Provisional matrix: A role for versican and hyaluronan
Reads0
Chats0
TLDR
Targeting the hyaluronan and versican content of provisional matrices in a variety of diseases including, cardiovascular disease and cancer, is becoming an attractive strategy for intervention.About:
This article is published in Matrix Biology.The article was published on 2017-07-01 and is currently open access. It has received 158 citations till now. The article focuses on the topics: Versican & Tissue homeostasis.read more
Citations
More filters
Journal ArticleDOI
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication.
Pardis Pakshir,Boris Hinz +1 more
TL;DR: Understanding the mechanical and chemical state of the matrix and its effects on cellular processes will be essential to address diseases that are characterized by dysfunctional matrix, such as fibrosis.
Journal ArticleDOI
The extracellular matrix as a multitasking player in disease.
TL;DR: Critical and emerging issues related to matrix assembly in tissues and the multitasking roles for ECM in diseases such as osteoarthritis, fibrosis, cancer, and genetic diseases are presented.
Journal ArticleDOI
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics.
Nikos K. Karamanos,Nikos K. Karamanos,Zoi Piperigkou,Zoi Piperigkou,Achilleas D. Theocharis,Hideto Watanabe,Marco Franchi,Stéphanie Baud,Stéphane Brézillon,Martin Götte,Alberto Passi,Davide Vigetti,Sylvie Ricard-Blum,Ralph D. Sanderson,Thomas Neill,Renato V. Iozzo +15 more
TL;DR: The primary goal of this comprehensive review is to summarize major achievements and paradigm-shifting discoveries made on the PG/GAG chemistry-biology axis, focusing on structural variability, structure-function relationships, metabolic, molecular, and epigenetic mechanisms underlying their synthesis.
Journal ArticleDOI
TSG-6: A multifunctional protein with anti-inflammatory and tissue-protective properties.
TL;DR: This review focuses on the literature for TSG-6 over the last 10 years, summarizing its expression, structure, ligand-binding properties, biological functions and highlighting its potential as a therapeutic for a broad range of disease indications.
Journal ArticleDOI
Hyaluronan biology: A complex balancing act of structure, function, location and context.
TL;DR: This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.
References
More filters
Journal ArticleDOI
Cutaneous wound healing.
TL;DR: The primary goals of the treatment of wounds are rapid wound closure and a functional and aesthetically satisfactory scar.
Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
TL;DR: Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.
Journal ArticleDOI
Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
Journal ArticleDOI
Hyaluronan: from extracellular glue to pericellular cue
TL;DR: This work highlights a key role for interactions between hyaluronan and tumour cells in several aspects of malignancy and indicates the possibility of new therapeutic strategies.
Book
The Molecular and Cellular Biology of Wound Repair
Richard A.F. Clark,P. M. Henson +1 more
TL;DR: Wound Repair: Overview and General Considerations (R.A.F. Clark), Macrophage Involvement in Wound Repair, Remodeling and Fibrosis, and the Role of Plateletderived Growth Factor in vivo (C.W. Riches).
Related Papers (5)
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo,Liliana Schaefer +1 more