Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
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TLDR
In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.Abstract:
Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics. Language: enread more
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HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Mitsumasa Kurita,Terrell Holloway,Aintzane García-Bea,Aintzane García-Bea,Alexey Kozlenkov,Allyson K. Friedman,José L. Moreno,Mitra Heshmati,Sam A. Golden,Pamela J. Kennedy,Nagahide Takahashi,David M. Dietz,Giuseppe Mocci,Ane M. Gabilondo,James B. Hanks,Adrienne Umali,Luis F. Callado,Amelia L. Gallitano,Rachael L. Neve,Li Shen,Joseph D. Buxbaum,Ming-Hu Han,Eric J. Nestler,J. Javier Meana,Scott J. Russo,Javier González-Maeso +25 more
TL;DR: It is found that chronic atypical antipsychotics downregulated the transcription of metabotropic glutamate 2 receptor (mGlu2), an effect that was associated with decreased histone acetylation at its promoter in mouse and human frontal cortex and support the view of HDAC2 as a promising new target for schizophrenia treatment.
Journal ArticleDOI
Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens.
TL;DR: The evidence demonstrating that the effects of indoleamine hallucinogens in a variety of animal behavioral paradigms are mediated by both 5-HT(2) and non-5-HT (2) receptors is reviewed.
Journal ArticleDOI
Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function.
TL;DR: An integrative review and novel insights regarding human research with classic psychedelics (classic hallucinogens), which are serotonin 2A receptor (5‐HT2AR) agonists such as lysergic acid diethylamide (LSD), mescaline, and psilocybin, are offered.
Journal ArticleDOI
Subjective effects and tolerability of the South American psychoactive beverage Ayahuasca in healthy volunteers
Jordi Riba,Antoni Rodríguez-Fornells,Gloria Urbano,Adelaida Morte,Rosa M. Antonijoan,Maria Montero,J. C. Callaway,Manel J. Barbanoj +7 more
TL;DR: Ayahuasca can be described as inducing changes in the perceptual, affective, cognitive, and somatic spheres, with a combination of stimulatory and visual psychoactive effects of longer duration and milder intensity than those previously reported for intravenously administered DMT.
Journal ArticleDOI
Mismatch negativity predicts psychotic experiences induced by nmda receptor antagonist in healthy volunteers
TL;DR: MMN generation appears to index the functional state of NMDAR-mediated neurotransmission even in subjects who do not demonstrate any psychopathology, which indicates a NMDar system that is more vulnerable to disruption by the N MDAR antagonist ketamine.
References
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