Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
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TLDR
In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.Abstract:
Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics. Language: enread more
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Book ChapterDOI
Hallucinogens—psychedelics and dissociative drugs
TL;DR: Hallucinogens are compounds that when consumed, produce psychoactive physiological manifestations Physiological effects of hallucinogens include hallucinations, dissociative behavior, and aberrations in perception of the user's reality and their state of connectivity to tangible reality as mentioned in this paper.
Posted ContentDOI
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Flora Moujaes,Jie Lisa Ji,Masih Rahmati,Joshua B. Burt,Charles Schleifer,Brendan Adkinson,Aleksandar Savić,Nicole Santamauro,Zailyn Tamayo,Caroline Diehl,Antonija Kolobaric,Morgan Flynn,Nathalie M. Rieser,Clara Fonteneau,Terry Camarro,Junqian Xu,Youngsun T. Cho,Grega Repovs,Sarah K. Fineberg,Peter T. Morgan,Erich Seifritz,Franz X. Vollenweider,John H. Krystal,John D. Murray,Katrin H. Preller,Alan Anticevic +25 more
TL;DR: In this article , the authors quantified resting-state functional connectivity via data-driven global brain connectivity, related it to individual ketamine-induced symptom variation, and compared it to cortical gene expression targets.
Journal ArticleDOI
The crosstalk between 5-HT2AR and mGluR2 in schizophrenia
TL;DR: A review of the 5-HT2AR-mGluR2 heterocomplex and its potential implication in schizophrenia and antipsychotic drug action can be found in this article .
Journal ArticleDOI
Psychedelic drugs for psychiatric disorders
Sabrina Ângela Navarro Lima da Costa,Tyler S. Oesterle,Teresa A. Rummans,Elliott Richelson,Mark S. Gold +4 more
TL;DR: An overview of the evidence to date on psychedelic drugs for the treatment of psychiatric disorders can be found in this paper , where psilocybin, MDMA, and LSD have been evaluated in clinical trials.
Journal ArticleDOI
A unified model of ketamine’s dissociative and psychedelic properties
TL;DR: In this paper , the authors proposed that the fast, albeit transient, antidepressant effects observed after ketamine infusions are mainly driven by its acute modulation of reward circuits and sub-acute increase in neuroplasticity, while its dissociative and psychedelic properties are driven by dose and context-dependent disruption of large-scale functional networks.
References
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