human diseases including diabetes, atherosclerosis, and neurodegenerative diseases.
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Cellular cholesterol trafficking and compartmentalization
TL;DR: Increased understanding of these processes and their integration at the organ systems level provides fundamental insights into the physiology of cholesterol trafficking.
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The LDL Receptor
TL;DR: The history of the LDL receptor is recounted by its codiscoverers to explain a genetic cause of heart attacks and introduce three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors.
References
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Regulation of the mevalonate pathway.
TL;DR: The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control, and could be useful in treating certain forms of cancer as well as heart disease.
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
TL;DR: The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice and form the subject of this review.
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The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
Joyce J. Repa,Guosheng Liang,Jiafu Ou,Yuriy Bashmakov,Jean-Marc A. Lobaccaro,Iichiro Shimomura,Bei Shan,Michael S. Brown,Joseph L. Goldstein,David J. Mangelsdorf +9 more
TL;DR: A novel LXR target is described, the sterol regulatory element-binding protein-1c gene (SREBP-1C), which encodes a membrane-bound transcription factor of the basic helix-loop-helix-leucine zipper family and reveals a unique regulatory interplay between cholesterol and fatty acid metabolism.
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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
Jay D. Horton,Nila Shah,Janet A. Warrington,Norma N. Anderson,Sahng Wook Park,Michael S. Brown,Joseph L. Goldstein +6 more
TL;DR: Through application of stringent combinatorial criteria, the transgenic/knockout approach allows identification of genes whose activities are likely to be controlled directly by one family of transcription factors, in this case the SREBPs.