Journal ArticleDOI
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Franz X. Vollenweider,Margreet F. I. Vollenweider-Scherpenhuyzen,Andreas Bäbler,Helen Vogel,Daniel Hell +4 more
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TLDR
In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotics risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol.Abstract:
Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia. In healthy human volunteers, the psychotomimetic effects of psilocybin were blocked dose-dependently by the serotonin-2A antagonist ketanserin or the atypical antipsychotic risperidone, but were increased by the dopamine antagonist and typical antipsychotic haloperidol. These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. Thus, serotonin-2A overactivity may be involved in the pathophysiology of schizophrenia and serotonin-2A antagonism may contribute to therapeutic effects of antipsychotics. Language: enread more
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Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review
TL;DR: In this paper , a comprehensive overview of the current research on drug-drug interactions between classic psychedelics and other psychoactive drugs in humans is presented. But, the results reveal various effects when psychedelics are combined with other drugs, including both attenuated and potentiated effects and instances where no changes were observed.
Journal ArticleDOI
Hallucinations and Hallucinogens: Psychopathology or Wisdom?
José Carlos Bouso,Genís Ona,Maja Kohek,Rafael G. dos Santos,Jaime Eduardo Cecílio Hallak,Miguel Ángel Alcázar-Córcoles,Joan Obiols‐Llandrich +6 more
TL;DR: Hallucinations can offer a via regia to knowledge of the mind and the world as discussed by the authors , which could have several implications for fields such as drug policy, civil law and psychiatry, as well as for the stigma associated with mental disorders.
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G protein coupled receptors as targets for transformative neuropsychiatric therapeutics.
Gavin P. Schmitz,Bryan L. Roth +1 more
TL;DR: In this paper , the authors consider whether there might be new opportunities for transformative therapeutics for neuropsychiatric disorders by specifically targeting both known and understudied GPCRs, and they show how recent insights into the structure, function, signaling, and cell biology of these receptors has led to potentially novel therapeutics.
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Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action?
TL;DR: A review of the putative neurobiological underpinnings of the mechanism of antidepressant action of serotonergic psychedelics was conducted in this article , where a narrative review was conducted using PubMed to identify published articles evaluating the antidepressant mechanism of action.
References
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Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
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Journal ArticleDOI
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Journal ArticleDOI
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Daniel Hoyer,Philippe Schoeffter +1 more
TL;DR: Three main families of 5-HT receptors, of which subtypes have been described, are now accepted, and heterogeneity is further substantiated by the cloning of the cDNA's of three different 5- HT receptors.