Pseudomonas genomes: diverse and adaptable
Mark W. Silby,Mark W. Silby,Craig Winstanley,Scott A. C. Godfrey,Stuart B. Levy,Robert W. Jackson +5 more
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Genome sequences of Pseudomonas spp.Abstract:
Members of the genus Pseudomonas inhabit a wide variety of environments, which is reflected in their versatile metabolic capacity and broad potential for adaptation to fluctuating environmental conditions. Here, we examine and compare the genomes of a range of Pseudomonas spp. encompassing plant, insect and human pathogens, and environmental saprophytes. In addition to a large number of allelic differences of common genes that confer regulatory and metabolic flexibility, genome analysis suggests that many other factors contribute to the diversity and adaptability of Pseudomonas spp. Horizontal gene transfer has impacted the capability of pathogenic Pseudomonas spp. in terms of disease severity (Pseudomonas aeruginosa) and specificity (Pseudomonas syringae). Genome rearrangements likely contribute to adaptation, and a considerable complement of unique genes undoubtedly contributes to strain- and species-specific activities by as yet unknown mechanisms. Because of the lack of conserved phenotypic differences, the classification of the genus has long been contentious. DNA hybridization and genome-based analyses show close relationships among members of P. aeruginosa, but that isolates within the Pseudomonas fluorescens and P. syringae species are less closely related and may constitute different species. Collectively, genome sequences of Pseudomonas spp. have provided insights into pathogenesis and the genetic basis for diversity and adaptation.read more
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Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia the official statement of the American Thoracic Society and the Infectious Disease Society of America (特集 救急診療ガイドライン) -- (海外のガイドライン)
TL;DR: The Methodology used to Prepare the Guideline Epidemiology Incidence Etiology and Recommendations for Assessing Response to Therapy Suggested Performance Indicators is summarized.
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The shared antibiotic resistome of soil bacteria and human pathogens
Kevin J. Forsberg,Alejandro Reyes,Bin Wang,Elizabeth M. Selleck,Morten Otto Alexander Sommer,Morten Otto Alexander Sommer,Gautam Dantas +6 more
TL;DR: Multidrug-resistant soil bacteria containing resistance cassettes against five classes of antibiotics are described that have perfect nucleotide identity to genes from diverse human pathogens, offering not only evidence of lateral exchange but also a mechanism by which antibiotic resistance disseminates.
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Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
TL;DR: An overview of the host response and how the genomic capacity of P. aeruginosa contributes to the pathogenesis and persistence of these infections is provided.
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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
TL;DR: The mechanism of antibiotic resistance in P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections.
Journal ArticleDOI
Genomics and taxonomy in diagnostics for food security: soft-rotting enterobacterial plant pathogens
TL;DR: Novel whole-genome classifications of the soft rot Enterobacteriaceae are presented, illustrating inconsistencies between the established taxonomies and evidence from completely sequenced isolates, and a perspective on the future impact of widespread whole- Genome sequencing and classification methods on detection and identification of bacterial plant pathogens in support of legislative and policy efforts in food security.
References
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
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Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
Martin C. J. Maiden,Jane A. Bygraves,Edward J. Feil,Giovanna Morelli,Joanne E. Russell,Rachel Urwin,Qing Zhang,Jiaji Zhou,Kerstin Zurth,Dominique A. Caugant,Ian M. Feavers,Mark Achtman,Brian G. Spratt +12 more
TL;DR: Multilocus sequence typing (MLST), which exploits the unambiguous nature and electronic portability of nucleotide sequence data for the characterization of microorganisms, can be applied to almost all bacterial species and other haploid organisms, including those that are difficult to cultivate.
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